The Impact of Subclinical Hypothyroidism on the Quality of Life
During Pregnancy: Mapping 5-Level Version of EQ-5D and
ThyPRO-39

J 2023

The Impact of Subclinical Hypothyroidism on the Quality of Life During Pregnancy: Mapping 5-Level Version of EQ-5D and ThyPRO-39

TUZIL, Jan, Barbora FILKOVA PILNACKOVA, Torquil WATT, Jan JISKRA, Marcela KOUDELKOVÁ et. al.

Basic information

Original name

The Impact of Subclinical Hypothyroidism on the Quality of Life During Pregnancy: Mapping 5-Level Version of EQ-5D and ThyPRO-39

Authors

TUZIL, Jan (203 Czech Republic, guarantor), Barbora FILKOVA PILNACKOVA (203 Czech Republic), Torquil WATT, Jan JISKRA (203 Czech Republic), Marcela KOUDELKOVÁ (203 Czech Republic, belonging to the institution), Eva NOVOTNA (203 Czech Republic), Klara TUZILOVA (203 Czech Republic), Tomáš DOLEŽAL (203 Czech Republic, belonging to the institution) and Jana BARTAKOVA (203 Czech Republic)

Edition

Value in health, NEW YORK, ELSEVIER SCIENCE INC, 2023, 1098-3015

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.500 in 2022

RIV identification code

RIV/00216224:14110/23:00133293

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.jval.2023.02.015

UT WoS

001029792800001

Keywords in English

EQ-5D; hypothyroidism; pregnancy; quality of life; ThyPRO-39

Abstract

V originále

Objectives: To describe how subclinical hypothyroidism (SubHypo) influences the quality of life (QoL) during pregnancy. Methods: In primary data collection (NCT04167423), thyroid stimulating hormone (TSH), free thyroxine (FT4), thyroid peroxidase antibodies, generic quality of life (QoL; 5-level version of EQ-5D [EQ-5D-5L]), and disease-specific QoL (ThyPRO-39) were measured among pregnant women. SubHypo during each trimester was defined according to the 2014 European Thyroid Association guidelines (TSH . 2.5, 3.0, and 3.5 IU/L, respectively; with normal FT4). Path analysis described relationships and tested mediation. Linear ordinary least squares, beta, tobit, and two-part regressions were used to map ThyPRO-39 and EQ-5D-5L. Alternative SubHypo definition was tested in sensitivity analysis. Results: A total of 253 women at 14 sites (31 & PLUSMN; 5 years old, 15 & PLUSMN; 6 weeks pregnant) completed the questionnaires. Sixty-one (26%) had SubHypo and differed from 174 (74%) euthyroid women in smoking history (61% vs 41%), primiparity (62% vs 43%) and TSH level (4.1 & PLUSMN; 1.4 vs 1.5 & PLUSMN; 0.7 mIU/L, P < .001). EQ-5D-5L utility in SubHypo (0.89 & PLUSMN; 0.12) was lower than that in euthyroid (0.92 & PLUSMN; 0.11; P = .028) even after adjustment (difference 20.04, P = .033), whereas ocular (P = .001, ThyPRO-39), cognitive symptoms (P = .043), anxiety (P < .0001), and the composite score were higher. The impact of SubHypo on utility was mediated by anxiety. Results were confirmed by sensitivity analysis. Final mapping equation (ordinary least squares) includes goiter symptoms, anxiety, upset stomach, composite score (ThyPRO-39), FT4 levels, and week of pregnancy (determination coefficient 0.36). Conclusion: This is the first QoL mapping of SubHypo during pregnancy and the first evidence that SubHypo is associated with a negative impact on QoL. The effect is mediated by anxiety. EQ-5D-5L utilities can be generated based on ThyPRO-39 scores collected in pregnant euthyroid and patients with SubHypo.

Citovat

TUZIL, Jan, Barbora FILKOVA PILNACKOVA, Torquil WATT, Jan JISKRA, Marcela KOUDELKOVÁ, Eva NOVOTNA, Klara TUZILOVA, Tomáš DOLEŽAL and Jana BARTAKOVA. The Impact of Subclinical Hypothyroidism on the Quality of Life During Pregnancy: Mapping 5-Level Version of EQ-5D and ThyPRO-39. Value in health. NEW YORK: ELSEVIER SCIENCE INC, 2023, vol. 26, No 7, p. 1085-1097. ISSN 1098-3015. Available from: https://dx.doi.org/10.1016/j.jval.2023.02.015.

