a 2023

A web-based bioinformatic tool LYNX for targeted LYmphoid NeXt- generation sequencing data analysis and visualization for hematooncology.

REIGL, Tomáš, Jakub Paweł PORC, Veronika NAVRKALOVÁ, Jakub HYNŠT, Karol PÁL et. al.

Basic information

Original name

A web-based bioinformatic tool LYNX for targeted LYmphoid NeXt- generation sequencing data analysis and visualization for hematooncology.

Authors

REIGL, Tomáš (203 Czech Republic, belonging to the institution), Jakub Paweł PORC (616 Poland, belonging to the institution), Veronika NAVRKALOVÁ (203 Czech Republic, belonging to the institution), Jakub HYNŠT (203 Czech Republic, belonging to the institution), Karol PÁL (703 Slovakia, belonging to the institution), Kamila STRÁNSKÁ (203 Czech Republic, belonging to the institution), Jana KOTAŠKOVÁ (203 Czech Republic, belonging to the institution), Šárka POSPÍŠILOVÁ (203 Czech Republic, guarantor, belonging to the institution) and Karla PLEVOVÁ (203 Czech Republic, belonging to the institution)

Edition

ESHG Conference 2023, Glasgow, Skotsko, 2023

Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

10201 Computer sciences, information science, bioinformatics

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

RIV identification code

RIV/00216224:14740/23:00132843

Organization unit

Central European Institute of Technology

Keywords in English

Next-generation sequencing; genetic markers; lymphoid malignancies; LYNX

Tags

Tags

International impact, Reviewed
Změněno: 24/3/2024 12:09, Mgr. Eva Dubská

Abstract

V originále

Next-generation sequencing (NGS) is one of the most rapidly expanding technologies in laboratory medicine. In routine diagnostics, a single NGS experiment can replace several laboratory tests and provide more information about the disease being tested. Commonly, the assistance of a qualified bioinformatician or a dedicated tool is necessary for the data analysis. Our team has created an integrative, targeted NGS panel that detects genetic markers common for most abundant lymphoid malignancies (PMID: 34082072). For this panel, we have developed a bioinformatic tool, LYNX, with a user interface (UI) that allows diagnosticians to easily analyze the data and interactively visualize the results. This facilitates data interpretation and speeds up diagnostic procedures.

Links

LM2018140, research and development project
Name: e-Infrastruktura CZ (Acronym: e-INFRA CZ)
Investor: Ministry of Education, Youth and Sports of the CR
LX22NPO5102, research and development project
Name: Národní ústav pro výzkum rakoviny (Acronym: NÚVR)
Investor: Ministry of Education, Youth and Sports of the CR, National institute for cancer research, 5.1 EXCELES
NU20-08-00314, research and development project
Name: Single cell analýza: moderní nástroj pro studium klonální evoluce u pacientů s chronickou lymfocytární leukémií s vysokým rizikem (Acronym: Single cell analysis of CLL cells)
Investor: Ministry of Health of the CR, Subprogram 1 - standard
NU21-08-00237, research and development project
Name: Pokročilé sekvenační metody pro analýzu strukturních přestaveb nádorového genomu
Investor: Ministry of Health of the CR, Advanced sequencing methods for deciphering structural variants in cancer genome, Subprogram 1 - standard
NU22-08-00227, research and development project
Name: Pokročilé molekulární analýzy pro komplexní diagnostiku a monitorování pacientů s difúzním velkobuněčným B-lymfomem: využití profilování genové exprese, tekutých biopsií a sekvenování třetí generace
Investor: Ministry of Health of the CR, Advanced molecular testing for aggregate diagnosis and management of DLBCL patients: engagement of gene expression profiling, liquid biopsy and long-read sequencing, Subprogram 1 - standard