Foxo1-Rictor axis mediates adaptive increase in Akt activity
and cell survival during BCR inhibitor therapy in chronic
lymphocytic leukemia.

a 2023

Foxo1-Rictor axis mediates adaptive increase in Akt activity and cell survival during BCR inhibitor therapy in chronic lymphocytic leukemia.

HLAVÁČ, Kryštof; Laura ONDRIŠOVÁ; Václav ŠEDA; Eva HOFERKOVÁ; G. CHIODIN et. al.

Basic information

Original name

Foxo1-Rictor axis mediates adaptive increase in Akt activity and cell survival during BCR inhibitor therapy in chronic lymphocytic leukemia.

Authors

HLAVÁČ, Kryštof (203 Czech Republic); Laura ONDRIŠOVÁ (703 Slovakia, belonging to the institution); Václav ŠEDA (203 Czech Republic, belonging to the institution); Eva HOFERKOVÁ; G. CHIODIN; Lenka KOŠŤÁLOVÁ (203 Czech Republic, belonging to the institution); Gabriela MLADONICKÁ PAVLASOVÁ (203 Czech Republic, belonging to the institution); Daniel FILIP (703 Slovakia, belonging to the institution); Pedro FARIA ZENI (76 Brazil, belonging to the institution); Jan OPPELT (203 Czech Republic, belonging to the institution); Anna PANOVSKÁ (203 Czech Republic, belonging to the institution); Karla PLEVOVÁ (203 Czech Republic, belonging to the institution); Šárka POSPÍŠILOVÁ (203 Czech Republic, belonging to the institution); M. ŠIMKOVIČ; F. VRBACKÝ; Daniel LYSÁK (203 Czech Republic); SM. FERNANDES; MS. DAVIDS; A. MAIQUES-DIAZ; S. CHARALAMPOPOULOU; I. MARTIN-SUBERO; JR. BROWN; Michael DOUBEK (203 Czech Republic, belonging to the institution); Francesco FORCONI; Jiří MAYER (203 Czech Republic, belonging to the institution) and Marek MRÁZ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Czech Annual Cancer Research Meeting, Olomouc, 2023

Other information

Language

English

Type of outcome

Conference abstract

Field of Study

30204 Oncology

Country of publisher

Czech Republic

Confidentiality degree

is not subject to a state or trade secret

References:

URL

RIV identification code

RIV/00216224:14740/23:00132964

Organization unit

Central European Institute of Technology

Keywords in English

BCR inhibitors; CLL; PI3K-Akt activation

Abstract

V originále

Genetic resistance mechanisms to BCR inhibitors in CLL have been extensively described, but it remains unclear whether non-genetic adaptation might exist in CLL cells allowing for lasting lymphocytosis or resistance. We focused on the possible role of the Akt pathway in adapting to BCR inhibitors since, in mouse models, PI3K-Akt activation is the only known factor that rescues the apoptosis induced by BCR deletion in mature B cells.

Links

LX22NPO5102, research and development project

Name: Národní ústav pro výzkum rakoviny (Acronym: NÚVR)

Investor: Ministry of Education, Youth and Sports of the CR, National institute for cancer research, 5.1 EXCELES

MUNI/A/1224/2022, interní kód MU

Name: Nové přístupy ve výzkumu, diagnostice a terapii hematologických malignit X

Investor: Masaryk University

NV18-03-00054, research and development project

Name: ÚLOHA MICRORNA A JEJICH CÍLOVÝCH MOLEKUL V TRANSFORMACI FOLIKULÁRNÍHO LYMFOMU A AGRESIVITĚ CHRONICKÉ LYMFOCYTÁRNÍ LEUKÉMIE

Investor: Ministry of Health of the CR

802644, interní kód MU

Name: Signaling propensity in the microenvironment of B cell chronic lymphocytic leukemia (Acronym: LeukemiaEnviron)

Investor: European Union, ERC (Excellent Science)

Files attached

cacr23_abstrakta_web_2.pdf

Cite

HLAVÁČ, Kryštof; Laura ONDRIŠOVÁ; Václav ŠEDA; Eva HOFERKOVÁ; G. CHIODIN; Lenka KOŠŤÁLOVÁ; Gabriela MLADONICKÁ PAVLASOVÁ; Daniel FILIP; Pedro FARIA ZENI; Jan OPPELT; Anna PANOVSKÁ; Karla PLEVOVÁ; Šárka POSPÍŠILOVÁ; M. ŠIMKOVIČ; F. VRBACKÝ; Daniel LYSÁK; SM. FERNANDES; MS. DAVIDS; A. MAIQUES-DIAZ; S. CHARALAMPOPOULOU; I. MARTIN-SUBERO; JR. BROWN; Michael DOUBEK; Francesco FORCONI; Jiří MAYER and Marek MRÁZ. Foxo1-Rictor axis mediates adaptive increase in Akt activity and cell survival during BCR inhibitor therapy in chronic lymphocytic leukemia. In Czech Annual Cancer Research Meeting, Olomouc. 2023.

