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@article{2360027,
author = {Samadian, Amir and Kratochvílová, Monika and Hokynková, Alica and Šín, Petr and Nováková, Marie and Štěpka, Petr and Pokorná, Andrea and Babula, Petr},
article_location = {Praha},
article_number = {Supplementum 5},
doi = {http://dx.doi.org/10.33549/physiolres.935222},
keywords = {Pressure ulcers; Debridement; Wound healing; Oxidative stress; Gene expression},
language = {eng},
issn = {0862-8408},
journal = {Physiological research},
title = {Changes in gene expression in pressure ulcers debrided by different approaches - a pilot study},
url = {https://www.biomed.cas.cz/physiolres/pdf/72/72_S535.pdf},
volume = {72},
year = {2023}
}
TY - JOUR
ID - 2360027
AU - Samadian, Amir - Kratochvílová, Monika - Hokynková, Alica - Šín, Petr - Nováková, Marie - Štěpka, Petr - Pokorná, Andrea - Babula, Petr
PY - 2023
TI - Changes in gene expression in pressure ulcers debrided by different approaches - a pilot study
JF - Physiological research
VL - 72
IS - Supplementum 5
SP - "S535"-"S542"
EP - "S535"-"S542"
PB - Institute of Physiology of the Czechoslovak Academy of Sciences
SN - 08628408
KW - Pressure ulcers
KW - Debridement
KW - Wound healing
KW - Oxidative stress
KW - Gene expression
UR - https://www.biomed.cas.cz/physiolres/pdf/72/72_S535.pdf
N2 - Pressure ulcers (PUs), also known as pressure injuries, are chronic wounds that represent potential lifelong complications. Pressure ulcers of a deep category (III and IV) are often indicated for surgical treatment - debridement and surgical reconstruction. Sharp surgical debridement is widely used in the debridement of PUs; however, the Versajet® hydrosurgery system is becoming an increasingly popular tool for tangential excision in surgery due to its numerous advantages. This work focused on the expression of selected genes, especially those associated with oxidative stress, in PUs debrided by two approaches - sharp surgical debridement and debridement using Versajet® hydrosurgery system. Expression of following genes was evaluated: NFE2L2, ACTA2, NFKB1, VEGFA, MKI67, HMOX1, HMOX2, HIF1A, and SOD2. ACTB and PSMB were used as housekeeping genes. So far, five patients have been enrolled in the study. Preliminary results suggest no significant difference in gene expression with different pressure ulcer treatment approaches except NFE2L2, despite the macroscopic differences. However, the results revealed correlations between the expression of some genes, namely HIF1A and SOD2, VEGFA and SOD2 and VEGFA and HIF1A. These results may indicate a connection between hypoxia, oxidative stress, pressure ulcer healing processes and angiogenesis.
ER -
SAMADIAN, Amir, Monika KRATOCHVÍLOVÁ, Alica HOKYNKOVÁ, Petr ŠÍN, Marie NOVÁKOVÁ, Petr ŠTĚPKA, Andrea POKORNÁ and Petr BABULA. Changes in gene expression in pressure ulcers debrided by different approaches - a pilot study. \textit{Physiological research}. Praha: Institute of Physiology of the Czechoslovak Academy of Sciences, 2023, vol.~72, Supplementum 5, p.~''S535''-''S542'', 8 pp. ISSN~0862-8408. Available from: https://dx.doi.org/10.33549/physiolres.935222.
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