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@article{2362409,
author = {Jelínek, Matyáš and Lipková, Jolana and Ďuriš, Kamil},
article_location = {SAN DIEGO},
article_number = {February 2024},
doi = {http://dx.doi.org/10.1016/j.expneurol.2023.114628},
keywords = {stroke; inflammation; vagus nerve stimulation; immunomodulatory therapy},
language = {eng},
issn = {0014-4886},
journal = {Experimental neurology},
title = {Vagus nerve stimulation as immunomodulatory therapy for stroke: A comprehensive review},
url = {https://www.sciencedirect.com/science/article/pii/S0014488623003138?via%3Dihub},
volume = {372},
year = {2024}
}
TY - JOUR
ID - 2362409
AU - Jelínek, Matyáš - Lipková, Jolana - Ďuriš, Kamil
PY - 2024
TI - Vagus nerve stimulation as immunomodulatory therapy for stroke: A comprehensive review
JF - Experimental neurology
VL - 372
IS - February 2024
SP - 1-12
EP - 1-12
PB - ACADEMIC PRESS INC ELSEVIER SCIENCE
SN - 00144886
KW - stroke
KW - inflammation
KW - vagus nerve stimulation
KW - immunomodulatory therapy
UR - https://www.sciencedirect.com/science/article/pii/S0014488623003138?via%3Dihub
N2 - Stroke is a devastating cerebrovascular pathology with high morbidity and mortality. Inflammation plays a central role in the pathophysiology of stroke. Vagus nerve stimulation (VNS) is a promising immunomodulatory method that has shown positive effects in stroke treatment, including neuroprotection, anti-apoptosis, anti-inflammation, antioxidation, reduced infarct volume, improved neurological scores, and promotion of M2 microglial polarization. In this review, we summarize the current knowledge about the vagus nerve's immunomodulatory effects through the cholinergic anti-inflammatory pathway (CAP) and provide a comprehensive assessment of the available experimental literature focusing on the use of VNS in stroke treatment.
ER -
JELÍNEK, Matyáš, Jolana LIPKOVÁ and Kamil ĎURIŠ. Vagus nerve stimulation as immunomodulatory therapy for stroke: A comprehensive review. \textit{Experimental neurology}. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2024, vol.~372, February 2024, p.~1-12. ISSN~0014-4886. Available from: https://dx.doi.org/10.1016/j.expneurol.2023.114628.
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