@article{2367150,
   author = {Tuzil, Jan and Filkova Pilnackova, Barbora and Watt, Torquil and Jiskra, Jan and Koudelková, Marcela and Novotna, Eva and Tuzilova, Klara and Doležal, Tomáš and Bartakova, Jana},
   article_location = {NEW YORK},
   article_number = {7},
   doi = {http://dx.doi.org/10.1016/j.jval.2023.02.015},
   keywords = {EQ-5D; hypothyroidism; pregnancy; quality of life; ThyPRO-39},
   language = {eng},
   issn = {1098-3015},
   journal = {Value in health},
   title = {The Impact of Subclinical Hypothyroidism on the Quality of Life During Pregnancy: Mapping 5-Level Version of EQ-5D and ThyPRO-39},
   url = {https://www.sciencedirect.com/science/article/pii/S1098301523000645?via%3Dihub},
   volume = {26},
   year = {2023}
}

TY  - JOUR
ID  - 2367150
AU  - Tuzil, Jan - Filkova Pilnackova, Barbora - Watt, Torquil - Jiskra, Jan - Koudelková, Marcela - Novotna, Eva - Tuzilova, Klara - Doležal, Tomáš - Bartakova, Jana
PY  - 2023
TI  - The Impact of Subclinical Hypothyroidism on the Quality of Life During Pregnancy: Mapping 5-Level Version of EQ-5D and ThyPRO-39
JF  - Value in health
VL  - 26
IS  - 7
SP  - 1085-1097
EP  - 1085-1097
PB  - ELSEVIER SCIENCE INC
SN  - 10983015
KW  - EQ-5D
KW  - hypothyroidism
KW  - pregnancy
KW  - quality of life
KW  - ThyPRO-39
UR  - https://www.sciencedirect.com/science/article/pii/S1098301523000645?via%3Dihub
N2  - Objectives: To describe how subclinical hypothyroidism (SubHypo) influences the quality of life (QoL) during pregnancy. Methods: In primary data collection (NCT04167423), thyroid stimulating hormone (TSH), free thyroxine (FT4), thyroid peroxidase antibodies, generic quality of life (QoL; 5-level version of EQ-5D [EQ-5D-5L]), and disease-specific QoL (ThyPRO-39) were measured among pregnant women. SubHypo during each trimester was defined according to the 2014 European Thyroid Association guidelines (TSH . 2.5, 3.0, and 3.5 IU/L, respectively; with normal FT4). Path analysis described relationships and tested mediation. Linear ordinary least squares, beta, tobit, and two-part regressions were used to map ThyPRO-39 and EQ-5D-5L. Alternative SubHypo definition was tested in sensitivity analysis. Results: A total of 253 women at 14 sites (31 & PLUSMN; 5 years old, 15 & PLUSMN; 6 weeks pregnant) completed the questionnaires. Sixty-one (26%) had SubHypo and differed from 174 (74%) euthyroid women in smoking history (61% vs 41%), primiparity (62% vs 43%) and TSH level (4.1 & PLUSMN; 1.4 vs 1.5 & PLUSMN; 0.7 mIU/L, P < .001). EQ-5D-5L utility in SubHypo (0.89 & PLUSMN; 0.12) was lower than that in euthyroid (0.92 & PLUSMN; 0.11; P = .028) even after adjustment (difference 20.04, P = .033), whereas ocular (P = .001, ThyPRO-39), cognitive symptoms (P = .043), anxiety (P < .0001), and the composite score were higher. The impact of SubHypo on utility was mediated by anxiety. Results were confirmed by sensitivity analysis. Final mapping equation (ordinary least squares) includes goiter symptoms, anxiety, upset stomach, composite score (ThyPRO-39), FT4 levels, and week of pregnancy (determination coefficient 0.36). Conclusion: This is the first QoL mapping of SubHypo during pregnancy and the first evidence that SubHypo is associated with a negative impact on QoL. The effect is mediated by anxiety. EQ-5D-5L utilities can be generated based on ThyPRO-39 scores collected in pregnant euthyroid and patients with SubHypo.
ER  -

TUZIL, Jan, Barbora FILKOVA PILNACKOVA, Torquil WATT, Jan JISKRA, Marcela KOUDELKOVÁ, Eva NOVOTNA, Klara TUZILOVA, Tomáš DOLEŽAL and Jana BARTAKOVA. The Impact of Subclinical Hypothyroidism on the Quality of Life During Pregnancy: Mapping 5-Level Version of EQ-5D and ThyPRO-39. \textit{Value in health}. NEW YORK: ELSEVIER SCIENCE INC, 2023, vol.~26, No~7, p.~1085-1097. ISSN~1098-3015. Available from: https://dx.doi.org/10.1016/j.jval.2023.02.015.

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