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@misc{2364737,
author = {Cígler, Petr and Bálek, Lukáš and Havlík, Jan and Krejčí, Pavel and Trantírek, Lukáš and Trantírková, Silvie},
keywords = {nanosized diamond crystals;nanodiamonds;fibroblast grow factors;extracellular signalling molecules;serum proteins},
language = {eng},
title = {Nanodiamonds as artificial proteins for regulation of a cell signalling system},
url = {https://patentimages.storage.googleapis.com/64/c2/0f/b4999a8f6602f4/US11744855.pdf},
year = {2023}
}
TY - PAT
ID - 2364737
AU - Cígler, Petr - Bálek, Lukáš - Havlík, Jan - Krejčí, Pavel - Trantírek, Lukáš - Trantírková, Silvie
PY - 2023
TI - Nanodiamonds as artificial proteins for regulation of a cell signalling system
KW - nanosized diamond crystals;nanodiamonds;fibroblast grow factors;extracellular signalling molecules;serum proteins
UR - https://patentimages.storage.googleapis.com/64/c2/0f/b4999a8f6602f4/US11744855.pdf
N2 - Here, we show that nanosized diamond crystals (nanodiamonds, NDs) without any synthetically installed (bio)organic interface enable the specific and efficient targeting of the family of extracellular signalling molecules known as fibroblast growth factors (FGFs). We found that at certain conditions the ND strongly associate with multiple FGF ligands present at sub-nanomolar concentrations and effectively neutralize the effects of FGF signalling in cells without interfering with other growth factor systems and serum proteins unrelated to FGFs.
ER -
CÍGLER, Petr, Lukáš BÁLEK, Jan HAVLÍK, Pavel KREJČÍ, Lukáš TRANTÍREK and Silvie TRANTÍRKOVÁ. \textit{Nanodiamonds as artificial proteins for regulation of a cell signalling system}. 2023.
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