Comparing the antibacterial and healing properties of
medical-grade honey and silver-based wound care products in
burns

J 2024

Comparing the antibacterial and healing properties of medical-grade honey and silver-based wound care products in burns

BOEKEMA, Bouke K H L, Daniela CHRYSOSTOMOU, Guido CIPRANDI, Anouk ELGERSMA, Marcel VLIG et. al.

Basic information

Original name

Comparing the antibacterial and healing properties of medical-grade honey and silver-based wound care products in burns

Authors

BOEKEMA, Bouke K H L, Daniela CHRYSOSTOMOU (710 South Africa, belonging to the institution), Guido CIPRANDI, Anouk ELGERSMA, Marcel VLIG, Andrea POKORNÁ (203 Czech Republic, belonging to the institution), Linsey J F PETERS and Niels A J CREMERS

Edition

Burns, OXFORD, ELSEVIER, 2024, 0305-4179

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30216 Dermatology and venereal diseases

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.700 in 2022

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.burns.2023.10.009

UT WoS

001218241200001

Keywords in English

Medical-grade honey; Pseudomonas aeruginosa; Silver sulphadiazine; Silver nitrate; Infected burn wounds; Wound healing

Abstract

V originále

Burns are a major global healthcare concern, often complicated by the presence of bacteria such as Pseudomonas aeruginosa in the wounds. Silver-based dressings are commonly used in the treatment of burns but can cause skin irritation and delay healing time. Medical-grade honey (MGH) provides an interesting alternative. This study investigated the antimicrobial effects and possible cytotoxicity of L-Mesitran Soft (MGH-gel) and its individual components, Medihoney (Manuka), Flammazine (silver sulphadiazine), and silver nitrate (AgNO3) in an ex vivo human burn wound model. Bacterial survival and wound healing parameters, including re-epithelialization and keratinocyte proliferation were assessed. L-Mesitran, Flammazine, and AgNO3 reduced P. aeruginosa numbers below detection levels. L-Mesitran Soft exhibited a significantly stronger antimicrobial effect compared to Medihoney. The individual components of L-Mesitran contributed significantly to its antibacterial efficacy, thus suggesting synergistic activities. Moreover, L-Mesitran, Flammazine, and AgNO3 slightly inhibited re-epithelialization while Medihoney treatment resulted in a complete lack of re-epithelialization and keratinocyte proliferation. Furthermore, clinical cases illustrated the effectiveness of MGH therapy in infected burns. Overall, L-Mesitran Soft had similar effects as silver-based products on bacterial load and epidermal regeneration, but outperformed Medihoney. Therefore, supplemented MGH could be used as an effective alternative to silver-based dressings for P. aeruginosa-infected burns.

Citovat

BOEKEMA, Bouke K H L, Daniela CHRYSOSTOMOU, Guido CIPRANDI, Anouk ELGERSMA, Marcel VLIG, Andrea POKORNÁ, Linsey J F PETERS and Niels A J CREMERS. Comparing the antibacterial and healing properties of medical-grade honey and silver-based wound care products in burns. Burns. OXFORD: ELSEVIER, 2024, vol. 50, No 3, p. 597-610. ISSN 0305-4179. Available from: https://dx.doi.org/10.1016/j.burns.2023.10.009.

@article{2365478,
   author = {Boekema, Bouke K H L and Chrysostomou, Daniela and Ciprandi, Guido and Elgersma, Anouk and Vlig, Marcel and Pokorná, Andrea and Peters, Linsey J F and Cremers, Niels A J},
   article_location = {OXFORD},
   article_number = {3},
   doi = {http://dx.doi.org/10.1016/j.burns.2023.10.009},
   keywords = {Medical-grade honey; Pseudomonas aeruginosa; Silver sulphadiazine; Silver nitrate; Infected burn wounds; Wound healing},
   language = {eng},
   issn = {0305-4179},
   journal = {Burns},
   title = {Comparing the antibacterial and healing properties of medical-grade honey and silver-based wound care products in burns},
   url = {https://www.sciencedirect.com/science/article/pii/S0305417923002115?via%3Dihub},
   volume = {50},
   year = {2024}
}

TY  - JOUR
ID  - 2365478
AU  - Boekema, Bouke K H L - Chrysostomou, Daniela - Ciprandi, Guido - Elgersma, Anouk - Vlig, Marcel - Pokorná, Andrea - Peters, Linsey J F - Cremers, Niels A J
PY  - 2024
TI  - Comparing the antibacterial and healing properties of medical-grade honey and silver-based wound care products in burns
JF  - Burns
VL  - 50
IS  - 3
SP  - 597-610
EP  - 597-610
PB  - ELSEVIER
SN  - 03054179
KW  - Medical-grade honey
KW  - Pseudomonas aeruginosa
KW  - Silver sulphadiazine
KW  - Silver nitrate
KW  - Infected burn wounds
KW  - Wound healing
UR  - https://www.sciencedirect.com/science/article/pii/S0305417923002115?via%3Dihub
N2  - Burns are a major global healthcare concern, often complicated by the presence of bacteria such as Pseudomonas aeruginosa in the wounds. Silver-based dressings are commonly used in the treatment of burns but can cause skin irritation and delay healing time. Medical-grade honey (MGH) provides an interesting alternative. This study investigated the antimicrobial effects and possible cytotoxicity of L-Mesitran Soft (MGH-gel) and its individual components, Medihoney (Manuka), Flammazine (silver sulphadiazine), and silver nitrate (AgNO3) in an ex vivo human burn wound model. Bacterial survival and wound healing parameters, including re-epithelialization and keratinocyte proliferation were assessed. L-Mesitran, Flammazine, and AgNO3 reduced P. aeruginosa numbers below detection levels. L-Mesitran Soft exhibited a significantly stronger antimicrobial effect compared to Medihoney. The individual components of L-Mesitran contributed significantly to its antibacterial efficacy, thus suggesting synergistic activities. Moreover, L-Mesitran, Flammazine, and AgNO3 slightly inhibited re-epithelialization while Medihoney treatment resulted in a complete lack of re-epithelialization and keratinocyte proliferation. Furthermore, clinical cases illustrated the effectiveness of MGH therapy in infected burns. Overall, L-Mesitran Soft had similar effects as silver-based products on bacterial load and epidermal regeneration, but outperformed Medihoney. Therefore, supplemented MGH could be used as an effective alternative to silver-based dressings for P. aeruginosa-infected burns.
ER  -

BOEKEMA, Bouke K H L, Daniela CHRYSOSTOMOU, Guido CIPRANDI, Anouk ELGERSMA, Marcel VLIG, Andrea POKORNÁ, Linsey J F PETERS and Niels A J CREMERS. Comparing the antibacterial and healing properties of medical-grade honey and silver-based wound care products in burns. \textit{Burns}. OXFORD: ELSEVIER, 2024, vol.~50, No~3, p.~597-610. ISSN~0305-4179. Available from: https://dx.doi.org/10.1016/j.burns.2023.10.009.

Detailed Information on Publication Record