Other malignancies in the history of CLL: an international multicenter study conducted by ERIC, the European Research Initiative on CLL, in HARMONY
Authors
CHATZIKONSTANTINOU, Thomas, Lydia SCARFÒ, Georgios KARAKATSOULIS, Eva MINGA, Dimitra CHAMOU, Gloria IACOBONI, Jana KOTAŠKOVÁ (203 Czech Republic, belonging to the institution), Christos DEMOSTHENOUS, Lukas SMOLEJ, Stephen MULLIGAN, Miguel ALCOCEBA, Salem AL-SHEMARI, Thérèse AURRAN-SCHLEINITZ, Francesca BACCHIARRI, Mar BELLIDO, Fontanet BIJOU, Anne CALLEJA, Angeles MEDINA, Mehreen Ali KHAN, Ramona CASSIN, Sofia CHATZILEONTIADOU, Rosa COLLADO, Amy CHRISTIAN, Zadie DAVIS, Maria DIMOU, David DONALDSON, Gimena Dos SANTOS, Barbara DRETA, Maria EFSTATHOPOULOU, Shaimaa EL-ASHWAH, Alicia ENRICO, Alberto FRESA, Sara GALIMBERTI, Andrea GALITZIA, Rocío GARCÍA-SERRA, Eva GIMENO, Isabel GONZÁLEZ-GASCÓN-Y-MARÍN, Alessandro GOZZETTI, Valerio GUARENTE, Romain GUIEZE, Ajay GOGIA, Ritu GUPTA, Sean HARROP, Eleftheria HATZIMICHAEL, Yair HERISHANU, Hernández-Rivas JOSÉ-ÁNGEL, Luca INCHIAPPA, Ozren JAKSIC, Susanne JANSSEN, Elżbieta KALICIŃSKA, Laribi KAMEL, Volkan KARAKUS, Arnon P KATER, Bonnie KHO, Maria KISLOVA, Eliana KONSTANTINOU, Maya KOREN-MICHOWITZ, Ioannis KOTSIANIDIS, Robert J KREITMAN, Jorge LABRADOR, Deepesh LAD, Levin MARK-DAVID, Ilana LEVY, Thomas LONGVAL, Alberto LOPEZ-GARCIA, Juan MARQUET, Lucia MARTIN-RODRÍGUEZ, Marc MAYNADIÉ, Stanislava MASLEJOVA, Carlota MAYOR-BASTIDA, Biljana MIHALJEVIC, Ivana MILOSEVIC, Fatima MIRAS, Riccardo MOIA, Marta MORAWSKA, Roberta MURRU, Uttam Kumar NATH, Almudena NAVARRO-BAILÓN, Ana C OLIVEIRA, Jacopo OLIVIERI, David OSCIER, Irina PANOVSKA-STAVRIDIS, Maria PAPAIOANNOU, Tomas PAPAJÍK, Zuzana KUBOVA, Punyarat PHUMPHUKHIEO, Cheyenne PIERIE, Anna PUIGGROS, Lata RANI, Gianluigi REDA, Gian Matteo RIGOLIN, Rosa RUCHLEMER, Marcos Daniel de Deus SANTOS, Mattia SCHIPANI, Annett SCHIWITZA, Yandong SHEN, Martin SIMKOVIC, Svetlana SMIRNOVA, Dina Sameh Abdelrahman SOLIMAN, Martin SPACEK, Tamar TADMOR, Kristina TOMIC, Eric TSE, Theodoros VASSILAKOPOULOS, Andrea VISENTIN, Candida VITALE, Julia von TRESCKOW, George VRACHIOLIAS, Vojin VUKOVIC, Renata WALEWSKA, Ewa WASIK-SZCZEPANEK, Zhenshu XU, Munci YAGCI, Lucrecia YAÑEZ, Mohamed YASSIN, Jana ZUCHNICKA, Maria ANGELOPOULOU, Darko ANTIC, Bella BIDERMAN, Mark CATHERWOOD, Rainer CLAUS, Marta COSCIA, Antonio CUNEO, Fatih DEMIRKAN, Blanca ESPINET, Gianluca GAIDANO, Olga B KALASHNIKOVA, Luca LAURENTI, Eugene NIKITIN, Gerassimos A PANGALIS, Panagiotis PANAGIOTIDIS, Viola Maria POPOV, Sarka POSPISILOVA, Paolo SPORTOLETTI, Niki STAVROYIANNI, Constantine TAM, Livio TRENTIN, Anastasia CHATZIDIMITRIOU, Francesc BOSCH, Michael DOUBEK, Paolo GHIA and Kostas STAMATOPOULOS
