A walk in the PARC: developing and implementing 21st century
chemical risk assessment in Europe

J 2023

A walk in the PARC: developing and implementing 21st century chemical risk assessment in Europe

MARX-STOELTING, P., G. RIVIERE, M. LUIJTEN, K. AIELLO-HOLDEN, N. BANDOW et. al.

Basic information

Original name

A walk in the PARC: developing and implementing 21st century chemical risk assessment in Europe

Authors

MARX-STOELTING, P., G. RIVIERE, M. LUIJTEN, K. AIELLO-HOLDEN, N. BANDOW, K. BAKEN, A. CANAS, A. CASTANO, S. DENYS, C. FILLOL, M. HERZLER, I. IAVICOLI, S. KARAKITSIOS, Jana KLÁNOVÁ (203 Czech Republic, belonging to the institution), M. KOLOSSA-GEHRING, A. KOUTSODIMOU, J. Lobo VICENTE, I. LYNCH, S. NAMORADO, S. NORAGER, A. PITTMAN, S. ROTTER, D. SARIGIANNIS, M. J. SILVA, J. THEUNIS, T. TRALAU, M. UHL, J. VAN KLAVEREN, L. WENDT-RASCH, E. WESTERHOLM, C. ROUSSELLE and P. SANDERS

Edition

Archives of Toxicology, Springer, 2023, 0340-5761

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10511 Environmental sciences

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 6.100 in 2022

RIV identification code

RIV/00216224:14310/23:00133174

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1007/s00204-022-03435-7

UT WoS

000916767000001

Keywords in English

Next-generation risk assessment (NGRA); Chemicals; Safety assessment; Exposure assessment; Hazard characterisation; Human biomonitoring (HBM); New approach methods (NAM)

Abstract

V originále

Current approaches for the assessment of environmental and human health risks due to exposure to chemical substances have served their purpose reasonably well. Nevertheless, the systems in place for different uses of chemicals are faced with various challenges, ranging from a growing number of chemicals to changes in the types of chemicals and materials produced. This has triggered global awareness of the need for a paradigm shift, which in turn has led to the publication of new concepts for chemical risk assessment and explorations of how to translate these concepts into pragmatic approaches. As a result, next-generation risk assessment (NGRA) is generally seen as the way forward. However, incorporating new scientific insights and innovative approaches into hazard and exposure assessments in such a way that regulatory needs are adequately met has appeared to be challenging. The European Partnership for the Assessment of Risks from Chemicals (PARC) has been designed to address various challenges associated with innovating chemical risk assessment. Its overall goal is to consolidate and strengthen the European research and innovation capacity for chemical risk assessment to protect human health and the environment. With around 200 participating organisations from all over Europe, including three European agencies, and a total budget of over 400 million euro, PARC is one of the largest projects of its kind. It has a duration of seven years and is coordinated by ANSES, the French Agency for Food, Environmental and Occupational Health and Safety.

Links

101057014, interní kód MU

Name: Partnership for the Assessment of Risks from Chemicals (Acronym: PARC)

Investor: European Union, Cluster 1 - Health

Citovat

MARX-STOELTING, P., G. RIVIERE, M. LUIJTEN, K. AIELLO-HOLDEN, N. BANDOW, K. BAKEN, A. CANAS, A. CASTANO, S. DENYS, C. FILLOL, M. HERZLER, I. IAVICOLI, S. KARAKITSIOS, Jana KLÁNOVÁ, M. KOLOSSA-GEHRING, A. KOUTSODIMOU, J. Lobo VICENTE, I. LYNCH, S. NAMORADO, S. NORAGER, A. PITTMAN, S. ROTTER, D. SARIGIANNIS, M. J. SILVA, J. THEUNIS, T. TRALAU, M. UHL, J. VAN KLAVEREN, L. WENDT-RASCH, E. WESTERHOLM, C. ROUSSELLE and P. SANDERS. A walk in the PARC: developing and implementing 21st century chemical risk assessment in Europe. Archives of Toxicology. Springer, 2023, vol. 97, No 3, p. 893-908. ISSN 0340-5761. Available from: https://dx.doi.org/10.1007/s00204-022-03435-7.

