Detailed Information on Publication Record
2023
Paulownia tomentosa fruit extracts activity in eradication of Staphylococcus aureus
ŠKOVRANOVÁ, Gabriela, Lenka MOLČANOVÁ, Anja KLANČNIK, Blaž JUG, Sonja SMOLE-MOŽINA et. al.Basic information
Original name
Paulownia tomentosa fruit extracts activity in eradication of Staphylococcus aureus
Authors
ŠKOVRANOVÁ, Gabriela (703 Slovakia, guarantor, belonging to the institution), Lenka MOLČANOVÁ (703 Slovakia, belonging to the institution), Anja KLANČNIK (705 Slovenia), Blaž JUG (705 Slovenia), Sonja SMOLE-MOŽINA (705 Slovenia) and Alice SYCHROVÁ (203 Czech Republic, belonging to the institution)
Edition
PSE Young Scientists’ Meeting 28th – 30th June 2023, Paris, France, 2023
Other information
Language
English
Type of outcome
Prezentace na konferencích
Field of Study
10608 Biochemistry and molecular biology
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
RIV identification code
RIV/00216224:14160/23:00132828
Organization unit
Faculty of Pharmacy
Keywords (in Czech)
antimikrobiální aktivity; Paulownia tomentosa; inhibice quorum-sensing; Staphylococcus aureus; hojení ran
Keywords in English
antibacterial activity; Paulownia tomentosa; quorum-sensing inhibition; Staphylococcus aureus; wound healing
Změněno: 15/1/2024 13:42, PharmDr. Gabriela Škovranová, Ph.D.
Abstract
V originále
Staphylococcus aureus has a broad virulence capacity and biofilm formation limits the control of wound infections. Paulownia tomentosa Steud. (Paulowniaceae) is a rich source of geranylated phenolics responsible for various bioactivities. Ethanolic extract, chloroform fraction, and three flavonoids showed significant antimicrobial activity. In combination with fusidic acid and mupirocin, synergistic potential was observed. Membrane disruption is partly responsible for the antimicrobial activity of geranylated flavonoids. Selected plant formulations reduced the adhesion of bacteria to the abiotic surface, and also the inhibition of intercellular communication and quorum-sensing was described.
Links
| MUNI/A/1212/2022, interní kód MU |
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