Background Patients with chronic lymphocytic leukemia (CLL) have a higher risk of developing other malignancies (OMs) compared to the general population. However, the impact of CLL-related risk factors and CLL-directed treatment is still unclear and represents the focus of this work. Methods We conducted a retrospective international multicenter study to assess the incidence of OMs and detect potential risk factors in 19,705 patients with CLL, small lymphocytic lymphoma, or high-count CLL-like monoclonal B-cell lymphocytosis, diagnosed between 2000 and 2016. Data collection took place between October 2020 and March 2022. Findings In 129,254 years of follow-up after CLL diagnosis, 3513 OMs were diagnosed (27.2 OMs/1000 person-years). The most common hematological OMs were Richter transformation, myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Non-melanoma skin (NMSC) and prostate cancers were the most common solid tumors (STs). The only predictor for MDS and AML development was treatment with fludarabine and cyclophosphamide with/without rituximab (FC ± R) (OR = 3.7; 95% CI = 2.79–4.91; p < 0.001). STs were more frequent in males and patients with unmutated immunoglobulin heavy variable genes (OR = 1.77; 95% CI = 1.49–2.11; p < 0.001/OR = 1.89; 95% CI = 1.6–2.24; p < 0.001). CLL-directed treatment was associated with non-melanoma skin and prostate cancers (OR = 1.8; 95% CI = 1.36–2.41; p < 0.001/OR = 2.11; 95% CI = 1.12–3.97; p = 0.021). In contrast, breast cancers were more frequent in untreated patients (OR = 0.17; 95% CI = 0.08–0.33; p < 0.001). Patients with CLL and an OM had inferior overall survival (OS) than those without. AML and MDS conferred the worst OS (p < 0.001). Interpretation OMs in CLL impact on OS. Treatment for CLL increased the risk for AML/MDS, prostate cancer, and NMSC. FCR was associated with increased risk for AML/MDS.
Links
LX22NPO5102, research and development project
Name: Národní ústav pro výzkum rakoviny (Acronym: NÚVR)
Investor: Ministry of Education, Youth and Sports of the CR, National institute for cancer research, 5.1 EXCELES
