Vagus nerve stimulation as immunomodulatory therapy for stroke:
A comprehensive review

J 2024

Vagus nerve stimulation as immunomodulatory therapy for stroke: A comprehensive review

JELÍNEK, Matyáš, Jolana LIPKOVÁ and Kamil ĎURIŠ

Basic information

Original name

Vagus nerve stimulation as immunomodulatory therapy for stroke: A comprehensive review

Name in Czech

Stimulace nervus vagus jako imunomodulační terapie u cévní mozkové příhody

Authors

JELÍNEK, Matyáš (203 Czech Republic, belonging to the institution), Jolana LIPKOVÁ (203 Czech Republic, belonging to the institution) and Kamil ĎURIŠ (203 Czech Republic, belonging to the institution)

Edition

Experimental neurology, SAN DIEGO, ACADEMIC PRESS INC ELSEVIER SCIENCE, 2024, 0014-4886

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.300 in 2022

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.expneurol.2023.114628

UT WoS

001135087500001

Keywords (in Czech)

cévní mozková příhoda; zánět; stimulace nervus vagus; imunomodulační terapie

Keywords in English

stroke; inflammation; vagus nerve stimulation; immunomodulatory therapy

Abstract

V originále

Stroke is a devastating cerebrovascular pathology with high morbidity and mortality. Inflammation plays a central role in the pathophysiology of stroke. Vagus nerve stimulation (VNS) is a promising immunomodulatory method that has shown positive effects in stroke treatment, including neuroprotection, anti-apoptosis, anti-inflammation, antioxidation, reduced infarct volume, improved neurological scores, and promotion of M2 microglial polarization. In this review, we summarize the current knowledge about the vagus nerve's immunomodulatory effects through the cholinergic anti-inflammatory pathway (CAP) and provide a comprehensive assessment of the available experimental literature focusing on the use of VNS in stroke treatment.

Links

NU23-04-00382, research and development project

Name: Proteomická identifikace biomarkerů asociovaných s variabilitou IL-6 u aneurysmálního subarachnoidálního krvácení

Investor: Ministry of Health of the CR, Proteomic identification of biomarkers associated with IL-6 variability in aneurysmal subarachnoid hemorrhage, Subprogram 1 - standard

Citovat

JELÍNEK, Matyáš, Jolana LIPKOVÁ and Kamil ĎURIŠ. Vagus nerve stimulation as immunomodulatory therapy for stroke: A comprehensive review. Experimental neurology. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2024, vol. 372, February 2024, p. 1-12. ISSN 0014-4886. Available from: https://dx.doi.org/10.1016/j.expneurol.2023.114628.

@article{2362409,
   author = {Jelínek, Matyáš and Lipková, Jolana and Ďuriš, Kamil},
   article_location = {SAN DIEGO},
   article_number = {February 2024},
   doi = {http://dx.doi.org/10.1016/j.expneurol.2023.114628},
   keywords = {stroke; inflammation; vagus nerve stimulation; immunomodulatory therapy},
   language = {eng},
   issn = {0014-4886},
   journal = {Experimental neurology},
   title = {Vagus nerve stimulation as immunomodulatory therapy for stroke: A comprehensive review},
   url = {https://www.sciencedirect.com/science/article/pii/S0014488623003138?via%3Dihub},
   volume = {372},
   year = {2024}
}

TY  - JOUR
ID  - 2362409
AU  - Jelínek, Matyáš - Lipková, Jolana - Ďuriš, Kamil
PY  - 2024
TI  - Vagus nerve stimulation as immunomodulatory therapy for stroke: A comprehensive review
JF  - Experimental neurology
VL  - 372
IS  - February 2024
SP  - 1-12
EP  - 1-12
PB  - ACADEMIC PRESS INC ELSEVIER SCIENCE
SN  - 00144886
KW  - stroke
KW  - inflammation
KW  - vagus nerve stimulation
KW  - immunomodulatory therapy
UR  - https://www.sciencedirect.com/science/article/pii/S0014488623003138?via%3Dihub
N2  - Stroke is a devastating cerebrovascular pathology with high morbidity and mortality. Inflammation plays a central role in the pathophysiology of stroke. Vagus nerve stimulation (VNS) is a promising immunomodulatory method that has shown positive effects in stroke treatment, including neuroprotection, anti-apoptosis, anti-inflammation, antioxidation, reduced infarct volume, improved neurological scores, and promotion of M2 microglial polarization. In this review, we summarize the current knowledge about the vagus nerve's immunomodulatory effects through the cholinergic anti-inflammatory pathway (CAP) and provide a comprehensive assessment of the available experimental literature focusing on the use of VNS in stroke treatment.
ER  -

JELÍNEK, Matyáš, Jolana LIPKOVÁ and Kamil ĎURIŠ. Vagus nerve stimulation as immunomodulatory therapy for stroke: A comprehensive review. \textit{Experimental neurology}. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2024, vol.~372, February 2024, p.~1-12. ISSN~0014-4886. Available from: https://dx.doi.org/10.1016/j.expneurol.2023.114628.

Detailed Information on Publication Record