@article{2364798,
   author = {MarxandStoelting, P. and Riviere, G. and Luijten, M. and AielloandHolden, K. and Bandow, N. and Baken, K. and Canas, A. and Castano, A. and Denys, S. and Fillol, C. and Herzler, M. and Iavicoli, I. and Karakitsios, S. and Klánová, Jana and KolossaandGehring, M. and Koutsodimou, A. and Vicente, J. Lobo and Lynch, I. and Namorado, S. and Norager, S. and Pittman, A. and Rotter, S. and Sarigiannis, D. and Silva, M. J. and Theunis, J. and Tralau, T. and Uhl, M. and van Klaveren, J. and WendtandRasch, L. and Westerholm, E. and Rousselle, C. and Sanders, P.},
   article_number = {3},
   doi = {http://dx.doi.org/10.1007/s00204-022-03435-7},
   keywords = {Next-generation risk assessment (NGRA); Chemicals; Safety assessment; Exposure assessment; Hazard characterisation; Human biomonitoring (HBM); New approach methods (NAM)},
   language = {eng},
   issn = {0340-5761},
   journal = {Archives of Toxicology},
   title = {A walk in the PARC: developing and implementing 21st century chemical risk assessment in Europe},
   url = {https://link.springer.com/article/10.1007/s00204-022-03435-7},
   volume = {97},
   year = {2023}
}

TY  - JOUR
ID  - 2364798
AU  - Marx-Stoelting, P. - Riviere, G. - Luijten, M. - Aiello-Holden, K. - Bandow, N. - Baken, K. - Canas, A. - Castano, A. - Denys, S. - Fillol, C. - Herzler, M. - Iavicoli, I. - Karakitsios, S. - Klánová, Jana - Kolossa-Gehring, M. - Koutsodimou, A. - Vicente, J. Lobo - Lynch, I. - Namorado, S. - Norager, S. - Pittman, A. - Rotter, S. - Sarigiannis, D. - Silva, M. J. - Theunis, J. - Tralau, T. - Uhl, M. - van Klaveren, J. - Wendt-Rasch, L. - Westerholm, E. - Rousselle, C. - Sanders, P.
PY  - 2023
TI  - A walk in the PARC: developing and implementing 21st century chemical risk assessment in Europe
JF  - Archives of Toxicology
VL  - 97
IS  - 3
SP  - 893-908
EP  - 893-908
PB  - Springer
SN  - 03405761
KW  - Next-generation risk assessment (NGRA)
KW  - Chemicals
KW  - Safety assessment
KW  - Exposure assessment
KW  - Hazard characterisation
KW  - Human biomonitoring (HBM)
KW  - New approach methods (NAM)
UR  - https://link.springer.com/article/10.1007/s00204-022-03435-7
N2  - Current approaches for the assessment of environmental and human health risks due to exposure to chemical substances have served their purpose reasonably well. Nevertheless, the systems in place for different uses of chemicals are faced with various challenges, ranging from a growing number of chemicals to changes in the types of chemicals and materials produced. This has triggered global awareness of the need for a paradigm shift, which in turn has led to the publication of new concepts for chemical risk assessment and explorations of how to translate these concepts into pragmatic approaches. As a result, next-generation risk assessment (NGRA) is generally seen as the way forward. However, incorporating new scientific insights and innovative approaches into hazard and exposure assessments in such a way that regulatory needs are adequately met has appeared to be challenging. The European Partnership for the Assessment of Risks from Chemicals (PARC) has been designed to address various challenges associated with innovating chemical risk assessment. Its overall goal is to consolidate and strengthen the European research and innovation capacity for chemical risk assessment to protect human health and the environment. With around 200 participating organisations from all over Europe, including three European agencies, and a total budget of over 400 million euro, PARC is one of the largest projects of its kind. It has a duration of seven years and is coordinated by ANSES, the French Agency for Food, Environmental and Occupational Health and Safety.
ER  -

MARX-STOELTING, P., G. RIVIERE, M. LUIJTEN, K. AIELLO-HOLDEN, N. BANDOW, K. BAKEN, A. CANAS, A. CASTANO, S. DENYS, C. FILLOL, M. HERZLER, I. IAVICOLI, S. KARAKITSIOS, Jana KLÁNOVÁ, M. KOLOSSA-GEHRING, A. KOUTSODIMOU, J. Lobo VICENTE, I. LYNCH, S. NAMORADO, S. NORAGER, A. PITTMAN, S. ROTTER, D. SARIGIANNIS, M. J. SILVA, J. THEUNIS, T. TRALAU, M. UHL, J. VAN KLAVEREN, L. WENDT-RASCH, E. WESTERHOLM, C. ROUSSELLE and P. SANDERS. A walk in the PARC: developing and implementing 21st century chemical risk assessment in Europe. \textit{Archives of Toxicology}. Springer, 2023, vol.~97, No~3, p.~893-908. ISSN~0340-5761. Available from: https://dx.doi.org/10.1007/s00204-022-03435-7.

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