Safety and Outcome of Revascularization Treatment in Patients With Acute Ischemic Stroke and COVID-19 The Global COVID-19 Stroke Registry
Authors
MARTO, Joao Pedro (guarantor), Davide N STRAMBO, George NTAIOS, Thanh NGUYEN, Roman HERZIG, Anna CZLONKOWSKA, Jelle DEMEESTERE, Ossama Yassin MANSOUR, Alexander SALERNO, Susanne W WEGENER, Philipp BAUMGARTNER, Carlo CEREDA, Giovanni BIANCO, Morin BEYELER, Marcel ARNOLD, Emmanuel CARRERA, Paolo MACHI, Valerian ALTERSBERGER, Leo BONATI, Henrik GENSICKE, Manuel BOLOGNESE, Nils PETERS, Stephan WETZEL, Marta MAGRICO, Joao Nuno RAMOS, Joao SARGENTO-FREITAS, Rita MACHADO, Carolina MAIA, Egidio MACHADO, Ana Paiva NUNES, Patricia FERREIRA, Pinho e Melo TERESA, Mariana Carvalho DIAS, Andre PAULA, Manuel Alberto CORREIA, Pedro CASTRO, Elsa AZEVEDO, Luis ALBUQUERQUE, Jose Nuno ALVES, Joana FERREIRA-PINTO, Torcato MEIRA, Liliana PEREIRA, Miguel RODRIGUES, Andre Pinho ARAUJO, Marta RODRIGUES, Mariana ROCHA, Angelo PEREIRA-FONSECA, Luis RIBEIRO, Ricardo VARELA, Sofia MALHEIRO, Manuel CAPPELLARI, Cecilia ZIVELONGHI, Giulia SAJEVA, Andrea ZINI, Mauro GENTILE, Stefano FORLIVESI, Ludovica MIGLIACCIO, Maria SESSA, La Gioia SARA, Alessandro PEZZINI, Davide SANGALLI, Marialuisa ZEDDE, Rosario PASCARELLA, Carlo FERRARESE, Simone BERETTA, Susanna DIAMANTI, Ghil SCHWARZ, Giovanni FRISULLO, Simona MARCHESELLI, Pierre SENERS, Candice SABBEN, Simon ESCALARD, Michel PIOTIN, Benjamin MAIER, Guillaume CHARBONNIER, Fabrice VUILLIER, Loic R LEGRIS, Pauline CUISENIER, Francesca VODRET, Gaultier MARNAT, Jean-Sebastien LIEGEY, Igor SIBON, Fabian FLOTTMANN, Gabriel O BROOCKS, Nils-Ole GLOYER, Ferdinand BOHMANN, Jan Hendrik J SCHAEFER, Christian NOLTE, Heinrich AUDEBERT, Eberhard SIEBERT, Marek SYKORA, Wilfried LANG, Julia FERRARI, Lukas MAYER-SUESS, Michael KNOFLACH, Elke Ruth J GIZEWSKI, Jeffrey M STOLP, Lotte STOLZE, Jonathan COUTINHO, Paul NEDERKOORN, van den Wijngaard IDO, De Meris JOKE, Robin LEMMENS, De Raedt SYLVIE, Fenne VANDERVORST, Matthieu Pierre RUTGERS, Antoine GUILMOT, Anne DUSART, Flavio BELLANTE, Patricia CALLEJA-CASTANO, Fernando OSTOS, Guillermo GONZALEZ-ORTEGA, Paloma MARTIN-JIMENEZ, Sebastian GARCIA-MADRONA, Antonio CRUZ-CULEBRAS, Rocio VERA, Maria Consuelo MATUTE, Blanca FUENTES, Maria ALONSO-DE-LECINANA, Ricardo RIGUAL, Exuperio DIEZ-TEJEDOR, Soledad PEREZ-SANCHEZ, Joan MONTANER, Fernando DIAZ-OTERO, Natalia PEREZ-DE-LA-OSSA, Belen FLORES-PINA, Lucia MUNOZ-NARBONA, Angel CHAMORRO, Alejandro RODRIGUEZ-VAZQUEZ, Arturo RENU, Oscar AYO-MARTIN, Francisco HERNANDEZ-FERNANDEZ, Tomas SEGURA, Herbert TEJADA-MEZA, Daniel SAGARRA-MUR, Marta SERRANO-PONZ, Thant HLAING, Isaiah SEE, Robert SIMISTER, David WERRING, Espen Saxhaug KRISTOFFERSEN, Annika NORDANSTIG, Katarina JOOD, Alexandros RENTZOS, Libor SIMUNEK, Dagmar KRAJICKOVA, Antonín KRAJINA, Robert MIKULÍK (203 Czech Republic, belonging to the institution), Martina CVIKOVÁ (703 Slovakia, belonging to the institution), Jan VINKLÁREK (203 Czech Republic, belonging to the institution), David SKOLOUDIK, Martin ROUBEC, Eva HURTIKOVA, Rostislav HRUBY, Svatopluk OSTRY, Ondrej SKODA, Marek PERNICKA, Lubomir JURAK, Zuzana EICHLOVA, Martin JIRA, Martin KOVAR, Michal PANSKY, Pavel MENCL, Hana PALOUSKOVA, Ales TOMEK, Petr JANSKY, Anna OLSEROVA, Martin SRAMEK, Roman HAVLICEK, Petr MALY, Lukas TRAKAL, Jan FIKSA, Matej SLOVAK, Michal Adam KARLINSKI, Maciej NOWAK, Halina SIENKIEWICZ-JAROSZ, Anna BOCHYNSKA, Pawel WRONA, Tomasz HOMA, Katarzyna SAWCZYNSKA, Agnieszka SLOWIK, Ewa WLODARCZYK, Marcin WIACEK, Izabella TOMASZEWSKA-LAMPART, Bartosz SIECZKOWSKI, Halina BARTOSIK-PSUJEK, Marta BILIK, Anna