@proceedings{2359957,
   author = {Hlaváč, Kryštof and Ondrišová, Laura and Šeda, Václav and Hoferková, Eva and Chiodin, G. and Košťálová, Lenka and Mladonická Pavlasová, Gabriela and Filip, Daniel and Faria Zeni, Pedro and Oppelt, Jan and Panovská, Anna and Plevová, Karla and Pospíšilová, Šárka and Šimkovič, M. and Vrbacký, F. and Lysák, Daniel and Fernandes, SM. and Davids, MS. and MaiquesandDiaz, A. and Charalampopoulou, S. and MartinandSubero, I. and Brown, JR. and Doubek, Michael and Forconi, Francesco and Mayer, Jiří and Mráz, Marek},
   booktitle = {Czech Annual Cancer Research Meeting, Olomouc},
   keywords = {BCR inhibitors; CLL; PI3K-Akt activation},
   language = {eng},
   title = {Foxo1-Rictor axis mediates adaptive increase in Akt activity and cell survival during BCR inhibitor therapy in chronic lymphocytic leukemia.},
   url = {https://cancermeeting.cz/czech-annual-cancer-research-meeting-2023/},
   year = {2023}
}

TY  - CONF
ID  - 2359957
AU  - Hlaváč, Kryštof - Ondrišová, Laura - Šeda, Václav - Hoferková, Eva - Chiodin, G. - Košťálová, Lenka - Mladonická Pavlasová, Gabriela - Filip, Daniel - Faria Zeni, Pedro - Oppelt, Jan - Panovská, Anna - Plevová, Karla - Pospíšilová, Šárka - Šimkovič, M. - Vrbacký, F. - Lysák, Daniel - Fernandes, SM. - Davids, MS. - Maiques-Diaz, A. - Charalampopoulou, S. - Martin-Subero, I. - Brown, JR. - Doubek, Michael - Forconi, Francesco - Mayer, Jiří - Mráz, Marek
PY  - 2023
TI  - Foxo1-Rictor axis mediates adaptive increase in Akt activity and cell survival during BCR inhibitor therapy in chronic lymphocytic leukemia.
KW  - BCR inhibitors
KW  - CLL
KW  - PI3K-Akt activation
UR  - https://cancermeeting.cz/czech-annual-cancer-research-meeting-2023/
N2  - Genetic resistance mechanisms to BCR inhibitors in CLL have been extensively described, but it remains unclear whether non-genetic adaptation might exist in CLL cells allowing for lasting lymphocytosis or resistance. We focused on the possible role of the Akt pathway in adapting to BCR inhibitors since, in mouse models, PI3K-Akt activation is the only known factor that rescues the apoptosis induced by BCR deletion in mature B cells.
ER  -

HLAVÁČ, Kryštof; Laura ONDRIŠOVÁ; Václav ŠEDA; Eva HOFERKOVÁ; G. CHIODIN; Lenka KOŠŤÁLOVÁ; Gabriela MLADONICKÁ PAVLASOVÁ; Daniel FILIP; Pedro FARIA ZENI; Jan OPPELT; Anna PANOVSKÁ; Karla PLEVOVÁ; Šárka POSPÍŠILOVÁ; M. ŠIMKOVIČ; F. VRBACKÝ; Daniel LYSÁK; SM. FERNANDES; MS. DAVIDS; A. MAIQUES-DIAZ; S. CHARALAMPOPOULOU; I. MARTIN-SUBERO; JR. BROWN; Michael DOUBEK; Francesco FORCONI; Jiří MAYER and Marek MRÁZ. Foxo1-Rictor axis mediates adaptive increase in Akt activity and cell survival during BCR inhibitor therapy in chronic lymphocytic leukemia. In \textit{Czech Annual Cancer Research Meeting, Olomouc}. 2023.

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