Diabetes Mellitus in Pancreatic Cancer: A Distinct Approach to
Older Subjects with New-Onset Diabetes Mellitus

J 2023

Diabetes Mellitus in Pancreatic Cancer: A Distinct Approach to Older Subjects with New-Onset Diabetes Mellitus

BURES, Jan, Darina KOHOUTOVA, Jan SKRHA, Bohus BUNGANIC, Ondřej NGO et. al.

Basic information

Original name

Diabetes Mellitus in Pancreatic Cancer: A Distinct Approach to Older Subjects with New-Onset Diabetes Mellitus

Authors

BURES, Jan (203 Czech Republic, guarantor), Darina KOHOUTOVA (203 Czech Republic), Jan SKRHA (203 Czech Republic), Bohus BUNGANIC (203 Czech Republic), Ondřej NGO (203 Czech Republic, belonging to the institution), Stepan SUCHANEK (203 Czech Republic), Pavel SKRHA (203 Czech Republic) and Miroslav ZAVORAL (203 Czech Republic)

Edition

Cancers, BASEL, MDPI, 2023, 2072-6694

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.200 in 2022

RIV identification code

RIV/00216224:14110/23:00133296

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3390/cancers15143669

UT WoS

001035234500001

Keywords in English

age over 60 years; diagnostic algorithm; new-onset diabetes mellitus; pancreatic ductal adenocarcinoma

Abstract

V originále

Simple Summary Pancreatic ductal adenocarcinoma remains one of the most serious malignancies and a leading cause of cancer-related deaths worldwide. There are no effective screening methods available so far, even for high-risk individuals. At the time of diagnosis, impaired glucose metabolism is present in about 3/4 of all patients. Several types of diabetes mellitus can be found in pancreatic cancer; however, type 2, pancreatic-cancer-associated type 3c, and diabetes mellitus associated with non-malignant diseases of the exocrine pancreas (with a reduction or loss of islet-cell mass) are the most frequent ones. This paper proposed a distinct approach to older subjects with new-onset diabetes mellitus with possible pancreatic cancer. It could improve the current unsatisfactory situation in diagnostics and subsequent poor outcomes of treatment of pancreatic ductal adenocarcinoma. Background: Pancreatic ductal adenocarcinoma (PDAC) is associated with a very poor prognosis, with near-identical incidence and mortality. According to the World Health Organization Globocan Database, the estimated number of new cases worldwide will rise by 70% between 2020 and 2040. There are no effective screening methods available so far, even for high-risk individuals. The prognosis of PDAC, even at its early stages, is still mostly unsatisfactory. Impaired glucose metabolism is present in about 3/4 of PDAC cases. Methods: Available literature on pancreatic cancer and diabetes mellitus was reviewed using a PubMed database. Data from a national oncology registry (on PDAC) and information from a registry of healthcare providers (on diabetes mellitus and a number of abdominal ultrasound investigations) were obtained. Results: New-onset diabetes mellitus in subjects older than 60 years should be an incentive for a prompt and detailed investigation to exclude PDAC. Type 2 diabetes mellitus, diabetes mellitus associated with chronic non-malignant diseases of the exocrine pancreas, and PDAC-associated type 3c diabetes mellitus are the most frequent types. Proper differentiation of particular types of new-onset diabetes mellitus is a starting point for a population-based program. An algorithm for subsequent steps of the workup was proposed. Conclusions: The structured, well-differentiated, and elaborately designed approach to the elderly with a new onset of diabetes mellitus could improve the current situation in diagnostics and subsequent poor outcomes of therapy of PDAC.

Citovat

BURES, Jan, Darina KOHOUTOVA, Jan SKRHA, Bohus BUNGANIC, Ondřej NGO, Stepan SUCHANEK, Pavel SKRHA and Miroslav ZAVORAL. Diabetes Mellitus in Pancreatic Cancer: A Distinct Approach to Older Subjects with New-Onset Diabetes Mellitus. Cancers. BASEL: MDPI, 2023, vol. 15, No 14, p. 1-15. ISSN 2072-6694. Available from: https://dx.doi.org/10.3390/cancers15143669.