BANDZAREWICZ, Malgorzata DOROBEK, Justyna ZIELINSKA-TUREK, Marta NOWAKOWSKA-KOTAS, Krystian OBARA, Pawel URBANOWSKI, Slawomir BUDREWICZ, Maciej GUZINSKI, Milena SWITONSKA, Iwona RUTKOWSKA, Paulina M SOBIESZAK-SKURA, Beata LABUZ-ROSZAK, Aleksander DEBIEC, Jacek STASZEWSKI, Adam STEPIEN, Jacek ZWIERNIK, Grzegorz WASILEWSKI, Cristina TIU, Elena Oana TERECOASA, Razvan Alexandru RADU, Anca NEGRILA, Bogdan DOROBAT, Cristina PANEA, Vlad TIU, Simona PETRESCU, Atilla OZDEMIR, Mostafa MAHMOUD, Hussam EL-SAMAHY, Hazem ABDELKHALEK, Jasem AL-HASHEL, Ismail Ibrahim ISMAIL, Athari SALMEEN, Abdoreza GHOREISHI, Sergiu Ionut SABETAY, Hana GROSS, Piers KLEIN, Mohamad ABDALKADER, Pascal JABBOUR, El Naamani KAREEM, Stavropoula TJOUMAKARIS, Rawad A ABBAS, Ghada MOHAMED, Alex CHEBL, Jiangyong MIN, Majesta P HOVINGH, Jenney TSAI, Muhib KHAN, Krishna NALLEBALLE, Sanjeeva ONTEDDU, Hesham MASOUD, Michael MINA, Navreet KAUR, Laith G MAALI, Michael ABRAHAM, Priyank KHANDELWAL, Ivo BACH, Melody ONG, Denis M BABICI, Ayaz KHAWAJA, Maryam HAKEMI, Kumar RAJAMANI, Vanessa CANO-NIGENDA, Antonio ARAUZ, Pablo AMAYA, Natalia LLANOS, Akemi ARANGO, Miguel Angel VENCES, Barrientos Guerra Jose DOMINGUO, Rayllene CAETANO, Rodrigo Targa MARTINS, Sergio Daniel SCOLLO, Patrick Matic YALUNG, Shashank NAGENDRA, Abhijit GAIKWAD, Kwon-Duk SEO, Georgios G GEORGIOPOULOS, Raul NOGUEIRA and Patrik MICHEL
Edition
Neurology, Philadelphia, LIPPINCOTT WILLIAMS & WILKINS, 2023, 0028-3878
Background and ObjectivesCOVID-19-related inflammation, endothelial dysfunction, and coagulopathy may increase the bleeding risk and lower the efficacy of revascularization treatments in patients with acute ischemic stroke (AIS). We aimed to evaluate the safety and outcomes of revascularization treatments in patients with AIS and COVID-19.MethodsThis was a retrospective multicenter cohort study of consecutive patients with AIS receiving intravenous thrombolysis (IVT) and/or endovascular treatment (EVT) between March 2020 and June 2021 tested for severe acute respiratory syndrome coronavirus 2 infection. With a doubly robust model combining propensity score weighting and multivariate regression, we studied the association of COVID-19 with intracranial bleeding complications and clinical outcomes. Subgroup analyses were performed according to treatment groups (IVT-only and EVT).ResultsOf a total of 15,128 included patients from 105 centers, 853 (5.6%) were diagnosed with COVID-19; of those, 5,848 (38.7%) patients received IVT-only and 9,280 (61.3%) EVT (with or without IVT). Patients with COVID-19 had a higher rate of symptomatic intracerebral hemorrhage (SICH) (adjusted OR 1.53; 95% CI 1.16-2.01), symptomatic subarachnoid hemorrhage (SSAH) (OR 1.80; 95% CI 1.20-2.69), SICH and/or SSAH combined (OR 1.56; 95% CI 1.23-1.99), 24-hour mortality (OR 2.47; 95% CI 1.58-3.86), and 3-month mortality (OR 1.88; 95% CI 1.52-2.33). Patients with COVID-19 also had an unfavorable shift in the distribution of the modified Rankin score at 3 months (OR 1.42; 95% CI 1.26-1.60).DiscussionPatients with AIS and COVID-19 showed higher rates of intracranial bleeding complications and worse clinical outcomes after revascularization treatments than contemporaneous non-COVID-19 patients receiving treatment. Current available data do not allow direct conclusions to be drawn on the effectiveness of revascularization treatments in patients with COVID-19 or to establish different treatment recommendations in this subgroup of patients with ischemic stroke. Our findings can be taken into consideration for treatment decisions, patient monitoring, and establishing prognosis.
