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@article{2362940,
author = {Daďová, Petra and Mikulová, Antónia and Jaroušek, Radim and Chorvátová, Michaela and Uldrijan, Stjepan and Kubala, Lukáš},
article_number = {December},
doi = {http://dx.doi.org/10.1016/j.intimp.2023.111166},
keywords = {DEPENDENT PROTEIN-KINASE; CYCLIC-AMP; GENETIC ARCHITECTURE; PDE4 INHIBITOR; RESPONSES; MEMORY; NAIVE; LYMPHOCYTES; EXPRESSION; MODULATORS},
language = {eng},
issn = {1567-5769},
journal = {International Immunopharmacology},
title = {A forskolin-mediated increase in cAMP promotes T helper cell differentiation into the Th1 and Th2 subsets rather than into the Th17 subset},
url = {https://www.sciencedirect.com/science/article/pii/S1567576923014923},
volume = {125},
year = {2023}
}
TY - JOUR
ID - 2362940
AU - Daďová, Petra - Mikulová, Antónia - Jaroušek, Radim - Chorvátová, Michaela - Uldrijan, Stjepan - Kubala, Lukáš
PY - 2023
TI - A forskolin-mediated increase in cAMP promotes T helper cell differentiation into the Th1 and Th2 subsets rather than into the Th17 subset
JF - International Immunopharmacology
VL - 125
IS - December
SP - 1-15
EP - 1-15
PB - Elsevier
SN - 15675769
KW - DEPENDENT PROTEIN-KINASE
KW - CYCLIC-AMP
KW - GENETIC ARCHITECTURE
KW - PDE4 INHIBITOR
KW - RESPONSES
KW - MEMORY
KW - NAIVE
KW - LYMPHOCYTES
KW - EXPRESSION
KW - MODULATORS
UR - https://www.sciencedirect.com/science/article/pii/S1567576923014923
N2 - The adenylyl cyclase (AC) signaling pathway is suggested to be a key regulator of immune system functions. However, specific effects of cyclic adenosine mono -phosphate (cAMP) on T helper (Th) cell differentiation and functions are unclear. The involvement of cAMP in the Th cell differentiation program, in particular the development of Th1, Th2, and Th17 subsets, was evaluated employing forskolin (FSK), a labdane diterpene well known as an AC activator. FSK mediated an elevation in Th1-specific markers reinforcing the Th1 cell phenotype. The Th2 differentiation was supported by FSK, though cell metabolism was negatively affected. In contrast, the Th17 immunophenotype was severely suppressed leading to the highly specific upregulation of CXCL13. The causality between FSK-elicited cAMP production and the observed reinforcement of Th2 differentiation was established by using AC inhibitor 2 ',5 '-dideoxyadenosine, which reverted the FSK effects. Overall, an FSK-mediated cAMP increase affects Th1, Th2 and Th17 differentiation and can contribute to the identification of novel therapeutic targets for the treatment of Th cell-related pathological processes.
ER -
DAĎOVÁ, Petra, Antónia MIKULOVÁ, Radim JAROUŠEK, Michaela CHORVÁTOVÁ, Stjepan ULDRIJAN and Lukáš KUBALA. A forskolin-mediated increase in cAMP promotes T helper cell differentiation into the Th1 and Th2 subsets rather than into the Th17 subset. \textit{International Immunopharmacology}. Elsevier, 2023, vol.~125, December, p.~1-15. ISSN~1567-5769. Available from: https://dx.doi.org/10.1016/j.intimp.2023.111166.
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