A Critical Review on the Opportunity to Use Placenta and
Innovative Biomonitoring Methods to Characterize the Prenatal
Chemical Exposome

J 2023

A Critical Review on the Opportunity to Use Placenta and Innovative Biomonitoring Methods to Characterize the Prenatal Chemical Exposome

CONTINI, Thomas Angelo Adrien, Remi BERANGER, Luc MULTIGNER, Jana KLÁNOVÁ, Elliott James PRICE et. al.

Basic information

Original name

A Critical Review on the Opportunity to Use Placenta and Innovative Biomonitoring Methods to Characterize the Prenatal Chemical Exposome

Authors

CONTINI, Thomas Angelo Adrien (250 France, belonging to the institution), Remi BERANGER, Luc MULTIGNER, Jana KLÁNOVÁ (203 Czech Republic, guarantor, belonging to the institution), Elliott James PRICE (826 United Kingdom of Great Britain and Northern Ireland, belonging to the institution) and Arthur DAVID

Edition

ENVIRONMENTAL SCIENCE & TECHNOLOGY, WASHINGTON, AMER CHEMICAL SOC, 2023, 0013-936X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10511 Environmental sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 11.400 in 2022

RIV identification code

RIV/00216224:14310/23:00133183

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1021/acs.est.3c04845

UT WoS

001080892700001

Keywords in English

placenta; prenatal; xenobiotics; high-resolutionmass spectrometry; chemical exposomics; metabolomics; suspect screening; nontargeted

Abstract

V originále

Adverse effects associated with chemical exposures during pregnancy include several developmental and reproductive disorders. However, considering the tens of thousands of chemicals present on the market, the effects of chemical mixtures on the developing fetus is still likely underestimated. In this critical review, we discuss the potential to apply innovative biomonitoring methods using high-resolution mass spectrometry (HRMS) on placenta to improve the monitoring of chemical exposure during pregnancy. The physiology of the placenta and its relevance as a matrix for monitoring chemical exposures and their effects on fetal health is first outlined. We then identify several key parameters that require further investigations before placenta can be used for large-scale monitoring in a robust manner. Most critical is the need for standardization of placental sampling. Placenta is a highly heterogeneous organ, and knowledge of the intraplacenta variability of chemical composition is required to ensure unbiased and robust interindividual comparisons. Other important variables include the time of collection, the sex of the fetus, and mode of delivery. Finally, we discuss the first applications of HRMS methods on the placenta to decipher the chemical exposome and describe how the use of placenta can complement biofluids collected on the mother or the fetus.

Links

EF17_043/0009632, research and development project

Name: CETOCOEN Excellence

LM2023069, research and development project

Name: Výzkumná infrastruktura RECETOX

Investor: Ministry of Education, Youth and Sports of the CR, RECETOX research infrastructure

857560, interní kód MU
(CEP code: EF17_043/0009632)

Name: CETOCOEN Excellence (Acronym: CETOCOEN Excellence)

Investor: European Union, Spreading excellence and widening participation

Citovat

CONTINI, Thomas Angelo Adrien, Remi BERANGER, Luc MULTIGNER, Jana KLÁNOVÁ, Elliott James PRICE and Arthur DAVID. A Critical Review on the Opportunity to Use Placenta and Innovative Biomonitoring Methods to Characterize the Prenatal Chemical Exposome. ENVIRONMENTAL SCIENCE & TECHNOLOGY. WASHINGTON: AMER CHEMICAL SOC, 2023, vol. 57, No 41, p. 15301-15313. ISSN 0013-936X. Available from: https://dx.doi.org/10.1021/acs.est.3c04845.

@article{2364939,
   author = {Contini, Thomas Angelo Adrien and Beranger, Remi and Multigner, Luc and Klánová, Jana and Price, Elliott James and David, Arthur},
   article_location = {WASHINGTON},
   article_number = {41},
   doi = {http://dx.doi.org/10.1021/acs.est.3c04845},
   keywords = {placenta; prenatal; xenobiotics; high-resolutionmass spectrometry; chemical exposomics; metabolomics; suspect screening; nontargeted},
   language = {eng},
   issn = {0013-936X},
   journal = {ENVIRONMENTAL SCIENCE & TECHNOLOGY},
   title = {A Critical Review on the Opportunity to Use Placenta and Innovative Biomonitoring Methods to Characterize the Prenatal Chemical Exposome},
   url = {https://pubs.acs.org/doi/10.1021/acs.est.3c04845},
   volume = {57},
   year = {2023}
}

TY  - JOUR
ID  - 2364939
AU  - Contini, Thomas Angelo Adrien - Beranger, Remi - Multigner, Luc - Klánová, Jana - Price, Elliott James - David, Arthur
PY  - 2023
TI  - A Critical Review on the Opportunity to Use Placenta and Innovative Biomonitoring Methods to Characterize the Prenatal Chemical Exposome
JF  - ENVIRONMENTAL SCIENCE & TECHNOLOGY
VL  - 57
IS  - 41
SP  - 15301-15313
EP  - 15301-15313
PB  - AMER CHEMICAL SOC
SN  - 0013936X
KW  - placenta
KW  - prenatal
KW  - xenobiotics
KW  - high-resolutionmass spectrometry
KW  - chemical exposomics
KW  - metabolomics
KW  - suspect screening
KW  - nontargeted
UR  - https://pubs.acs.org/doi/10.1021/acs.est.3c04845
N2  - Adverse effects associated with chemical exposures during pregnancy include several developmental and reproductive disorders. However, considering the tens of thousands of chemicals present on the market, the effects of chemical mixtures on the developing fetus is still likely underestimated. In this critical review, we discuss the potential to apply innovative biomonitoring methods using high-resolution mass spectrometry (HRMS) on placenta to improve the monitoring of chemical exposure during pregnancy. The physiology of the placenta and its relevance as a matrix for monitoring chemical exposures and their effects on fetal health is first outlined. We then identify several key parameters that require further investigations before placenta can be used for large-scale monitoring in a robust manner. Most critical is the need for standardization of placental sampling. Placenta is a highly heterogeneous organ, and knowledge of the intraplacenta variability of chemical composition is required to ensure unbiased and robust interindividual comparisons. Other important variables include the time of collection, the sex of the fetus, and mode of delivery. Finally, we discuss the first applications of HRMS methods on the placenta to decipher the chemical exposome and describe how the use of placenta can complement biofluids collected on the mother or the fetus.
ER  -

CONTINI, Thomas Angelo Adrien, Remi BERANGER, Luc MULTIGNER, Jana KLÁNOVÁ, Elliott James PRICE and Arthur DAVID. A Critical Review on the Opportunity to Use Placenta and Innovative Biomonitoring Methods to Characterize the Prenatal Chemical Exposome. \textit{ENVIRONMENTAL SCIENCE \&{}amp; TECHNOLOGY}. WASHINGTON: AMER CHEMICAL SOC, 2023, vol.~57, No~41, p.~15301-15313. ISSN~0013-936X. Available from: https://dx.doi.org/10.1021/acs.est.3c04845.

Detailed Information on Publication Record