MARTO, Joao Pedro, Davide N STRAMBO, George NTAIOS, Thanh NGUYEN, Roman HERZIG, Anna CZLONKOWSKA, Jelle DEMEESTERE, Ossama Yassin MANSOUR, Alexander SALERNO, Susanne W WEGENER, Philipp BAUMGARTNER, Carlo CEREDA, Giovanni BIANCO, Morin BEYELER, Marcel ARNOLD, Emmanuel CARRERA, Paolo MACHI, Valerian ALTERSBERGER, Leo BONATI, Henrik GENSICKE, Manuel BOLOGNESE, Nils PETERS, Stephan WETZEL, Marta MAGRICO, Joao Nuno RAMOS, Joao SARGENTO-FREITAS, Rita MACHADO, Carolina MAIA, Egidio MACHADO, Ana Paiva NUNES, Patricia FERREIRA, Pinho e Melo TERESA, Mariana Carvalho DIAS, Andre PAULA, Manuel Alberto CORREIA, Pedro CASTRO, Elsa AZEVEDO, Luis ALBUQUERQUE, Jose Nuno ALVES, Joana FERREIRA-PINTO, Torcato MEIRA, Liliana PEREIRA, Miguel RODRIGUES, Andre Pinho ARAUJO, Marta RODRIGUES, Mariana ROCHA, Angelo PEREIRA-FONSECA, Luis RIBEIRO, Ricardo VARELA, Sofia MALHEIRO, Manuel CAPPELLARI, Cecilia ZIVELONGHI, Giulia SAJEVA, Andrea ZINI, Mauro GENTILE, Stefano FORLIVESI, Ludovica MIGLIACCIO, Maria SESSA, La Gioia SARA, Alessandro PEZZINI, Davide SANGALLI, Marialuisa ZEDDE, Rosario PASCARELLA, Carlo FERRARESE, Simone BERETTA, Susanna DIAMANTI, Ghil SCHWARZ, Giovanni FRISULLO, Simona MARCHESELLI, Pierre SENERS, Candice SABBEN, Simon ESCALARD, Michel PIOTIN, Benjamin MAIER, Guillaume CHARBONNIER, Fabrice VUILLIER, Loic R LEGRIS, Pauline CUISENIER, Francesca VODRET, Gaultier MARNAT, Jean-Sebastien LIEGEY, Igor SIBON, Fabian FLOTTMANN, Gabriel O BROOCKS, Nils-Ole GLOYER, Ferdinand BOHMANN, Jan Hendrik J SCHAEFER, Christian NOLTE, Heinrich AUDEBERT, Eberhard SIEBERT, Marek SYKORA, Wilfried LANG, Julia FERRARI, Lukas MAYER-SUESS, Michael KNOFLACH, Elke Ruth J GIZEWSKI, Jeffrey M STOLP, Lotte STOLZE, Jonathan COUTINHO, Paul NEDERKOORN, van den Wijngaard IDO, De Meris JOKE, Robin LEMMENS, De Raedt SYLVIE, Fenne VANDERVORST, Matthieu Pierre RUTGERS, Antoine GUILMOT, Anne DUSART, Flavio BELLANTE, Patricia CALLEJA-CASTANO, Fernando OSTOS, Guillermo GONZALEZ-ORTEGA, Paloma MARTIN-JIMENEZ, Sebastian GARCIA-MADRONA, Antonio CRUZ-CULEBRAS, Rocio VERA, Maria Consuelo MATUTE, Blanca FUENTES, Maria ALONSO-DE-LECINANA, Ricardo RIGUAL, Exuperio DIEZ-TEJEDOR, Soledad PEREZ-SANCHEZ, Joan MONTANER, Fernando DIAZ-OTERO, Natalia PEREZ-DE-LA-OSSA, Belen FLORES-PINA, Lucia MUNOZ-NARBONA, Angel CHAMORRO, Alejandro RODRIGUEZ-VAZQUEZ, Arturo RENU, Oscar AYO-MARTIN, Francisco HERNANDEZ-FERNANDEZ, Tomas SEGURA, Herbert TEJADA-MEZA, Daniel SAGARRA-MUR, Marta SERRANO-PONZ, Thant HLAING, Isaiah SEE, Robert