| KUSOVÁ, Alžbeta, Lenka STEINBACHOVÁ, Tereza PŘEROVSKÁ, Lenka ZÁVESKÁ DRÁBKOVÁ, Jan PALEČEK, Ahamed KHAN, Gabriela RIGÓOVÁ, Zuzana GADIOU, Claire JOURDAIN, Tino STRICKER, Daniel SCHUBERT, David HONYS and Petra PROCHÁZKOVÁ SCHRUMPFOVÁ. Completing the TRB family: newly characterized members show ancient evolutionary origins and distinct localization, yet similar interactions. Plant Molecular Biology. Springer, 2023, vol. 112, 1-2, p. 61-83. ISSN 0167-4412. Available from: https://dx.doi.org/10.1007/s11103-023-01348-2. |
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@article{2358472,
author = {Kusová, Alžbeta and Steinbachová, Lenka and Přerovská, Tereza and Záveská Drábková, Lenka and Paleček, Jan and Khan, Ahamed and Rigóová, Gabriela and Gadiou, Zuzana and Jourdain, Claire and Stricker, Tino and Schubert, Daniel and Honys, David and Procházková Schrumpfová, Petra},
article_number = {1-2},
doi = {http://dx.doi.org/10.1007/s11103-023-01348-2},
keywords = {Telomere repeat binding; TRB; PRC2; PEAT; TERT; Telomeric},
language = {eng},
issn = {0167-4412},
journal = {Plant Molecular Biology},
title = {Completing the TRB family: newly characterized members show ancient evolutionary origins and distinct localization, yet similar interactions},
url = {https://doi.org/10.1007/s11103-023-01348-2},
volume = {112},
year = {2023}
}
TY - JOUR
ID - 2358472
AU - Kusová, Alžbeta - Steinbachová, Lenka - Přerovská, Tereza - Záveská Drábková, Lenka - Paleček, Jan - Khan, Ahamed - Rigóová, Gabriela - Gadiou, Zuzana - Jourdain, Claire - Stricker, Tino - Schubert, Daniel - Honys, David - Procházková Schrumpfová, Petra
PY - 2023
TI - Completing the TRB family: newly characterized members show ancient evolutionary origins and distinct localization, yet similar interactions
JF - Plant Molecular Biology
VL - 112
IS - 1-2
SP - 61-83
EP - 61-83
PB - Springer
SN - 01674412
KW - Telomere repeat binding
KW - TRB
KW - PRC2
KW - PEAT
KW - TERT
KW - Telomeric
UR - https://doi.org/10.1007/s11103-023-01348-2
N2 - Telomere repeat binding proteins (TRBs) belong to a family of proteins possessing a Myb-like domain which binds to telomeric repeats. Three members of this family (TRB1, TRB2, TRB3) from Arabidopsis thaliana have already been described as associated with terminal telomeric repeats (telomeres) or short interstitial telomeric repeats in gene promoters (telo-boxes). They are also known to interact with several protein complexes: telomerase, Polycomb repressive complex 2 (PRC2) E(z) subunits and the PEAT complex (PWOs-EPCRs-ARIDs-TRBs). Here we characterize two novel members of the TRB family (TRB4 and TRB5). Our wide phylogenetic analyses have shown that TRB proteins evolved in the plant kingdom after the transition to a terrestrial habitat in Streptophyta, and consequently TRBs diversified in seed plants. TRB4-5 share common TRB motifs while differing in several others and seem to have an earlier phylogenetic origin than TRB1-3. Their common Myb-like domains bind long arrays of telomeric repeats in vitro, and we have determined the minimal recognition motif of all TRBs as one telo-box. Our data indicate that despite the distinct localization patterns of TRB1-3 and TRB4-5 in situ, all members of TRB family mutually interact and also bind to telomerase/PRC2/PEAT complexes. Additionally, we have detected novel interactions between TRB4-5 and EMF2 and VRN2, which are Su(z)12 subunits of PRC2.
ER -
KUSOVÁ, Alžbeta, Lenka STEINBACHOVÁ, Tereza PŘEROVSKÁ, Lenka ZÁVESKÁ DRÁBKOVÁ, Jan PALEČEK, Ahamed KHAN, Gabriela RIGÓOVÁ, Zuzana GADIOU, Claire JOURDAIN, Tino STRICKER, Daniel SCHUBERT, David HONYS and Petra PROCHÁZKOVÁ SCHRUMPFOVÁ. Completing the TRB family: newly characterized members show ancient evolutionary origins and distinct localization, yet similar interactions. \textit{Plant Molecular Biology}. Springer, 2023, vol.~112, 1-2, p.~61-83. ISSN~0167-4412. Available from: https://dx.doi.org/10.1007/s11103-023-01348-2.
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