Inflammatory response in sepsis and hemorrhagic stroke

J 2023

Inflammatory response in sepsis and hemorrhagic stroke

JELÍNEK, Matyáš and Kamil ĎURIŠ

Basic information

Original name

Inflammatory response in sepsis and hemorrhagic stroke

Authors

JELÍNEK, Matyáš (203 Czech Republic, belonging to the institution) and Kamil ĎURIŠ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Brain Hemorrhages, BEIJING, KeAi Communications Co. 2023, 2589-238X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

China

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

RIV identification code

RIV/00216224:14110/23:00133145

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.hest.2022.10.005

UT WoS

001128758500001

Keywords in English

Sepsis; Hemorrhagic stroke; Inflammation; Inflammatory response; Pathophysiology; Experimental models

Abstract

V originále

Exaggerated/deregulated inflammatory response is a major medical problem that is often associated with bad outcomes or even the death of the patient. Sepsis and severe hemorrhagic stroke are two illustrative examples because sepsis represents inflammation that is systemic initially, while stroke is initially a local pathology that in severe cases turns into systemic inflammation. There are clear differences between the two pathological conditions in terms of mechanisms and dynamics of inflammatory response at an early stage, while later the inflammatory response becomes uniform. This article aims to describe side-by-side sepsis and hemorrhagic stroke so that similar features and differences can stand out. We will describe the pathophysiological and clinical aspects of sepsis and hemorrhagic stroke, experimental models, the role of inflammation, and molecular mechanisms of inflammation in both conditions. Comparison of inflammatory response in these two model situations may lead to a better understanding of life-threatening conditions pathophysiology, in which the exaggeration/deregulation of the inflammatory response may occur with potentially severe consequences. This article is kept detailed to provide the reader with in-depth information, which should allow him to find the mechanisms of inflammatory response and to elaborate them by himself in the context of his particular needs.

Citovat

JELÍNEK, Matyáš and Kamil ĎURIŠ. Inflammatory response in sepsis and hemorrhagic stroke. Brain Hemorrhages. BEIJING: KeAi Communications Co., 2023, vol. 4, No 2, p. 96-107. ISSN 2589-238X. Available from: https://dx.doi.org/10.1016/j.hest.2022.10.005.

@article{2364577,
   author = {Jelínek, Matyáš and Ďuriš, Kamil},
   article_location = {BEIJING},
   article_number = {2},
   doi = {http://dx.doi.org/10.1016/j.hest.2022.10.005},
   keywords = {Sepsis; Hemorrhagic stroke; Inflammation; Inflammatory response; Pathophysiology; Experimental models},
   language = {eng},
   issn = {2589-238X},
   journal = {Brain Hemorrhages},
   title = {Inflammatory response in sepsis and hemorrhagic stroke},
   url = {https://www.sciencedirect.com/science/article/pii/S2589238X22000742},
   volume = {4},
   year = {2023}
}

TY  - JOUR
ID  - 2364577
AU  - Jelínek, Matyáš - Ďuriš, Kamil
PY  - 2023
TI  - Inflammatory response in sepsis and hemorrhagic stroke
JF  - Brain Hemorrhages
VL  - 4
IS  - 2
SP  - 96-107
EP  - 96-107
PB  - KeAi Communications Co.
SN  - 2589238X
KW  - Sepsis
KW  - Hemorrhagic stroke
KW  - Inflammation
KW  - Inflammatory response
KW  - Pathophysiology
KW  - Experimental models
UR  - https://www.sciencedirect.com/science/article/pii/S2589238X22000742
N2  - Exaggerated/deregulated inflammatory response is a major medical problem that is often associated with bad outcomes or even the death of the patient. Sepsis and severe hemorrhagic stroke are two illustrative examples because sepsis represents inflammation that is systemic initially, while stroke is initially a local pathology that in severe cases turns into systemic inflammation. There are clear differences between the two pathological conditions in terms of mechanisms and dynamics of inflammatory response at an early stage, while later the inflammatory response becomes uniform. This article aims to describe side-by-side sepsis and hemorrhagic stroke so that similar features and differences can stand out. We will describe the pathophysiological and clinical aspects of sepsis and hemorrhagic stroke, experimental models, the role of inflammation, and molecular mechanisms of inflammation in both conditions. Comparison of inflammatory response in these two model situations may lead to a better understanding of life-threatening conditions pathophysiology, in which the exaggeration/deregulation of the inflammatory response may occur with potentially severe consequences. This article is kept detailed to provide the reader with in-depth information, which should allow him to find the mechanisms of inflammatory response and to elaborate them by himself in the context of his particular needs.
ER  -

JELÍNEK, Matyáš and Kamil ĎURIŠ. Inflammatory response in sepsis and hemorrhagic stroke. \textit{Brain Hemorrhages}. BEIJING: KeAi Communications Co., 2023, vol.~4, No~2, p.~96-107. ISSN~2589-238X. Available from: https://dx.doi.org/10.1016/j.hest.2022.10.005.

Detailed Information on Publication Record