A pilot study: Exploring the influence of COVID-19 on
cardiovascular physiology and retinal microcirculation

J 2023

A pilot study: Exploring the influence of COVID-19 on cardiovascular physiology and retinal microcirculation

SALOŇ, Adam, Ruslan NESHEV, Kaja TERAŽ, Boštjan ŠIMUNIČ, Manca PESKAR et. al.

Basic information

Original name

A pilot study: Exploring the influence of COVID-19 on cardiovascular physiology and retinal microcirculation

Authors

SALOŇ, Adam (703 Slovakia, belonging to the institution), Ruslan NESHEV, Kaja TERAŽ, Boštjan ŠIMUNIČ, Manca PESKAR, Uroš MARUŠIČ, Saša PIŠOT, Luka ŠLOSAR, Mladen GASPARINI, Rado PIŠOT, Patrick DE BOEVER, Karin SCHMID-ZALAUDEK, Bianca STEUBER, Per Morten FREDRIKSEN, Benedicta Ngwenchi NKEH-CHUNGAG, Harald SOURIJ, Omar ŠERÝ (203 Czech Republic, guarantor, belonging to the institution) and Nandu GOSWAMI

Edition

Microvascular Research, Academic Press Inc. 2023, 0026-2862

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30105 Physiology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.100 in 2022

RIV identification code

RIV/00216224:14310/23:00133041

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1016/j.mvr.2023.104588

UT WoS

001049715900001

Keywords in English

COVID-19; Circulation; Hemodynamics; Pulse wave analysis; Retina; Arterial stiffness; Microcirculation

Abstract

V originále

Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) affects the cardiovascular system. The current study investigated changes in heart rate (HR), blood pressure (BP), pulse wave velocity (PWV), and microcirculation in patients recovering from Coronavirus disease 2019 (COVID-19) infection. Methodology: Out of 43 initially contacted COVID-19 patients, 35 (30 males, 5 females; age: 60 ± 10 years; and body mass index (BMI): 31.8 ± 4.9) participated in this study. Participants were seen on two occasions after hospital discharge; the baseline measurements were collected, either on the day of hospital discharge if a negative PCR test was obtained, or on the 10th day after hospitalization if the PCR test was positive. The second measurements were done 60 days after hospitalization. The vascular measurements were performed using the VICORDER® device and a retinal blood vessel image analysis. Results: A significant increase in systolic BP (SBP) (from 142 mmHg, SD: 15, to 150 mmHg, SD: 19, p = 0.041), reduction in HR (from 76 bpm, SD: 15, to 69 bpm, SD: 11, p = 0.001), and narrower central retinal vein equivalent (CRVE) (from 240.94 μm, SD: 16.05, to 198.05 μm, SD: 17.36, p = 0.013) were found. Furthermore, the trends of increasing PWV (from 11 m/s, SD: 3, to 12 m/s, SD: 3, p = 0.095) and decreasing CRAE (from 138.87 μm, SD: 12.19, to 136.77 μm, SD: 13.19, p = 0.068) were recorded. Conclusion: The present study investigated cardiovascular changes following COVID-19 infection at two-time points after hospital discharge (baseline measurements and 60 days post-hospitalization). Significant changes were found in systolic blood pressure, heart rate, and microvasculature indicating that vascular adaptations may be ongoing even weeks after hospitalization from COVID-19 infection. Future studies could involve conducting additional interim assessments during the active infection and post-infection periods.

Citovat

SALOŇ, Adam, Ruslan NESHEV, Kaja TERAŽ, Boštjan ŠIMUNIČ, Manca PESKAR, Uroš MARUŠIČ, Saša PIŠOT, Luka ŠLOSAR, Mladen GASPARINI, Rado PIŠOT, Patrick DE BOEVER, Karin SCHMID-ZALAUDEK, Bianca STEUBER, Per Morten FREDRIKSEN, Benedicta Ngwenchi NKEH-CHUNGAG, Harald SOURIJ, Omar ŠERÝ and Nandu GOSWAMI. A pilot study: Exploring the influence of COVID-19 on cardiovascular physiology and retinal microcirculation. Microvascular Research. Academic Press Inc., 2023, vol. 150, November, p. 1-7. ISSN 0026-2862. Available from: https://dx.doi.org/10.1016/j.mvr.2023.104588.