CHATZIKONSTANTINOU, Thomas, Lydia SCARFÒ, Georgios KARAKATSOULIS, Eva MINGA, Dimitra CHAMOU, Gloria IACOBONI, Jana KOTAŠKOVÁ, Christos DEMOSTHENOUS, Lukas SMOLEJ, Stephen MULLIGAN, Miguel ALCOCEBA, Salem AL-SHEMARI, Thérèse AURRAN-SCHLEINITZ, Francesca BACCHIARRI, Mar BELLIDO, Fontanet BIJOU, Anne CALLEJA, Angeles MEDINA, Mehreen Ali KHAN, Ramona CASSIN, Sofia CHATZILEONTIADOU, Rosa COLLADO, Amy CHRISTIAN, Zadie DAVIS, Maria DIMOU, David DONALDSON, Gimena Dos SANTOS, Barbara DRETA, Maria EFSTATHOPOULOU, Shaimaa EL-ASHWAH, Alicia ENRICO, Alberto FRESA, Sara GALIMBERTI, Andrea GALITZIA, Rocío GARCÍA-SERRA, Eva GIMENO, Isabel GONZÁLEZ-GASCÓN-Y-MARÍN, Alessandro GOZZETTI, Valerio GUARENTE, Romain GUIEZE, Ajay GOGIA, Ritu GUPTA, Sean HARROP, Eleftheria HATZIMICHAEL, Yair HERISHANU, Hernández-Rivas JOSÉ-ÁNGEL, Luca INCHIAPPA, Ozren JAKSIC, Susanne JANSSEN, Elżbieta KALICIŃSKA, Laribi KAMEL, Volkan KARAKUS, Arnon P KATER, Bonnie KHO, Maria KISLOVA, Eliana KONSTANTINOU, Maya KOREN-MICHOWITZ, Ioannis KOTSIANIDIS, Robert J KREITMAN, Jorge LABRADOR, Deepesh LAD, Levin MARK-DAVID, Ilana LEVY, Thomas LONGVAL, Alberto LOPEZ-GARCIA, Juan MARQUET, Lucia MARTIN-RODRÍGUEZ, Marc MAYNADIÉ, Stanislava MASLEJOVA, Carlota MAYOR-BASTIDA, Biljana MIHALJEVIC, Ivana MILOSEVIC, Fatima MIRAS, Riccardo MOIA, Marta MORAWSKA, Roberta MURRU, Uttam Kumar NATH, Almudena NAVARRO-BAILÓN, Ana C OLIVEIRA, Jacopo OLIVIERI, David OSCIER, Irina PANOVSKA-STAVRIDIS, Maria PAPAIOANNOU, Tomas PAPAJÍK, Zuzana KUBOVA, Punyarat PHUMPHUKHIEO, Cheyenne PIERIE, Anna PUIGGROS, Lata RANI, Gianluigi REDA, Gian Matteo RIGOLIN, Rosa RUCHLEMER, Marcos Daniel de Deus SANTOS, Mattia SCHIPANI, Annett SCHIWITZA, Yandong SHEN, Martin SIMKOVIC, Svetlana SMIRNOVA, Dina Sameh Abdelrahman SOLIMAN, Martin SPACEK, Tamar TADMOR, Kristina TOMIC, Eric TSE, Theodoros VASSILAKOPOULOS, Andrea VISENTIN, Candida VITALE, Julia von TRESCKOW, George VRACHIOLIAS, Vojin VUKOVIC, Renata WALEWSKA, Ewa WASIK-SZCZEPANEK, Zhenshu XU, Munci YAGCI, Lucrecia YAÑEZ, Mohamed YASSIN, Jana ZUCHNICKA, Maria ANGELOPOULOU, Darko ANTIC, Bella BIDERMAN, Mark CATHERWOOD, Rainer CLAUS, Marta COSCIA, Antonio CUNEO, Fatih DEMIRKAN, Blanca ESPINET, Gianluca GAIDANO, Olga B KALASHNIKOVA, Luca LAURENTI, Eugene NIKITIN, Gerassimos A PANGALIS, Panagiotis PANAGIOTIDIS, Viola Maria POPOV, Sarka POSPISILOVA, Paolo SPORTOLETTI, Niki STAVROYIANNI, Constantine TAM, Livio TRENTIN, Anastasia CHATZIDIMITRIOU, Francesc BOSCH, Michael DOUBEK, Paolo GHIA and Kostas STAMATOPOULOS. Other malignancies in the history of CLL: an international multicenter study conducted by ERIC, the European Research Initiative on CLL, in HARMONY. EClinicalMedicine. AMSTERDAM: ELSEVIER, 2023, vol. 65, November 2023, p. 1-14. ISSN 2589-5370. Available from: https://dx.doi.org/10.1016/j.eclinm.2023.102307.