@article{2367181,
   author = {Bures, Jan and Kohoutova, Darina and Skrha, Jan and Bunganic, Bohus and Ngo, Ondřej and Suchanek, Stepan and Skrha, Pavel and Zavoral, Miroslav},
   article_location = {BASEL},
   article_number = {14},
   doi = {http://dx.doi.org/10.3390/cancers15143669},
   keywords = {age over 60 years; diagnostic algorithm; new-onset diabetes mellitus; pancreatic ductal adenocarcinoma},
   language = {eng},
   issn = {2072-6694},
   journal = {Cancers},
   title = {Diabetes Mellitus in Pancreatic Cancer: A Distinct Approach to Older Subjects with New-Onset Diabetes Mellitus},
   url = {https://www.mdpi.com/2072-6694/15/14/3669},
   volume = {15},
   year = {2023}
}

TY  - JOUR
ID  - 2367181
AU  - Bures, Jan - Kohoutova, Darina - Skrha, Jan - Bunganic, Bohus - Ngo, Ondřej - Suchanek, Stepan - Skrha, Pavel - Zavoral, Miroslav
PY  - 2023
TI  - Diabetes Mellitus in Pancreatic Cancer: A Distinct Approach to Older Subjects with New-Onset Diabetes Mellitus
JF  - Cancers
VL  - 15
IS  - 14
SP  - 1-15
EP  - 1-15
PB  - MDPI
SN  - 20726694
KW  - age over 60 years
KW  - diagnostic algorithm
KW  - new-onset diabetes mellitus
KW  - pancreatic ductal adenocarcinoma
UR  - https://www.mdpi.com/2072-6694/15/14/3669
N2  - Simple Summary Pancreatic ductal adenocarcinoma remains one of the most serious malignancies and a leading cause of cancer-related deaths worldwide. There are no effective screening methods available so far, even for high-risk individuals. At the time of diagnosis, impaired glucose metabolism is present in about 3/4 of all patients. Several types of diabetes mellitus can be found in pancreatic cancer; however, type 2, pancreatic-cancer-associated type 3c, and diabetes mellitus associated with non-malignant diseases of the exocrine pancreas (with a reduction or loss of islet-cell mass) are the most frequent ones. This paper proposed a distinct approach to older subjects with new-onset diabetes mellitus with possible pancreatic cancer. It could improve the current unsatisfactory situation in diagnostics and subsequent poor outcomes of treatment of pancreatic ductal adenocarcinoma. Background: Pancreatic ductal adenocarcinoma (PDAC) is associated with a very poor prognosis, with near-identical incidence and mortality. According to the World Health Organization Globocan Database, the estimated number of new cases worldwide will rise by 70% between 2020 and 2040. There are no effective screening methods available so far, even for high-risk individuals. The prognosis of PDAC, even at its early stages, is still mostly unsatisfactory. Impaired glucose metabolism is present in about 3/4 of PDAC cases. Methods: Available literature on pancreatic cancer and diabetes mellitus was reviewed using a PubMed database. Data from a national oncology registry (on PDAC) and information from a registry of healthcare providers (on diabetes mellitus and a number of abdominal ultrasound investigations) were obtained. Results: New-onset diabetes mellitus in subjects older than 60 years should be an incentive for a prompt and detailed investigation to exclude PDAC. Type 2 diabetes mellitus, diabetes mellitus associated with chronic non-malignant diseases of the exocrine pancreas, and PDAC-associated type 3c diabetes mellitus are the most frequent types. Proper differentiation of particular types of new-onset diabetes mellitus is a starting point for a population-based program. An algorithm for subsequent steps of the workup was proposed. Conclusions: The structured, well-differentiated, and elaborately designed approach to the elderly with a new onset of diabetes mellitus could improve the current situation in diagnostics and subsequent poor outcomes of therapy of PDAC.
ER  -

BURES, Jan, Darina KOHOUTOVA, Jan SKRHA, Bohus BUNGANIC, Ondřej NGO, Stepan SUCHANEK, Pavel SKRHA and Miroslav ZAVORAL. Diabetes Mellitus in Pancreatic Cancer: A Distinct Approach to Older Subjects with New-Onset Diabetes Mellitus. \textit{Cancers}. BASEL: MDPI, 2023, vol.~15, No~14, p.~1-15. ISSN~2072-6694. Available from: https://dx.doi.org/10.3390/cancers15143669.

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