SIMISTER, David WERRING, Espen Saxhaug KRISTOFFERSEN, Annika NORDANSTIG, Katarina JOOD, Alexandros RENTZOS, Libor SIMUNEK, Dagmar KRAJICKOVA, Antonín KRAJINA, Robert MIKULÍK, Martina CVIKOVÁ, Jan VINKLÁREK, David SKOLOUDIK, Martin ROUBEC, Eva HURTIKOVA, Rostislav HRUBY, Svatopluk OSTRY, Ondrej SKODA, Marek PERNICKA, Lubomir JURAK, Zuzana EICHLOVA, Martin JIRA, Martin KOVAR, Michal PANSKY, Pavel MENCL, Hana PALOUSKOVA, Ales TOMEK, Petr JANSKY, Anna OLSEROVA, Martin SRAMEK, Roman HAVLICEK, Petr MALY, Lukas TRAKAL, Jan FIKSA, Matej SLOVAK, Michal Adam KARLINSKI, Maciej NOWAK, Halina SIENKIEWICZ-JAROSZ, Anna BOCHYNSKA, Pawel WRONA, Tomasz HOMA, Katarzyna SAWCZYNSKA, Agnieszka SLOWIK, Ewa WLODARCZYK, Marcin WIACEK, Izabella TOMASZEWSKA-LAMPART, Bartosz SIECZKOWSKI, Halina BARTOSIK-PSUJEK, Marta BILIK, Anna BANDZAREWICZ, Malgorzata DOROBEK, Justyna ZIELINSKA-TUREK, Marta NOWAKOWSKA-KOTAS, Krystian OBARA, Pawel URBANOWSKI, Slawomir BUDREWICZ, Maciej GUZINSKI, Milena SWITONSKA, Iwona RUTKOWSKA, Paulina M SOBIESZAK-SKURA, Beata LABUZ-ROSZAK, Aleksander DEBIEC, Jacek STASZEWSKI, Adam STEPIEN, Jacek ZWIERNIK, Grzegorz WASILEWSKI, Cristina TIU, Elena Oana TERECOASA, Razvan Alexandru RADU, Anca NEGRILA, Bogdan DOROBAT, Cristina PANEA, Vlad TIU, Simona PETRESCU, Atilla OZDEMIR, Mostafa MAHMOUD, Hussam EL-SAMAHY, Hazem ABDELKHALEK, Jasem AL-HASHEL, Ismail Ibrahim ISMAIL, Athari SALMEEN, Abdoreza GHOREISHI, Sergiu Ionut SABETAY, Hana GROSS, Piers KLEIN, Mohamad ABDALKADER, Pascal JABBOUR, El Naamani KAREEM, Stavropoula TJOUMAKARIS, Rawad A ABBAS, Ghada MOHAMED, Alex CHEBL, Jiangyong MIN, Majesta P HOVINGH, Jenney TSAI, Muhib KHAN, Krishna NALLEBALLE, Sanjeeva ONTEDDU, Hesham MASOUD, Michael MINA, Navreet KAUR, Laith G MAALI, Michael ABRAHAM, Priyank KHANDELWAL, Ivo BACH, Melody ONG, Denis M BABICI, Ayaz KHAWAJA, Maryam HAKEMI, Kumar RAJAMANI, Vanessa CANO-NIGENDA, Antonio ARAUZ, Pablo AMAYA, Natalia LLANOS, Akemi ARANGO, Miguel Angel VENCES, Barrientos Guerra Jose DOMINGUO, Rayllene CAETANO, Rodrigo Targa MARTINS, Sergio Daniel SCOLLO, Patrick Matic YALUNG, Shashank NAGENDRA, Abhijit GAIKWAD, Kwon-Duk SEO, Georgios G GEORGIOPOULOS, Raul NOGUEIRA and Patrik MICHEL. Safety and Outcome of Revascularization Treatment in Patients With Acute Ischemic Stroke and COVID-19 The Global COVID-19 Stroke Registry. Neurology. Philadelphia: LIPPINCOTT WILLIAMS & WILKINS, 2023, vol. 100, No 7, p. "E739"-"E750", 12 pp. ISSN 0028-3878. Available from: https://dx.doi.org/10.1212/WNL.0000000000201537.
