Nanoparticle-Based Bioaffinity Assays: From the Research
Laboratory to the Market

J 2024

Nanoparticle-Based Bioaffinity Assays: From the Research Laboratory to the Market

FARKA, Zdeněk, Julian BRANDMEIER, Matthias Jürgen MICKERT, Matěj PASTUCHA, Karel LACINA et. al.

Basic information

Original name

Nanoparticle-Based Bioaffinity Assays: From the Research Laboratory to the Market

Authors

FARKA, Zdeněk (203 Czech Republic, belonging to the institution), Julian BRANDMEIER (276 Germany, belonging to the institution), Matthias Jürgen MICKERT (276 Germany), Matěj PASTUCHA (203 Czech Republic, belonging to the institution), Karel LACINA (203 Czech Republic, belonging to the institution), Petr SKLÁDAL (203 Czech Republic, belonging to the institution), Tero SOUKKA (246 Finland) and Hans-Heiner GORRIS (276 Germany, guarantor, belonging to the institution)

Edition

Advanced Materials, Weinheim, Wiley-VCH, 2024, 0935-9648

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10406 Analytical chemistry

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 29.400 in 2022

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1002/adma.202307653

UT WoS

001118500300001

Keywords in English

bioaffinity assay; immunoassay; nanoparticle; nanomaterial; commercialization

Abstract

V originále

Advances in the development of new biorecognition elements, nanoparticle-based labels as well as instrumentation have inspired the design of new bioaffinity assays. This review critically discusses the potential of nanoparticles to replace current enzymatic or molecular labels in immunoassays and other bioaffinity assays. Successful implementations of nanoparticles in commercial assays and the need for rapid tests incorporating nanoparticles in different roles such as capture support, signal generation elements, and signal amplification systems are highlighted. The limited number of nanoparticles applied in current commercial assays can be explained by challenges associated with the analysis of real samples (e.g., blood, urine, or nasal swabs) that are difficult to resolve, particularly if the same performance can be achieved more easily by conventional labels. Lateral flow assays that are based on the visual detection of the red-colored line formed by colloidal gold are a notable exception, exemplified by SARS-CoV-2 rapid antigen tests that have moved from initial laboratory testing to widespread market adaption in less than two years.

Links

GF23-06199K, research and development project

Name: Nové anti-Stokesové lanthanoidové nanočástice a vícebarevný FRET mechanismy pro jednomolekulové sekvenování DNA

Investor: Czech Science Foundation, Novel anti-Stokes upconverting nanoparticles and multicolor FRET mechanisms for single-molecule DNA sequencing, Lead Agency

Citovat

FARKA, Zdeněk, Julian BRANDMEIER, Matthias Jürgen MICKERT, Matěj PASTUCHA, Karel LACINA, Petr SKLÁDAL, Tero SOUKKA and Hans-Heiner GORRIS. Nanoparticle-Based Bioaffinity Assays: From the Research Laboratory to the Market. Advanced Materials. Weinheim: Wiley-VCH, 2024, vol. 36, No 3, p. 1-23. ISSN 0935-9648. Available from: https://dx.doi.org/10.1002/adma.202307653.

@article{2366078,
   author = {Farka, Zdeněk and Brandmeier, Julian and Mickert, Matthias Jürgen and Pastucha, Matěj and Lacina, Karel and Skládal, Petr and Soukka, Tero and Gorris, HansandHeiner},
   article_location = {Weinheim},
   article_number = {3},
   doi = {http://dx.doi.org/10.1002/adma.202307653},
   keywords = {bioaffinity assay; immunoassay; nanoparticle; nanomaterial; commercialization},
   language = {eng},
   issn = {0935-9648},
   journal = {Advanced Materials},
   title = {Nanoparticle-Based Bioaffinity Assays: From the Research Laboratory to the Market},
   url = {https://onlinelibrary.wiley.com/doi/10.1002/adma.202307653},
   volume = {36},
   year = {2024}
}

TY  - JOUR
ID  - 2366078
AU  - Farka, Zdeněk - Brandmeier, Julian - Mickert, Matthias Jürgen - Pastucha, Matěj - Lacina, Karel - Skládal, Petr - Soukka, Tero - Gorris, Hans-Heiner
PY  - 2024
TI  - Nanoparticle-Based Bioaffinity Assays: From the Research Laboratory to the Market
JF  - Advanced Materials
VL  - 36
IS  - 3
SP  - 1-23
EP  - 1-23
PB  - Wiley-VCH
SN  - 09359648
KW  - bioaffinity assay
KW  - immunoassay
KW  - nanoparticle
KW  - nanomaterial
KW  - commercialization
UR  - https://onlinelibrary.wiley.com/doi/10.1002/adma.202307653
N2  - Advances in the development of new biorecognition elements, nanoparticle-based labels as well as instrumentation have inspired the design of new bioaffinity assays. This review critically discusses the potential of nanoparticles to replace current enzymatic or molecular labels in immunoassays and other bioaffinity assays. Successful implementations of nanoparticles in commercial assays and the need for rapid tests incorporating nanoparticles in different roles such as capture support, signal generation elements, and signal amplification systems are highlighted. The limited number of nanoparticles applied in current commercial assays can be explained by challenges associated with the analysis of real samples (e.g., blood, urine, or nasal swabs) that are difficult to resolve, particularly if the same performance can be achieved more easily by conventional labels. Lateral flow assays that are based on the visual detection of the red-colored line formed by colloidal gold are a notable exception, exemplified by SARS-CoV-2 rapid antigen tests that have moved from initial laboratory testing to widespread market adaption in less than two years.
ER  -

FARKA, Zdeněk, Julian BRANDMEIER, Matthias Jürgen MICKERT, Matěj PASTUCHA, Karel LACINA, Petr SKLÁDAL, Tero SOUKKA and Hans-Heiner GORRIS. Nanoparticle-Based Bioaffinity Assays: From the Research Laboratory to the Market. \textit{Advanced Materials}. Weinheim: Wiley-VCH, 2024, vol.~36, No~3, p.~1-23. ISSN~0935-9648. Available from: https://dx.doi.org/10.1002/adma.202307653.

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