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@article{2367181,
author = {Bures, Jan and Kohoutova, Darina and Skrha, Jan and Bunganic, Bohus and Ngo, Ondřej and Suchanek, Stepan and Skrha, Pavel and Zavoral, Miroslav},
article_location = {BASEL},
article_number = {14},
doi = {http://dx.doi.org/10.3390/cancers15143669},
keywords = {age over 60 years; diagnostic algorithm; new-onset diabetes mellitus; pancreatic ductal adenocarcinoma},
language = {eng},
issn = {2072-6694},
journal = {Cancers},
title = {Diabetes Mellitus in Pancreatic Cancer: A Distinct Approach to Older Subjects with New-Onset Diabetes Mellitus},
url = {https://www.mdpi.com/2072-6694/15/14/3669},
volume = {15},
year = {2023}
}
TY - JOUR
ID - 2367181
AU - Bures, Jan - Kohoutova, Darina - Skrha, Jan - Bunganic, Bohus - Ngo, Ondřej - Suchanek, Stepan - Skrha, Pavel - Zavoral, Miroslav
PY - 2023
TI - Diabetes Mellitus in Pancreatic Cancer: A Distinct Approach to Older Subjects with New-Onset Diabetes Mellitus
JF - Cancers
VL - 15
IS - 14
SP - 1-15
EP - 1-15
PB - MDPI
SN - 20726694
KW - age over 60 years
KW - diagnostic algorithm
KW - new-onset diabetes mellitus
KW - pancreatic ductal adenocarcinoma
UR - https://www.mdpi.com/2072-6694/15/14/3669
N2 - Simple Summary Pancreatic ductal adenocarcinoma remains one of the most serious malignancies and a leading cause of cancer-related deaths worldwide. There are no effective screening methods available so far, even for high-risk individuals. At the time of diagnosis, impaired glucose metabolism is present in about 3/4 of all patients. Several types of diabetes mellitus can be found in pancreatic cancer; however, type 2, pancreatic-cancer-associated type 3c, and diabetes mellitus associated with non-malignant diseases of the exocrine pancreas (with a reduction or loss of islet-cell mass) are the most frequent ones. This paper proposed a distinct approach to older subjects with new-onset diabetes mellitus with possible pancreatic cancer. It could improve the current unsatisfactory situation in diagnostics and subsequent poor outcomes of treatment of pancreatic ductal adenocarcinoma. Background: Pancreatic ductal adenocarcinoma (PDAC) is associated with a very poor prognosis, with near-identical incidence and mortality. According to the World Health Organization Globocan Database, the estimated number of new cases worldwide will rise by 70% between 2020 and 2040. There are no effective screening methods available so far, even for high-risk individuals. The prognosis of PDAC, even at its early stages, is still mostly unsatisfactory. Impaired glucose metabolism is present in about 3/4 of PDAC cases. Methods: Available literature on pancreatic cancer and diabetes mellitus was reviewed using a PubMed database. Data from a national oncology registry (on PDAC) and information from a registry of healthcare providers (on diabetes mellitus and a number of abdominal ultrasound investigations) were obtained. Results: New-onset diabetes mellitus in subjects older than 60 years should be an incentive for a prompt and detailed investigation to exclude PDAC. Type 2 diabetes mellitus, diabetes mellitus associated with chronic non-malignant diseases of the exocrine pancreas, and PDAC-associated type 3c diabetes mellitus are the most frequent types. Proper differentiation of particular types of new-onset diabetes mellitus is a starting point for a population-based program. An algorithm for subsequent steps of the workup was proposed. Conclusions: The structured, well-differentiated, and elaborately designed approach to the elderly with a new onset of diabetes mellitus could improve the current situation in diagnostics and subsequent poor outcomes of therapy of PDAC.
ER -
BURES, Jan, Darina KOHOUTOVA, Jan SKRHA, Bohus BUNGANIC, Ondřej NGO, Stepan SUCHANEK, Pavel SKRHA and Miroslav ZAVORAL. Diabetes Mellitus in Pancreatic Cancer: A Distinct Approach to Older Subjects with New-Onset Diabetes Mellitus. \textit{Cancers}. BASEL: MDPI, 2023, vol.~15, No~14, p.~1-15. ISSN~2072-6694. Available from: https://dx.doi.org/10.3390/cancers15143669.
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