@article{2359141, author = {Marto, Joao Pedro and Strambo, Davide N and Ntaios, George and Nguyen, Thanh and Herzig, Roman and Czlonkowska, Anna and Demeestere, Jelle and Mansour, Ossama Yassin and Salerno, Alexander and Wegener, Susanne W and Baumgartner, Philipp and Cereda, Carlo and Bianco, Giovanni and Beyeler, Morin and Arnold, Marcel and Carrera, Emmanuel and Machi, Paolo and Altersberger, Valerian and Bonati, Leo and Gensicke, Henrik and Bolognese, Manuel and Peters, Nils and Wetzel, Stephan and Magrico, Marta and Ramos, Joao Nuno and SargentoandFreitas, Joao and Machado, Rita and Maia, Carolina and Machado, Egidio and Nunes, Ana Paiva and Ferreira, Patricia and Teresa, Pinho e Melo and Dias, Mariana Carvalho and Paula, Andre and Correia, Manuel Alberto and Castro, Pedro and Azevedo, Elsa and Albuquerque, Luis and Alves, Jose Nuno and FerreiraandPinto, Joana and Meira, Torcato and Pereira, Liliana and Rodrigues, Miguel and Araujo, Andre Pinho and Rodrigues, Marta and Rocha, Mariana and PereiraandFonseca, Angelo and Ribeiro, Luis and Varela, Ricardo and Malheiro, Sofia and Cappellari, Manuel and Zivelonghi, Cecilia and Sajeva, Giulia and Zini, Andrea and Gentile, Mauro and Forlivesi, Stefano and Migliaccio, Ludovica and Sessa, Maria and Sara, La Gioia and Pezzini, Alessandro and Sangalli, Davide and Zedde, Marialuisa and Pascarella, Rosario and Ferrarese, Carlo and Beretta, Simone and Diamanti, Susanna and Schwarz, Ghil and Frisullo, Giovanni and Marcheselli, Simona and Seners, Pierre and Sabben, Candice and Escalard, Simon and Piotin, Michel and Maier, Benjamin and Charbonnier, Guillaume and Vuillier, Fabrice and Legris, Loic R and Cuisenier, Pauline and Vodret, Francesca and Marnat, Gaultier and Liegey, JeanandSebastien and Sibon, Igor and Flottmann, Fabian and Broocks, Gabriel O and Gloyer, NilsandOle and Bohmann, Ferdinand and Schaefer, Jan Hendrik J and Nolte, Christian and Audebert, Heinrich and Siebert, Eberhard and Sykora, Marek and Lang, Wilfried and Ferrari, Julia and MayerandSuess, Lukas and Knoflach, Michael and Gizewski, Elke Ruth J and Stolp, Jeffrey M and Stolze, Lotte and Coutinho, Jonathan and Nederkoorn, Paul and Ido, van den Wijngaard and Joke, De Meris and Lemmens, Robin and Sylvie, De Raedt and Vandervorst, Fenne and Rutgers, Matthieu Pierre and Guilmot, Antoine and Dusart, Anne and Bellante, Flavio and CallejaandCastano, Patricia and Ostos, Fernando and GonzalezandOrtega, Guillermo and MartinandJimenez, Paloma and GarciaandMadrona, Sebastian and CruzandCulebras, Antonio and Vera, Rocio and Matute, Maria Consuelo and Fuentes, Blanca and AlonsoanddeandLecinana, Maria and Rigual, Ricardo and DiezandTejedor, Exuperio and PerezandSanchez, Soledad and Montaner, Joan and DiazandOtero, Fernando and PerezanddeandlaandOssa, Natalia and FloresandPina, Belen and MunozandNarbona, Lucia and Chamorro, Angel and RodriguezandVazquez, Alejandro and Renu, Arturo and AyoandMartin, Oscar and HernandezandFernandez, Francisco and Segura, Tomas and TejadaandMeza, Herbert and SagarraandMur, Daniel and SerranoandPonz, Marta and Hlaing, Thant and See, Isaiah and Simister, Robert and Werring, David and Kristoffersen, Espen Saxhaug and Nordanstig, Annika and Jood, Katarina and Rentzos, Alexandros and Simunek, Libor and Krajickova, Dagmar and Krajina, Antonín and Mikulík, Robert and Cviková, Martina and Vinklárek, Jan and Skoloudik, David and Roubec, Martin and Hurtikova, Eva and Hruby, Rostislav and Ostry, Svatopluk and Skoda, Ondrej and Pernicka, Marek and Jurak, Lubomir and Eichlova, Zuzana and Jira, Martin and Kovar, Martin and Pansky, Michal and Mencl, Pavel and Palouskova, Hana and Tomek, Ales and Jansky, Petr and Olserova, Anna and Sramek, Martin and Havlicek, Roman and Maly, Petr and Trakal, Lukas and Fiksa, Jan and Slovak, Matej and Karlinski, Michal Adam and Nowak, Maciej and SienkiewiczandJarosz, Halina and Bochynska, Anna and Wrona, Pawel and Homa, Tomasz et al.