@article{2361517,
   author = {Saloň, Adam and Neshev, Ruslan and Teraž, Kaja and Šimunič, Boštjan and Peskar, Manca and Marušič, Uroš and Pišot, Saša and Šlosar, Luka and Gasparini, Mladen and Pišot, Rado and De Boever, Patrick and SchmidandZalaudek, Karin and Steuber, Bianca and Fredriksen, Per Morten and NkehandChungag, Benedicta Ngwenchi and Sourij, Harald and Šerý, Omar and Goswami, Nandu},
   article_number = {November},
   doi = {http://dx.doi.org/10.1016/j.mvr.2023.104588},
   keywords = {COVID-19; Circulation; Hemodynamics; Pulse wave analysis; Retina; Arterial stiffness; Microcirculation},
   language = {eng},
   issn = {0026-2862},
   journal = {Microvascular Research},
   title = {A pilot study: Exploring the influence of COVID-19 on cardiovascular physiology and retinal microcirculation},
   url = {https://doi.org/10.1016/j.mvr.2023.104588},
   volume = {150},
   year = {2023}
}

TY  - JOUR
ID  - 2361517
AU  - Saloň, Adam - Neshev, Ruslan - Teraž, Kaja - Šimunič, Boštjan - Peskar, Manca - Marušič, Uroš - Pišot, Saša - Šlosar, Luka - Gasparini, Mladen - Pišot, Rado - De Boever, Patrick - Schmid-Zalaudek, Karin - Steuber, Bianca - Fredriksen, Per Morten - Nkeh-Chungag, Benedicta Ngwenchi - Sourij, Harald - Šerý, Omar - Goswami, Nandu
PY  - 2023
TI  - A pilot study: Exploring the influence of COVID-19 on cardiovascular physiology and retinal microcirculation
JF  - Microvascular Research
VL  - 150
IS  - November
SP  - 1-7
EP  - 1-7
PB  - Academic Press Inc.
SN  - 00262862
KW  - COVID-19
KW  - Circulation
KW  - Hemodynamics
KW  - Pulse wave analysis
KW  - Retina
KW  - Arterial stiffness
KW  - Microcirculation
UR  - https://doi.org/10.1016/j.mvr.2023.104588
N2  - Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) affects the cardiovascular system. The current study investigated changes in heart rate (HR), blood pressure (BP), pulse wave velocity (PWV), and microcirculation in patients recovering from Coronavirus disease 2019 (COVID-19) infection. Methodology: Out of 43 initially contacted COVID-19 patients, 35 (30 males, 5 females; age: 60 ± 10 years; and body mass index (BMI): 31.8 ± 4.9) participated in this study. Participants were seen on two occasions after hospital discharge; the baseline measurements were collected, either on the day of hospital discharge if a negative PCR test was obtained, or on the 10th day after hospitalization if the PCR test was positive. The second measurements were done 60 days after hospitalization. The vascular measurements were performed using the VICORDER® device and a retinal blood vessel image analysis. Results: A significant increase in systolic BP (SBP) (from 142 mmHg, SD: 15, to 150 mmHg, SD: 19, p = 0.041), reduction in HR (from 76 bpm, SD: 15, to 69 bpm, SD: 11, p = 0.001), and narrower central retinal vein equivalent (CRVE) (from 240.94 μm, SD: 16.05, to 198.05 μm, SD: 17.36, p = 0.013) were found. Furthermore, the trends of increasing PWV (from 11 m/s, SD: 3, to 12 m/s, SD: 3, p = 0.095) and decreasing CRAE (from 138.87 μm, SD: 12.19, to 136.77 μm, SD: 13.19, p = 0.068) were recorded. Conclusion: The present study investigated cardiovascular changes following COVID-19 infection at two-time points after hospital discharge (baseline measurements and 60 days post-hospitalization). Significant changes were found in systolic blood pressure, heart rate, and microvasculature indicating that vascular adaptations may be ongoing even weeks after hospitalization from COVID-19 infection. Future studies could involve conducting additional interim assessments during the active infection and post-infection periods.
ER  -

SALOŇ, Adam, Ruslan NESHEV, Kaja TERAŽ, Boštjan ŠIMUNIČ, Manca PESKAR, Uroš MARUŠIČ, Saša PIŠOT, Luka ŠLOSAR, Mladen GASPARINI, Rado PIŠOT, Patrick DE BOEVER, Karin SCHMID-ZALAUDEK, Bianca STEUBER, Per Morten FREDRIKSEN, Benedicta Ngwenchi NKEH-CHUNGAG, Harald SOURIJ, Omar ŠERÝ and Nandu GOSWAMI. A pilot study: Exploring the influence of COVID-19 on cardiovascular physiology and retinal microcirculation. \textit{Microvascular Research}. Academic Press Inc., 2023, vol.~150, November, p.~1-7. ISSN~0026-2862. Available from: https://dx.doi.org/10.1016/j.mvr.2023.104588.

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