The effect of deep brain stimulation in Parkinson's disease
reflected in EEG microstates

J 2023

The effect of deep brain stimulation in Parkinson's disease reflected in EEG microstates

LAMOŠ, Martin, Martina BOČKOVÁ, Sabina GOLDEMUNDOVÁ, Marek BALÁŽ, Jan CHRASTINA et. al.

Basic information

Original name

The effect of deep brain stimulation in Parkinson's disease reflected in EEG microstates

Authors

LAMOŠ, Martin (203 Czech Republic, belonging to the institution), Martina BOČKOVÁ (203 Czech Republic, belonging to the institution), Sabina GOLDEMUNDOVÁ (203 Czech Republic, belonging to the institution), Marek BALÁŽ (703 Slovakia, belonging to the institution), Jan CHRASTINA (203 Czech Republic, belonging to the institution) and Ivan REKTOR (203 Czech Republic, guarantor, belonging to the institution)

Edition

NPJ PARKINSONS DISEASE, BERLIN, NATURE PORTFOLIO, 2023, 2373-8057

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 8.700 in 2022

RIV identification code

RIV/00216224:14740/23:00132933

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1038/s41531-023-00508-x

UT WoS

000989780900001

Keywords in English

deep brain stimulation; high-density EEG; Parkinson's disease; EEG microstates

Abstract

V originále

Mechanisms of deep brain stimulation (DBS) on cortical networks were explored mainly by fMRI. Advanced analysis of high-density EEG is a source of additional information and may provide clinically useful biomarkers. The presented study evaluates EEG microstates in Parkinson's disease and the effect of DBS of the subthalamic nucleus (STN). The association between revealed spatiotemporal dynamics of brain networks and changes in oscillatory activity and clinical examination were assessed. Thirty-seven patients with Parkinson's disease treated by STN-DBS underwent two sessions (OFF and ON stimulation conditions) of resting-state EEG. EEG microstates were analyzed in patient recordings and in a matched healthy control dataset. Microstate parameters were then compared across groups and were correlated with clinical and neuropsychological scores. Of the five revealed microstates, two differed between Parkinson's disease patients and healthy controls. Another microstate differed between ON and OFF stimulation conditions in the patient group and restored parameters in the ON stimulation state toward to healthy values. The mean beta power of that microstate was the highest in patients during the OFF stimulation condition and the lowest in healthy controls; sources were localized mainly in the supplementary motor area. Changes in microstate parameters correlated with UPDRS and neuropsychological scores. Disease specific alterations in the spatiotemporal dynamics of large-scale brain networks can be described by EEG microstates. The approach can reveal changes reflecting the effect of DBS on PD motor symptoms as well as changes probably related to non-motor symptoms not influenced by DBS.

Links

NU21-04-00445, research and development project

Name: Klinická odpovídavost na STN-DBS u Parkinsonovy nemoci: vliv vaskulárních, kardiovaskulárních, metabolických a zánětlivých komorbidit (Acronym: DBScomorbidities)

Investor: Ministry of Health of the CR, STN-DBS outcomes in Parkinson´s disease: the influence of vascular, cardiovascular, metabolic, and inflammatory co-morbidities., Subprogram 1 - standard

90129, large research infrastructures

Name: Czech-BioImaging II

Citovat

LAMOŠ, Martin, Martina BOČKOVÁ, Sabina GOLDEMUNDOVÁ, Marek BALÁŽ, Jan CHRASTINA and Ivan REKTOR. The effect of deep brain stimulation in Parkinson's disease reflected in EEG microstates. NPJ PARKINSONS DISEASE. BERLIN: NATURE PORTFOLIO, 2023, vol. 9, No 1, p. 1-7. ISSN 2373-8057. Available from: https://dx.doi.org/10.1038/s41531-023-00508-x.

@article{2359337,
   author = {Lamoš, Martin and Bočková, Martina and Goldemundová, Sabina and Baláž, Marek and Chrastina, Jan and Rektor, Ivan},
   article_location = {BERLIN},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/s41531-023-00508-x},
   keywords = {deep brain stimulation; high-density EEG; Parkinson's disease; EEG microstates},
   language = {eng},
   issn = {2373-8057},
   journal = {NPJ PARKINSONS DISEASE},
   title = {The effect of deep brain stimulation in Parkinson's disease reflected in EEG microstates},
   url = {https://www.nature.com/articles/s41531-023-00508-x},
   volume = {9},
   year = {2023}
}

TY  - JOUR
ID  - 2359337
AU  - Lamoš, Martin - Bočková, Martina - Goldemundová, Sabina - Baláž, Marek - Chrastina, Jan - Rektor, Ivan
PY  - 2023
TI  - The effect of deep brain stimulation in Parkinson's disease reflected in EEG microstates
JF  - NPJ PARKINSONS DISEASE
VL  - 9
IS  - 1
SP  - 1-7
EP  - 1-7
PB  - NATURE PORTFOLIO
SN  - 23738057
KW  - deep brain stimulation
KW  - high-density EEG
KW  - Parkinson's disease
KW  - EEG microstates
UR  - https://www.nature.com/articles/s41531-023-00508-x
N2  - Mechanisms of deep brain stimulation (DBS) on cortical networks were explored mainly by fMRI. Advanced analysis of high-density EEG is a source of additional information and may provide clinically useful biomarkers. The presented study evaluates EEG microstates in Parkinson's disease and the effect of DBS of the subthalamic nucleus (STN). The association between revealed spatiotemporal dynamics of brain networks and changes in oscillatory activity and clinical examination were assessed. Thirty-seven patients with Parkinson's disease treated by STN-DBS underwent two sessions (OFF and ON stimulation conditions) of resting-state EEG. EEG microstates were analyzed in patient recordings and in a matched healthy control dataset. Microstate parameters were then compared across groups and were correlated with clinical and neuropsychological scores. Of the five revealed microstates, two differed between Parkinson's disease patients and healthy controls. Another microstate differed between ON and OFF stimulation conditions in the patient group and restored parameters in the ON stimulation state toward to healthy values. The mean beta power of that microstate was the highest in patients during the OFF stimulation condition and the lowest in healthy controls; sources were localized mainly in the supplementary motor area. Changes in microstate parameters correlated with UPDRS and neuropsychological scores. Disease specific alterations in the spatiotemporal dynamics of large-scale brain networks can be described by EEG microstates. The approach can reveal changes reflecting the effect of DBS on PD motor symptoms as well as changes probably related to non-motor symptoms not influenced by DBS.
ER  -

LAMOŠ, Martin, Martina BOČKOVÁ, Sabina GOLDEMUNDOVÁ, Marek BALÁŽ, Jan CHRASTINA and Ivan REKTOR. The effect of deep brain stimulation in Parkinson's disease reflected in EEG microstates. \textit{NPJ PARKINSONS DISEASE}. BERLIN: NATURE PORTFOLIO, 2023, vol.~9, No~1, p.~1-7. ISSN~2373-8057. Available from: https://dx.doi.org/10.1038/s41531-023-00508-x.

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