}, article_location = {Philadelphia}, article_number = {7}, doi = {http://dx.doi.org/10.1212/WNL.0000000000201537}, keywords = {THROMBECTOMY; COVID19; endovascular treatment; STROKE}, language = {eng}, issn = {0028-3878}, journal = {Neurology}, title = {Safety and Outcome of Revascularization Treatment in Patients With Acute Ischemic Stroke and COVID-19 The Global COVID-19 Stroke Registry}, url = {https://www.neurology.org/doi/10.1212/wnl.0000000000201537}, volume = {100}, year = {2023} }
TY - JOUR ID - 2359141 AU - Marto, Joao Pedro - Strambo, Davide N - Ntaios, George - Nguyen, Thanh - Herzig, Roman - Czlonkowska, Anna - Demeestere, Jelle - Mansour, Ossama Yassin - Salerno, Alexander - Wegener, Susanne W - Baumgartner, Philipp - Cereda, Carlo - Bianco, Giovanni - Beyeler, Morin - Arnold, Marcel - Carrera, Emmanuel - Machi, Paolo - Altersberger, Valerian - Bonati, Leo - Gensicke, Henrik - Bolognese, Manuel - Peters, Nils - Wetzel, Stephan - Magrico, Marta - Ramos, Joao Nuno - Sargento-Freitas, Joao - Machado, Rita - Maia, Carolina - Machado, Egidio - Nunes, Ana Paiva - Ferreira, Patricia - Teresa, Pinho e Melo - Dias, Mariana Carvalho - Paula, Andre - Correia, Manuel Alberto - Castro, Pedro - Azevedo, Elsa - Albuquerque, Luis - Alves, Jose Nuno - Ferreira-Pinto, Joana - Meira, Torcato - Pereira, Liliana - Rodrigues, Miguel - Araujo, Andre Pinho - Rodrigues, Marta - Rocha, Mariana - Pereira-Fonseca, Angelo - Ribeiro, Luis - Varela, Ricardo - Malheiro, Sofia - Cappellari, Manuel - Zivelonghi, Cecilia - Sajeva, Giulia - Zini, Andrea - Gentile, Mauro - Forlivesi, Stefano - Migliaccio, Ludovica - Sessa, Maria - Sara, La Gioia - Pezzini, Alessandro - Sangalli, Davide - Zedde, Marialuisa - Pascarella, Rosario - Ferrarese, Carlo - Beretta, Simone - Diamanti, Susanna - Schwarz, Ghil - Frisullo, Giovanni - Marcheselli, Simona - Seners, Pierre - Sabben, Candice - Escalard, Simon - Piotin, Michel - Maier, Benjamin - Charbonnier, Guillaume - Vuillier, Fabrice - Legris, Loic R - Cuisenier, Pauline - Vodret, Francesca - Marnat, Gaultier - Liegey, Jean-Sebastien - Sibon, Igor - Flottmann, Fabian - Broocks, Gabriel O - Gloyer, Nils-Ole - Bohmann, Ferdinand - Schaefer, Jan Hendrik J - Nolte, Christian - Audebert, Heinrich - Siebert, Eberhard - Sykora, Marek - Lang, Wilfried - Ferrari, Julia - Mayer-Suess, Lukas - Knoflach, Michael - Gizewski, Elke Ruth J - Stolp, Jeffrey M - Stolze, Lotte - Coutinho, Jonathan - Nederkoorn, Paul - Ido, van den Wijngaard - Joke, De Meris - Lemmens, Robin - Sylvie, De Raedt - Vandervorst, Fenne - Rutgers, Matthieu Pierre - Guilmot, Antoine - Dusart, Anne - Bellante, Flavio - Calleja-Castano, Patricia - Ostos, Fernando - Gonzalez-Ortega, Guillermo - Martin-Jimenez, Paloma - Garcia-Madrona, Sebastian - Cruz-Culebras, Antonio - Vera, Rocio - Matute, Maria Consuelo - Fuentes, Blanca - Alonso-de-Lecinana, Maria - Rigual, Ricardo - Diez-Tejedor, Exuperio - Perez-Sanchez, Soledad - Montaner, Joan - Diaz-Otero, Fernando - Perez-de-la-Ossa, Natalia - Flores-Pina, Belen - Munoz-Narbona, Lucia - Chamorro, Angel - Rodriguez-Vazquez, Alejandro - Renu, Arturo - Ayo-Martin, Oscar - Hernandez-Fernandez, Francisco - Segura, Tomas - Tejada-Meza, Herbert - Sagarra-Mur, Daniel - Serrano-Ponz, Marta - Hlaing, Thant - See, Isaiah - Simister, Robert - Werring, David - Kristoffersen, Espen Saxhaug - Nordanstig, Annika - Jood, Katarina - Rentzos, Alexandros - Simunek, Libor - Krajickova, Dagmar - Krajina, Antonín - Mikulík, Robert - Cviková, Martina - Vinklárek, Jan - Skoloudik, David - Roubec, Martin - Hurtikova, Eva - Hruby, Rostislav - Ostry, Svatopluk - Skoda, Ondrej - Pernicka, Marek - Jurak, Lubomir - Eichlova, Zuzana - Jira, Martin - Kovar, Martin - Pansky, Michal - Mencl, Pavel - Palouskova, Hana - Tomek, Ales - Jansky, Petr - Olserova, Anna - Sramek, Martin - Havlicek, Roman - Maly, Petr - Trakal, Lukas - Fiksa, Jan - Slovak, Matej - Karlinski, Michal Adam - Nowak, Maciej - Sienkiewicz-Jarosz, Halina - Bochynska, Anna - Wrona, Pawel - Homa, Tomasz et al. PY - 2023 TI - Safety and Outcome of Revascularization Treatment in Patients With Acute Ischemic Stroke and COVID-19 The Global COVID-19 Stroke Registry JF - Neurology VL - 100 IS - 7 SP - "E739"-"E750" EP - "E739"-"E750" PB - LIPPINCOTT WILLIAMS & WILKINS SN - 00283878 KW - THROMBECTOMY KW - COVID19 KW - endovascular treatment KW - STROKE UR - https://www.neurology.org/doi/10.1212/wnl.0000000000201537 N2 - Background and ObjectivesCOVID-19-related inflammation, endothelial dysfunction, and coagulopathy may increase the bleeding risk and lower the efficacy of revascularization treatments in patients with acute ischemic stroke (AIS). We aimed to evaluate the safety and outcomes of revascularization treatments in patients with AIS and COVID-19.MethodsThis was a retrospective multicenter cohort study of consecutive patients with AIS receiving intravenous thrombolysis (IVT) and/or endovascular treatment (EVT) between March 2020 and June 2021 tested for severe acute respiratory syndrome coronavirus 2 infection. With a doubly robust model combining propensity score weighting and multivariate regression, we studied the association of COVID-19 with intracranial bleeding complications and clinical outcomes. Subgroup analyses were performed according to treatment groups (IVT-only and EVT).ResultsOf a total of 15,128 included patients from 105 centers, 853 (5.6%) were diagnosed with COVID-19; of those, 5,848 (38.7%) patients received IVT-only and 9,280 (61.3%) EVT (with or without IVT). Patients with COVID-19 had a higher rate of symptomatic intracerebral hemorrhage (SICH) (adjusted OR 1.53; 95% CI 1.16-2.01), symptomatic subarachnoid hemorrhage (SSAH) (OR 1.80; 95% CI 1.20-2.69), SICH and/or SSAH combined (OR 1.56; 95% CI 1.23-1.99), 24-hour mortality (OR 2.47; 95% CI 1.58-3.86), and 3-month mortality (OR 1.88; 95% CI 1.52-2.33). Patients with COVID-19 also had an unfavorable shift in the distribution of the modified Rankin score at 3 months (OR 1.42; 95% CI 1.26-1.60).DiscussionPatients with AIS and COVID-19 showed higher rates of intracranial bleeding complications and worse clinical outcomes after revascularization treatments than contemporaneous non-COVID-19 patients receiving treatment. Current available data do not allow direct conclusions to be drawn on the effectiveness of revascularization treatments in patients with COVID-19 or to establish different treatment recommendations in this subgroup of patients with ischemic stroke. Our findings can be taken into consideration for treatment decisions, patient monitoring, and establishing prognosis. ER -
MARTO, Joao Pedro, Davide N STRAMBO, George NTAIOS, Thanh NGUYEN, Roman HERZIG, Anna CZLONKOWSKA, Jelle DEMEESTERE, Ossama Yassin MANSOUR, Alexander SALERNO, Susanne W WEGENER, Philipp BAUMGARTNER, Carlo CEREDA, Giovanni BIANCO, Morin BEYELER, Marcel ARNOLD, Emmanuel CARRERA, Paolo MACHI, Valerian ALTERSBERGER, Leo BONATI, Henrik GENSICKE, Manuel BOLOGNESE, Nils PETERS, Stephan WETZEL, Marta MAGRICO, Joao Nuno RAMOS, Joao SARGENTO-FREITAS, Rita MACHADO, Carolina MAIA, Egidio MACHADO, Ana Paiva NUNES, Patricia FERREIRA, Pinho e Melo TERESA, Mariana Carvalho DIAS, Andre PAULA, Manuel Alberto CORREIA, Pedro CASTRO, Elsa AZEVEDO, Luis ALBUQUERQUE, Jose Nuno ALVES, Joana FERREIRA-PINTO, Torcato MEIRA, Liliana PEREIRA, Miguel RODRIGUES, Andre Pinho ARAUJO, Marta RODRIGUES, Mariana ROCHA, Angelo PEREIRA-FONSECA, Luis RIBEIRO, Ricardo VARELA, Sofia MALHEIRO, Manuel CAPPELLARI, Cecilia ZIVELONGHI, Giulia