Cold atmospheric plasma-enabled platelet vesicle incorporated
iron oxide nano-propellers for thrombolysis

J 2023

Cold atmospheric plasma-enabled platelet vesicle incorporated iron oxide nano-propellers for thrombolysis

JHENG, Pei-Ru, Chia-Che CHIANG, Jiunn-Horng KANG, Yu-Jui FAN, Kevin C. -W. WU et. al.

Basic information

Original name

Cold atmospheric plasma-enabled platelet vesicle incorporated iron oxide nano-propellers for thrombolysis

Authors

JHENG, Pei-Ru, Chia-Che CHIANG, Jiunn-Horng KANG, Yu-Jui FAN, Kevin C. -W. WU, Yan-Ting CHEN, Jia-Wei LIANG, Nima BOLOUKI (364 Islamic Republic of Iran, belonging to the institution), Jyh-Wei LEE, Jang-Hsing HSIEH and Er-Yuan CHUANG

Edition

Materials Today Bio, Elsevier, 2023, 2590-0064

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10305 Fluids and plasma physics

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 8.200 in 2022

RIV identification code

RIV/00216224:14310/23:00133048

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1016/j.mtbio.2023.100876

UT WoS

001128488200001

Keywords in English

Cold atmospheric plasma; Iron oxide; Platelet vesicle; Phototherapy; Magnetotherapy; Thrombolysis

Abstract

V originále

A new approach to treating vascular blockages has been developed to overcome the limitations of current thrombolytic therapies. This approach involves biosafety and multimodal plasma-derived theranostic platelet vesicle incorporating iron oxide constructed nano-propellers platformed technology that possesses fluorescent and magnetic features and manifold thrombus targeting modes. The platform is capable of being guided and visualized remotely to specifically target thrombi, and it can be activated using near-infrared phototherapy along with an actuated magnet for magnetotherapy. In a murine model of thrombus lesion, this proposed multimodal approach showed an approximately 80% reduction in thrombus residues. Moreover, the new strategy not only improves thrombolysis but also boosts the rate of lysis, making it a promising candidate for time-sensitive thrombolytic therapy.

Links

90097, large research infrastructures

Name: CEPLANT

Citovat

JHENG, Pei-Ru, Chia-Che CHIANG, Jiunn-Horng KANG, Yu-Jui FAN, Kevin C. -W. WU, Yan-Ting CHEN, Jia-Wei LIANG, Nima BOLOUKI, Jyh-Wei LEE, Jang-Hsing HSIEH and Er-Yuan CHUANG. Cold atmospheric plasma-enabled platelet vesicle incorporated iron oxide nano-propellers for thrombolysis. Materials Today Bio. Elsevier, 2023, vol. 23, December, p. 1-14. ISSN 2590-0064. Available from: https://dx.doi.org/10.1016/j.mtbio.2023.100876.

@article{2361677,
   author = {Jheng, PeiandRu and Chiang, ChiaandChe and Kang, JiunnandHorng and Fan, YuandJui and Wu, Kevin C. andW. and Chen, YanandTing and Liang, JiaandWei and Bolouki, Nima and Lee, JyhandWei and Hsieh, JangandHsing and Chuang, ErandYuan},
   article_number = {December},
   doi = {http://dx.doi.org/10.1016/j.mtbio.2023.100876},
   keywords = {Cold atmospheric plasma; Iron oxide; Platelet vesicle; Phototherapy; Magnetotherapy; Thrombolysis},
   language = {eng},
   issn = {2590-0064},
   journal = {Materials Today Bio},
   title = {Cold atmospheric plasma-enabled platelet vesicle incorporated iron oxide nano-propellers for thrombolysis},
   url = {https://doi.org/10.1016/j.mtbio.2023.100876},
   volume = {23},
   year = {2023}
}

TY  - JOUR
ID  - 2361677
AU  - Jheng, Pei-Ru - Chiang, Chia-Che - Kang, Jiunn-Horng - Fan, Yu-Jui - Wu, Kevin C. -W. - Chen, Yan-Ting - Liang, Jia-Wei - Bolouki, Nima - Lee, Jyh-Wei - Hsieh, Jang-Hsing - Chuang, Er-Yuan
PY  - 2023
TI  - Cold atmospheric plasma-enabled platelet vesicle incorporated iron oxide nano-propellers for thrombolysis
JF  - Materials Today Bio
VL  - 23
IS  - December
SP  - 1-14
EP  - 1-14
PB  - Elsevier
SN  - 25900064
KW  - Cold atmospheric plasma
KW  - Iron oxide
KW  - Platelet vesicle
KW  - Phototherapy
KW  - Magnetotherapy
KW  - Thrombolysis
UR  - https://doi.org/10.1016/j.mtbio.2023.100876
N2  - A new approach to treating vascular blockages has been developed to overcome the limitations of current thrombolytic therapies. This approach involves biosafety and multimodal plasma-derived theranostic platelet vesicle incorporating iron oxide constructed nano-propellers platformed technology that possesses fluorescent and magnetic features and manifold thrombus targeting modes. The platform is capable of being guided and visualized remotely to specifically target thrombi, and it can be activated using near-infrared phototherapy along with an actuated magnet for magnetotherapy. In a murine model of thrombus lesion, this proposed multimodal approach showed an approximately 80% reduction in thrombus residues. Moreover, the new strategy not only improves thrombolysis but also boosts the rate of lysis, making it a promising candidate for time-sensitive thrombolytic therapy.
ER  -

JHENG, Pei-Ru, Chia-Che CHIANG, Jiunn-Horng KANG, Yu-Jui FAN, Kevin C. -W. WU, Yan-Ting CHEN, Jia-Wei LIANG, Nima BOLOUKI, Jyh-Wei LEE, Jang-Hsing HSIEH and Er-Yuan CHUANG. Cold atmospheric plasma-enabled platelet vesicle incorporated iron oxide nano-propellers for thrombolysis. \textit{Materials Today Bio}. Elsevier, 2023, vol.~23, December, p.~1-14. ISSN~2590-0064. Available from: https://dx.doi.org/10.1016/j.mtbio.2023.100876.

Detailed Information on Publication Record