@article{2365503, author = {Chatzikonstantinou, Thomas and Scarfò, Lydia and Karakatsoulis, Georgios and Minga, Eva and Chamou, Dimitra and Iacoboni, Gloria and Kotašková, Jana and Demosthenous, Christos and Smolej, Lukas and Mulligan, Stephen and Alcoceba, Miguel and AlandShemari, Salem and AurranandSchleinitz, Thérèse and Bacchiarri, Francesca and Bellido, Mar and Bijou, Fontanet and Calleja, Anne and Medina, Angeles and Khan, Mehreen Ali and Cassin, Ramona and Chatzileontiadou, Sofia and Collado, Rosa and Christian, Amy and Davis, Zadie and Dimou, Maria and Donaldson, David and Santos, Gimena Dos and Dreta, Barbara and Efstathopoulou, Maria and ElandAshwah, Shaimaa and Enrico, Alicia and Fresa, Alberto and Galimberti, Sara and Galitzia, Andrea and GarcíaandSerra, Rocío and Gimeno, Eva and GonzálezandGascónandYandMarín, Isabel and Gozzetti, Alessandro and Guarente, Valerio and Guieze, Romain and Gogia, Ajay and Gupta, Ritu and Harrop, Sean and Hatzimichael, Eleftheria and Herishanu, Yair and JoséandÁngel, HernándezandRivas and Inchiappa, Luca and Jaksic, Ozren and Janssen, Susanne and Kalicińska, Elżbieta and Kamel, Laribi and Karakus, Volkan and Kater, Arnon P and Kho, Bonnie and Kislova, Maria and Konstantinou, Eliana and KorenandMichowitz, Maya and Kotsianidis, Ioannis and Kreitman, Robert J and Labrador, Jorge and Lad, Deepesh and MarkandDavid, Levin and Levy, Ilana and Longval, Thomas and LopezandGarcia, Alberto and Marquet, Juan and MartinandRodríguez, Lucia and Maynadié, Marc and Maslejova, Stanislava and MayorandBastida, Carlota and Mihaljevic, Biljana and Milosevic, Ivana and Miras, Fatima and Moia, Riccardo and Morawska, Marta and Murru, Roberta and Nath, Uttam Kumar and NavarroandBailón, Almudena and Oliveira, Ana C and Olivieri, Jacopo and Oscier, David and PanovskaandStavridis, Irina and Papaioannou, Maria and Papajík, Tomas and Kubova, Zuzana and Phumphukhieo, Punyarat and Pierie, Cheyenne and Puiggros, Anna and Rani, Lata and Reda, Gianluigi and Rigolin, Gian Matteo and Ruchlemer, Rosa and Santos, Marcos Daniel de Deus and Schipani, Mattia and Schiwitza, Annett and Shen, Yandong and Simkovic, Martin and Smirnova, Svetlana and Soliman, Dina Sameh Abdelrahman and Spacek, Martin and Tadmor, Tamar and Tomic, Kristina and Tse, Eric and Vassilakopoulos, Theodoros and Visentin, Andrea and Vitale, Candida and Tresckow, Julia von and Vrachiolias, George and Vukovic, Vojin and Walewska, Renata and WasikandSzczepanek, Ewa and Xu, Zhenshu and Yagci, Munci and Yañez, Lucrecia and Yassin, Mohamed and Zuchnicka, Jana and Angelopoulou, Maria and Antic, Darko and Biderman, Bella and Catherwood, Mark and Claus, Rainer and Coscia, Marta and Cuneo, Antonio and Demirkan, Fatih and Espinet, Blanca and Gaidano, Gianluca and Kalashnikova, Olga B and Laurenti, Luca and Nikitin, Eugene and Pangalis, Gerassimos A and Panagiotidis, Panagiotis and Popov, Viola Maria and Pospisilova, Sarka