SAJEVA, Andrea ZINI, Mauro GENTILE, Stefano FORLIVESI, Ludovica MIGLIACCIO, Maria SESSA, La Gioia SARA, Alessandro PEZZINI, Davide SANGALLI, Marialuisa ZEDDE, Rosario PASCARELLA, Carlo FERRARESE, Simone BERETTA, Susanna DIAMANTI, Ghil SCHWARZ, Giovanni FRISULLO, Simona MARCHESELLI, Pierre SENERS, Candice SABBEN, Simon ESCALARD, Michel PIOTIN, Benjamin MAIER, Guillaume CHARBONNIER, Fabrice VUILLIER, Loic R LEGRIS, Pauline CUISENIER, Francesca VODRET, Gaultier MARNAT, Jean-Sebastien LIEGEY, Igor SIBON, Fabian FLOTTMANN, Gabriel O BROOCKS, Nils-Ole GLOYER, Ferdinand BOHMANN, Jan Hendrik J SCHAEFER, Christian NOLTE, Heinrich AUDEBERT, Eberhard SIEBERT, Marek SYKORA, Wilfried LANG, Julia FERRARI, Lukas MAYER-SUESS, Michael KNOFLACH, Elke Ruth J GIZEWSKI, Jeffrey M STOLP, Lotte STOLZE, Jonathan COUTINHO, Paul NEDERKOORN, van den Wijngaard IDO, De Meris JOKE, Robin LEMMENS, De Raedt SYLVIE, Fenne VANDERVORST, Matthieu Pierre RUTGERS, Antoine GUILMOT, Anne DUSART, Flavio BELLANTE, Patricia CALLEJA-CASTANO, Fernando OSTOS, Guillermo GONZALEZ-ORTEGA, Paloma MARTIN-JIMENEZ, Sebastian GARCIA-MADRONA, Antonio CRUZ-CULEBRAS, Rocio VERA, Maria Consuelo MATUTE, Blanca FUENTES, Maria ALONSO-DE-LECINANA, Ricardo RIGUAL, Exuperio DIEZ-TEJEDOR, Soledad PEREZ-SANCHEZ, Joan MONTANER, Fernando DIAZ-OTERO, Natalia PEREZ-DE-LA-OSSA, Belen FLORES-PINA, Lucia MUNOZ-NARBONA, Angel CHAMORRO, Alejandro RODRIGUEZ-VAZQUEZ, Arturo RENU, Oscar AYO-MARTIN, Francisco HERNANDEZ-FERNANDEZ, Tomas SEGURA, Herbert TEJADA-MEZA, Daniel SAGARRA-MUR, Marta SERRANO-PONZ, Thant HLAING, Isaiah SEE, Robert SIMISTER, David WERRING, Espen Saxhaug KRISTOFFERSEN, Annika NORDANSTIG, Katarina JOOD, Alexandros RENTZOS, Libor SIMUNEK, Dagmar KRAJICKOVA, Antonín KRAJINA, Robert MIKULÍK, Martina CVIKOVÁ, Jan VINKLÁREK, David SKOLOUDIK, Martin ROUBEC, Eva HURTIKOVA, Rostislav HRUBY, Svatopluk OSTRY, Ondrej SKODA, Marek PERNICKA, Lubomir JURAK, Zuzana EICHLOVA, Martin JIRA, Martin KOVAR, Michal PANSKY, Pavel MENCL, Hana PALOUSKOVA, Ales TOMEK, Petr JANSKY, Anna OLSEROVA, Martin SRAMEK, Roman HAVLICEK, Petr MALY, Lukas TRAKAL, Jan FIKSA, Matej SLOVAK, Michal Adam KARLINSKI, Maciej NOWAK, Halina SIENKIEWICZ-JAROSZ, Anna BOCHYNSKA, Pawel WRONA, Tomasz HOMA, Katarzyna SAWCZYNSKA, Agnieszka SLOWIK, Ewa WLODARCZYK, Marcin WIACEK, Izabella TOMASZEWSKA-LAMPART, Bartosz SIECZKOWSKI, Halina BARTOSIK-PSUJEK, Marta BILIK, Anna BANDZAREWICZ, Malgorzata DOROBEK, Justyna ZIELINSKA-TUREK, Marta NOWAKOWSKA-KOTAS, Krystian OBARA, Pawel URBANOWSKI, Slawomir BUDREWICZ, Maciej GUZINSKI, Milena SWITONSKA, Iwona RUTKOWSKA, Paulina M SOBIESZAK-SKURA, Beata LABUZ-ROSZAK, Aleksander DEBIEC, Jacek STASZEWSKI, Adam STEPIEN, Jacek ZWIERNIK, Grzegorz WASILEWSKI, Cristina TIU, Elena Oana TERECOASA, Razvan Alexandru RADU, Anca NEGRILA, Bogdan DOROBAT, Cristina PANEA, Vlad TIU, Simona PETRESCU, Atilla OZDEMIR, Mostafa MAHMOUD, Hussam EL-SAMAHY, Hazem ABDELKHALEK, Jasem AL-HASHEL, Ismail Ibrahim ISMAIL, Athari SALMEEN, Abdoreza GHOREISHI, Sergiu Ionut SABETAY, Hana GROSS, Piers KLEIN, Mohamad ABDALKADER, Pascal JABBOUR, El Naamani KAREEM, Stavropoula TJOUMAKARIS, Rawad A ABBAS, Ghada MOHAMED, Alex CHEBL, Jiangyong MIN, Majesta P HOVINGH, Jenney TSAI, Muhib KHAN, Krishna NALLEBALLE, Sanjeeva ONTEDDU, Hesham MASOUD, Michael MINA, Navreet KAUR, Laith G MAALI, Michael ABRAHAM, Priyank KHANDELWAL, Ivo BACH, Melody ONG, Denis M BABICI, Ayaz KHAWAJA, Maryam HAKEMI, Kumar RAJAMANI, Vanessa CANO-NIGENDA, Antonio ARAUZ, Pablo AMAYA, Natalia LLANOS, Akemi ARANGO, Miguel Angel VENCES, Barrientos Guerra Jose DOMINGUO, Rayllene CAETANO, Rodrigo Targa MARTINS, Sergio Daniel SCOLLO, Patrick Matic YALUNG, Shashank NAGENDRA, Abhijit GAIKWAD, Kwon-Duk SEO, Georgios G GEORGIOPOULOS, Raul NOGUEIRA and Patrik MICHEL. 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