Other formats:
BibTeX
LaTeX
RIS
@article{2367156,
author = {Cruciani, Mario and White, P Lewis and Barnes, Rosemary A and Loeffler, Juergen and Donnelly, J Peter and Rogers, Thomas R and Heinz, Werner J and Warris, Adilia and Morton, Charles Oliver and Lengerová, Martina and Klingspor, Lena and Sendid, Boualem and Lockhart, Deborah E A},
article_location = {St. Alban-Anlage},
article_number = {10},
doi = {http://dx.doi.org/10.3390/jof9100967},
keywords = {systematic review; meta-analysis; umbrella review; Aspergillus fumigatus; invasive aspergillosis; diagnosis; polymerase chain reaction (PCR)},
language = {eng},
issn = {2309-608X},
journal = {Journal of Fungi},
title = {An Overview of Systematic Reviews of Polymerase Chain Reaction (PCR) for the Diagnosis of Invasive Aspergillosis in Immunocompromised People: A Report of the Fungal PCR Initiative (FPCRI)-An ISHAM Working Group},
url = {https://www.mdpi.com/2309-608X/9/10/967},
volume = {9},
year = {2023}
}
TY - JOUR
ID - 2367156
AU - Cruciani, Mario - White, P Lewis - Barnes, Rosemary A - Loeffler, Juergen - Donnelly, J Peter - Rogers, Thomas R - Heinz, Werner J - Warris, Adilia - Morton, Charles Oliver - Lengerová, Martina - Klingspor, Lena - Sendid, Boualem - Lockhart, Deborah E A
PY - 2023
TI - An Overview of Systematic Reviews of Polymerase Chain Reaction (PCR) for the Diagnosis of Invasive Aspergillosis in Immunocompromised People: A Report of the Fungal PCR Initiative (FPCRI)-An ISHAM Working Group
JF - Journal of Fungi
VL - 9
IS - 10
SP - 1-15
EP - 1-15
PB - MDPI
SN - 2309608X
KW - systematic review
KW - meta-analysis
KW - umbrella review
KW - Aspergillus fumigatus
KW - invasive aspergillosis
KW - diagnosis
KW - polymerase chain reaction (PCR)
UR - https://www.mdpi.com/2309-608X/9/10/967
N2 - This overview of reviews (i.e., an umbrella review) is designed to reappraise the validity of systematic reviews (SRs) and meta-analyses related to the performance of Aspergillus PCR tests for the diagnosis of invasive aspergillosis in immunocompromised patients. The methodological quality of the SRs was assessed using the AMSTAR-2 checklist; the quality of the evidence (QOE) within each SR was appraised following the GRADE approach. Eight out of 12 SRs were evaluated for qualitative and quantitative assessment. Five SRs evaluated Aspergillus PCR on bronchoalveolar lavage fluid (BAL) and three on blood specimens. The eight SRs included 167 overlapping reports (59 evaluating PCR in blood specimens, and 108 in BAL), based on 107 individual primary studies (98 trials with a cohort design, and 19 with a case-control design). In BAL specimens, the mean sensitivity and specificity ranged from 0.57 to 0.91, and from 0.92 to 0.97, respectively (QOE: very low to low). In blood specimens (whole blood or serum), the mean sensitivity ranged from 0.57 to 0.84, and the mean specificity from 0.58 to 0.95 (QOE: low to moderate). Across studies, only a low proportion of AMSTAR-2 critical domains were unmet (1.8%), demonstrating a high quality of methodological assessment. Conclusions. Based on the overall methodological assessment of the reviews included, on average we can have high confidence in the quality of results generated by the SRs.
ER -
CRUCIANI, Mario, P Lewis WHITE, Rosemary A BARNES, Juergen LOEFFLER, J Peter DONNELLY, Thomas R ROGERS, Werner J HEINZ, Adilia WARRIS, Charles Oliver MORTON, Martina LENGEROVÁ, Lena KLINGSPOR, Boualem SENDID and Deborah E A LOCKHART. An Overview of Systematic Reviews of Polymerase Chain Reaction (PCR) for the Diagnosis of Invasive Aspergillosis in Immunocompromised People: A Report of the Fungal PCR Initiative (FPCRI)-An ISHAM Working Group. \textit{Journal of Fungi}. St. Alban-Anlage: MDPI, 2023, vol.~9, No~10, p.~1-15. ISSN~2309-608X. Available from: https://dx.doi.org/10.3390/jof9100967.
|