and Sportoletti, Paolo and Stavroyianni, Niki and Tam, Constantine and Trentin, Livio and Chatzidimitriou, Anastasia and Bosch, Francesc and Doubek, Michael and Ghia, Paolo and Stamatopoulos, Kostas}, article_location = {AMSTERDAM}, article_number = {November 2023}, doi = {http://dx.doi.org/10.1016/j.eclinm.2023.102307}, keywords = {Chronic lymphocytic leukemia; Other malignancies; Other cancers; Second primary malignancies}, language = {eng}, issn = {2589-5370}, journal = {EClinicalMedicine}, title = {Other malignancies in the history of CLL: an international multicenter study conducted by ERIC, the European Research Initiative on CLL, in HARMONY}, url = {https://www.sciencedirect.com/science/article/pii/S2589537023004844?via%3Dihub}, volume = {65}, year = {2023} }
TY - JOUR ID - 2365503 AU - Chatzikonstantinou, Thomas - Scarfò, Lydia - Karakatsoulis, Georgios - Minga, Eva - Chamou, Dimitra - Iacoboni, Gloria - Kotašková, Jana - Demosthenous, Christos - Smolej, Lukas - Mulligan, Stephen - Alcoceba, Miguel - Al-Shemari, Salem - Aurran-Schleinitz, Thérèse - Bacchiarri, Francesca - Bellido, Mar - Bijou, Fontanet - Calleja, Anne - Medina, Angeles - Khan, Mehreen Ali - Cassin, Ramona - Chatzileontiadou, Sofia - Collado, Rosa - Christian, Amy - Davis, Zadie - Dimou, Maria - Donaldson, David - Santos, Gimena Dos - Dreta, Barbara - Efstathopoulou, Maria - El-Ashwah, Shaimaa - Enrico, Alicia - Fresa, Alberto - Galimberti, Sara - Galitzia, Andrea - García-Serra, Rocío - Gimeno, Eva - González-Gascón-Y-Marín, Isabel - Gozzetti, Alessandro - Guarente, Valerio - Guieze, Romain - Gogia, Ajay - Gupta, Ritu - Harrop, Sean - Hatzimichael, Eleftheria - Herishanu, Yair - José-Ángel, Hernández-Rivas - Inchiappa, Luca - Jaksic, Ozren - Janssen, Susanne - Kalicińska, Elżbieta - Kamel, Laribi - Karakus, Volkan - Kater, Arnon P - Kho, Bonnie - Kislova, Maria - Konstantinou, Eliana - Koren-Michowitz, Maya - Kotsianidis, Ioannis - Kreitman, Robert J - Labrador, Jorge - Lad, Deepesh - Mark-David, Levin - Levy, Ilana - Longval, Thomas - Lopez-Garcia, Alberto - Marquet, Juan - Martin-Rodríguez, Lucia - Maynadié, Marc - Maslejova, Stanislava - Mayor-Bastida, Carlota - Mihaljevic, Biljana - Milosevic, Ivana - Miras, Fatima - Moia, Riccardo - Morawska, Marta - Murru, Roberta - Nath, Uttam Kumar - Navarro-Bailón, Almudena - Oliveira, Ana C - Olivieri, Jacopo - Oscier, David - Panovska-Stavridis, Irina - Papaioannou, Maria - Papajík, Tomas - Kubova, Zuzana - Phumphukhieo, Punyarat - Pierie, Cheyenne - Puiggros, Anna - Rani, Lata - Reda, Gianluigi - Rigolin, Gian Matteo - Ruchlemer, Rosa - Santos, Marcos Daniel de Deus - Schipani, Mattia - Schiwitza, Annett - Shen, Yandong - Simkovic, Martin - Smirnova, Svetlana - Soliman, Dina Sameh Abdelrahman - Spacek, Martin - Tadmor, Tamar - Tomic, Kristina - Tse, Eric - Vassilakopoulos, Theodoros - Visentin, Andrea - Vitale, Candida - Tresckow, Julia von - Vrachiolias, George - Vukovic, Vojin - Walewska, Renata - Wasik-Szczepanek, Ewa - Xu, Zhenshu - Yagci, Munci - Yañez, Lucrecia - Yassin, Mohamed - Zuchnicka, Jana - Angelopoulou, Maria - Antic, Darko - Biderman, Bella - Catherwood, Mark - Claus, Rainer - Coscia, Marta - Cuneo, Antonio - Demirkan, Fatih - Espinet, Blanca - Gaidano, Gianluca - Kalashnikova, Olga B - Laurenti, Luca - Nikitin, Eugene - Pangalis, Gerassimos A - Panagiotidis, Panagiotis - Popov, Viola Maria - Pospisilova, Sarka - Sportoletti, Paolo - Stavroyianni, Niki - Tam, Constantine - Trentin, Livio - Chatzidimitriou, Anastasia - Bosch, Francesc - Doubek, Michael - Ghia, Paolo - Stamatopoulos, Kostas PY - 2023 TI - Other malignancies in the history of CLL: an international multicenter study conducted by ERIC, the European Research Initiative on CLL, in HARMONY JF - EClinicalMedicine VL - 65 IS - November 2023 SP - 1-14 EP - 1-14 PB - ELSEVIER SN - 25895370 KW - Chronic lymphocytic leukemia KW - Other malignancies KW - Other cancers KW - Second primary malignancies UR - https://www.sciencedirect.com/science/article/pii/S2589537023004844?via%3Dihub N2 - Background Patients with chronic lymphocytic leukemia (CLL) have a higher risk of developing other malignancies (OMs) compared to the general population. However, the impact of CLL-related risk factors and CLL-directed treatment is still unclear and represents the focus of this work. Methods We conducted a retrospective international multicenter study to assess the incidence of OMs and detect potential risk factors in 19,705 patients with CLL, small lymphocytic lymphoma, or high-count CLL-like monoclonal B-cell lymphocytosis, diagnosed between 2000 and 2016. Data collection took place between October 2020 and March 2022. Findings In 129,254 years of follow-up after CLL diagnosis, 3513 OMs were diagnosed (27.2 OMs/1000 person-years). The most common hematological OMs were Richter transformation, myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Non-melanoma skin (NMSC) and prostate cancers were the most common solid tumors (STs). The only predictor for MDS and AML development was treatment with fludarabine and cyclophosphamide with/without rituximab (FC ± R) (OR = 3.7; 95% CI = 2.79–4.91; p < 0.001). STs were more frequent in males and patients with unmutated immunoglobulin heavy variable genes (OR = 1.77; 95% CI = 1.49–2.11; p < 0.001/OR = 1.89; 95% CI = 1.6–2.24; p < 0.001). CLL-directed treatment was associated with non-melanoma skin and prostate cancers (OR = 1.8; 95% CI = 1.36–2.41; p < 0.001/OR = 2.11; 95% CI = 1.12–3.97; p = 0.021). In contrast, breast cancers were more frequent in untreated patients (OR = 0.17; 95% CI = 0.08–0.33; p < 0.001). Patients with CLL and an OM had inferior overall survival (OS) than those without. AML and MDS conferred the worst OS (p < 0.001). Interpretation OMs in CLL impact on OS. Treatment for CLL increased the risk for AML/MDS, prostate cancer, and NMSC. FCR was associated with increased risk for AML/MDS. ER -
