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@article{2365478, author = {Boekema, Bouke K H L and Chrysostomou, Daniela and Ciprandi, Guido and Elgersma, Anouk and Vlig, Marcel and Pokorná, Andrea and Peters, Linsey J F and Cremers, Niels A J}, article_location = {OXFORD}, article_number = {3}, doi = {http://dx.doi.org/10.1016/j.burns.2023.10.009}, keywords = {Medical-grade honey; Pseudomonas aeruginosa; Silver sulphadiazine; Silver nitrate; Infected burn wounds; Wound healing}, language = {eng}, issn = {0305-4179}, journal = {Burns}, title = {Comparing the antibacterial and healing properties of medical-grade honey and silver-based wound care products in burns}, url = {https://www.sciencedirect.com/science/article/pii/S0305417923002115?via%3Dihub}, volume = {50}, year = {2024} }
TY - JOUR ID - 2365478 AU - Boekema, Bouke K H L - Chrysostomou, Daniela - Ciprandi, Guido - Elgersma, Anouk - Vlig, Marcel - Pokorná, Andrea - Peters, Linsey J F - Cremers, Niels A J PY - 2024 TI - Comparing the antibacterial and healing properties of medical-grade honey and silver-based wound care products in burns JF - Burns VL - 50 IS - 3 SP - 597-610 EP - 597-610 PB - ELSEVIER SN - 03054179 KW - Medical-grade honey KW - Pseudomonas aeruginosa KW - Silver sulphadiazine KW - Silver nitrate KW - Infected burn wounds KW - Wound healing UR - https://www.sciencedirect.com/science/article/pii/S0305417923002115?via%3Dihub N2 - Burns are a major global healthcare concern, often complicated by the presence of bacteria such as Pseudomonas aeruginosa in the wounds. Silver-based dressings are commonly used in the treatment of burns but can cause skin irritation and delay healing time. Medical-grade honey (MGH) provides an interesting alternative. This study investigated the antimicrobial effects and possible cytotoxicity of L-Mesitran Soft (MGH-gel) and its individual components, Medihoney (Manuka), Flammazine (silver sulphadiazine), and silver nitrate (AgNO3) in an ex vivo human burn wound model. Bacterial survival and wound healing parameters, including re-epithelialization and keratinocyte proliferation were assessed. L-Mesitran, Flammazine, and AgNO3 reduced P. aeruginosa numbers below detection levels. L-Mesitran Soft exhibited a significantly stronger antimicrobial effect compared to Medihoney. The individual components of L-Mesitran contributed significantly to its antibacterial efficacy, thus suggesting synergistic activities. Moreover, L-Mesitran, Flammazine, and AgNO3 slightly inhibited re-epithelialization while Medihoney treatment resulted in a complete lack of re-epithelialization and keratinocyte proliferation. Furthermore, clinical cases illustrated the effectiveness of MGH therapy in infected burns. Overall, L-Mesitran Soft had similar effects as silver-based products on bacterial load and epidermal regeneration, but outperformed Medihoney. Therefore, supplemented MGH could be used as an effective alternative to silver-based dressings for P. aeruginosa-infected burns. ER -
BOEKEMA, Bouke K H L, Daniela CHRYSOSTOMOU, Guido CIPRANDI, Anouk ELGERSMA, Marcel VLIG, Andrea POKORNÁ, Linsey J F PETERS and Niels A J CREMERS. Comparing the antibacterial and healing properties of medical-grade honey and silver-based wound care products in burns. \textit{Burns}. OXFORD: ELSEVIER, 2024, vol.~50, No~3, p.~597-610. ISSN~0305-4179. Available from: https://dx.doi.org/10.1016/j.burns.2023.10.009.
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