A Critical Review on the Opportunity to Use Placenta and Innovative Biomonitoring Methods to Characterize the Prenatal Chemical Exposome

CONTINI, Thomas Angelo Adrien, Remi BERANGER, Luc MULTIGNER, Jana KLÁNOVÁ, Elliott James PRICE and Arthur DAVID. A Critical Review on the Opportunity to Use Placenta and Innovative Biomonitoring Methods to Characterize the Prenatal Chemical Exposome. ENVIRONMENTAL SCIENCE & TECHNOLOGY. WASHINGTON: AMER CHEMICAL SOC, 2023, vol. 57, No 41, p. 15301-15313. ISSN 0013-936X. Available from: https://dx.doi.org/10.1021/acs.est.3c04845.

Basic information

• Original name: A Critical Review on the Opportunity to Use Placenta and Innovative Biomonitoring Methods to Characterize the Prenatal Chemical Exposome
• Authors: CONTINI, Thomas Angelo Adrien (250 France, belonging to the institution), Remi BERANGER, Luc MULTIGNER, Jana KLÁNOVÁ (203 Czech Republic, guarantor, belonging to the institution), Elliott James PRICE (826 United Kingdom of Great Britain and Northern Ireland, belonging to the institution) and Arthur DAVID.
• Edition: ENVIRONMENTAL SCIENCE & TECHNOLOGY, WASHINGTON, AMER CHEMICAL SOC, 2023, 0013-936X.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 10511 Environmental sciences
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 11.400 in 2022
• RIV identification code: RIV/00216224:14310/23:00133183
• Organization unit: Faculty of Science
• Doi: http://dx.doi.org/10.1021/acs.est.3c04845
• UT WoS: 001080892700001
• Keywords in English: placenta; prenatal; xenobiotics; high-resolutionmass spectrometry; chemical exposomics; metabolomics; suspect screening; nontargeted
• Tags: rivok
• Tags: International impact, Reviewed

Abstract

Adverse effects associated with chemical exposures during pregnancy include several developmental and reproductive disorders. However, considering the tens of thousands of chemicals present on the market, the effects of chemical mixtures on the developing fetus is still likely underestimated. In this critical review, we discuss the potential to apply innovative biomonitoring methods using high-resolution mass spectrometry (HRMS) on placenta to improve the monitoring of chemical exposure during pregnancy. The physiology of the placenta and its relevance as a matrix for monitoring chemical exposures and their effects on fetal health is first outlined. We then identify several key parameters that require further investigations before placenta can be used for large-scale monitoring in a robust manner. Most critical is the need for standardization of placental sampling. Placenta is a highly heterogeneous organ, and knowledge of the intraplacenta variability of chemical composition is required to ensure unbiased and robust interindividual comparisons. Other important variables include the time of collection, the sex of the fetus, and mode of delivery. Finally, we discuss the first applications of HRMS methods on the placenta to decipher the chemical exposome and describe how the use of placenta can complement biofluids collected on the mother or the fetus.

Links

• EF17_043/0009632, research and development project: Name: CETOCOEN Excellence
• LM2023069, research and development project: Name: Výzkumná infrastruktura RECETOX

Investor: Ministry of Education, Youth and Sports of the CR, RECETOX research infrastructure

• 857560, interní kód MU(CEP code: EF17_043/0009632): Name: CETOCOEN Excellence (Acronym: CETOCOEN Excellence)

Investor: European Union, Spreading excellence and widening participation