CHATZIKONSTANTINOU, Thomas, Lydia SCARFÒ, Georgios KARAKATSOULIS, Eva MINGA, Dimitra CHAMOU, Gloria IACOBONI, Jana KOTAŠKOVÁ, Christos DEMOSTHENOUS, Lukas SMOLEJ, Stephen MULLIGAN, Miguel ALCOCEBA, Salem AL-SHEMARI, Thérèse AURRAN-SCHLEINITZ, Francesca BACCHIARRI, Mar BELLIDO, Fontanet BIJOU, Anne CALLEJA, Angeles MEDINA, Mehreen Ali KHAN, Ramona CASSIN, Sofia CHATZILEONTIADOU, Rosa COLLADO, Amy CHRISTIAN, Zadie DAVIS, Maria DIMOU, David DONALDSON, Gimena Dos SANTOS, Barbara DRETA, Maria EFSTATHOPOULOU, Shaimaa EL-ASHWAH, Alicia ENRICO, Alberto FRESA, Sara GALIMBERTI, Andrea GALITZIA, Rocío GARCÍA-SERRA, Eva GIMENO, Isabel GONZÁLEZ-GASCÓN-Y-MARÍN, Alessandro GOZZETTI, Valerio GUARENTE, Romain GUIEZE, Ajay GOGIA, Ritu GUPTA, Sean HARROP, Eleftheria HATZIMICHAEL, Yair HERISHANU, Hernández-Rivas JOSÉ-ÁNGEL, Luca INCHIAPPA, Ozren JAKSIC, Susanne JANSSEN, El$\backslash$.zbieta KALICI$\backslash$'NSKA, Laribi KAMEL, Volkan KARAKUS, Arnon P KATER, Bonnie KHO, Maria KISLOVA, Eliana KONSTANTINOU, Maya KOREN-MICHOWITZ, Ioannis KOTSIANIDIS, Robert J KREITMAN, Jorge LABRADOR, Deepesh LAD, Levin MARK-DAVID, Ilana LEVY, Thomas LONGVAL, Alberto LOPEZ-GARCIA, Juan MARQUET, Lucia MARTIN-RODRÍGUEZ, Marc MAYNADIÉ, Stanislava MASLEJOVA, Carlota MAYOR-BASTIDA, Biljana MIHALJEVIC, Ivana MILOSEVIC, Fatima MIRAS, Riccardo MOIA, Marta MORAWSKA, Roberta MURRU, Uttam Kumar NATH, Almudena NAVARRO-BAILÓN, Ana C OLIVEIRA, Jacopo OLIVIERI, David OSCIER, Irina PANOVSKA-STAVRIDIS, Maria PAPAIOANNOU, Tomas PAPAJÍK, Zuzana KUBOVA, Punyarat PHUMPHUKHIEO, Cheyenne PIERIE, Anna PUIGGROS, Lata RANI, Gianluigi REDA, Gian Matteo RIGOLIN, Rosa RUCHLEMER, Marcos Daniel de Deus SANTOS, Mattia SCHIPANI, Annett SCHIWITZA, Yandong SHEN, Martin SIMKOVIC, Svetlana SMIRNOVA, Dina Sameh Abdelrahman SOLIMAN, Martin SPACEK, Tamar TADMOR, Kristina TOMIC, Eric TSE, Theodoros VASSILAKOPOULOS, Andrea VISENTIN, Candida VITALE, Julia von TRESCKOW, George VRACHIOLIAS, Vojin VUKOVIC, Renata WALEWSKA, Ewa WASIK-SZCZEPANEK, Zhenshu XU, Munci YAGCI, Lucrecia YAÑEZ, Mohamed YASSIN, Jana ZUCHNICKA, Maria ANGELOPOULOU, Darko ANTIC, Bella BIDERMAN, Mark CATHERWOOD, Rainer CLAUS, Marta COSCIA, Antonio CUNEO, Fatih DEMIRKAN, Blanca ESPINET, Gianluca GAIDANO, Olga B KALASHNIKOVA, Luca LAURENTI, Eugene NIKITIN, Gerassimos A PANGALIS, Panagiotis PANAGIOTIDIS, Viola Maria POPOV, Sarka POSPISILOVA, Paolo SPORTOLETTI, Niki STAVROYIANNI, Constantine TAM, Livio TRENTIN, Anastasia CHATZIDIMITRIOU, Francesc BOSCH, Michael DOUBEK, Paolo GHIA and Kostas STAMATOPOULOS. Other malignancies in the history of CLL: an international multicenter study conducted by ERIC, the European Research Initiative on CLL, in HARMONY. \textit{EClinicalMedicine}. AMSTERDAM: ELSEVIER, 2023, vol.~65, November 2023, p.~1-14. ISSN~2589-5370. Available from: https://dx.doi.org/10.1016/j.eclinm.2023.102307.