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@article{2365618,
author = {Mazurakova, Alena and Solarova, Zuzana and Koklesova, Lenka and Caprnda, Martin and Prosecký, Robert and Khakymov, Artur and Baranenko, Denis and Kubatka, Peter and Mirossay, Ladislav and Kružliak, Peter and Solar, Peter},
article_location = {WROCLAW},
article_number = {2},
doi = {http://dx.doi.org/10.1016/j.advms.2023.10.005},
keywords = {HSPs; Cancer; Anti-Cancer therapy; Immunotherapy; Immunomodulation},
language = {eng},
issn = {1896-1126},
journal = {Advances in Medical Sciences},
title = {Heat shock proteins in cancer - Known but always being rediscovered: Their perspectives in cancer immunotherapy},
url = {https://www.sciencedirect.com/science/article/pii/S1896112623000457?via%3Dihub},
volume = {68},
year = {2023}
}
TY - JOUR
ID - 2365618
AU - Mazurakova, Alena - Solarova, Zuzana - Koklesova, Lenka - Caprnda, Martin - Prosecký, Robert - Khakymov, Artur - Baranenko, Denis - Kubatka, Peter - Mirossay, Ladislav - Kružliak, Peter - Solar, Peter
PY - 2023
TI - Heat shock proteins in cancer - Known but always being rediscovered: Their perspectives in cancer immunotherapy
JF - Advances in Medical Sciences
VL - 68
IS - 2
SP - 464-473
EP - 464-473
PB - ELSEVIER URBAN & PARTNER SP Z O O
SN - 18961126
KW - HSPs
KW - Cancer
KW - Anti-Cancer therapy
KW - Immunotherapy
KW - Immunomodulation
UR - https://www.sciencedirect.com/science/article/pii/S1896112623000457?via%3Dihub
N2 - Heat shock proteins (HSPs) represent cellular chaperones that are classified into several families, including HSP27, HSP40, HSP60, HSP70, and HSP90. The role of HSPs in the cell includes the facilitation of protein folding and maintaining protein structure. Both processes play crucial roles during stress conditions in the cell such as heat shock, degradation, and hypoxia. Moreover, HSPs are important modulators of cellular proliferation and differentiation, and are strongly associated with the molecular orchestration of carcinogenesis. The expression and/or activity of HSPs in cancer cells is generally abnormally high and is associated with increased metastatic potential and activity of cancer stem cells, more pronounced angiogenesis, downregulated apoptosis, and the resistance to anticancer therapy in many patients. Based on the mentioned reasons, HSPs have strong potential as valid diagnostic, prognostic, and therapeutic biomarkers in clinical oncology. In addition, numerous papers describe the role of HSPs as chaperones in the regulation of immune responses inside and outside the cell. Importantly, highly expressed/activated HSPs may be inhibited via immunotherapeutic targets in various types of cancers. The aim of this work is to provide a comprehensive overview of the relationship between HSPs and the tumor cell with the intention of highlighting the potential use of HSPs in personalized cancer management.
ER -
MAZURAKOVA, Alena, Zuzana SOLAROVA, Lenka KOKLESOVA, Martin CAPRNDA, Robert PROSECKÝ, Artur KHAKYMOV, Denis BARANENKO, Peter KUBATKA, Ladislav MIROSSAY, Peter KRUŽLIAK and Peter SOLAR. Heat shock proteins in cancer - Known but always being rediscovered: Their perspectives in cancer immunotherapy. \textit{Advances in Medical Sciences}. WROCLAW: ELSEVIER URBAN \&{} PARTNER SP Z O O, 2023, vol.~68, No~2, p.~464-473. ISSN~1896-1126. Available from: https://dx.doi.org/10.1016/j.advms.2023.10.005.
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