Histone H1 protects telomeric repeats from H3K27me3 invasion in
Arabidopsis

J 2023

Histone H1 protects telomeric repeats from H3K27me3 invasion in Arabidopsis

TEANO, Gianluca, Lorenzo CONCIA, Lea WOLFF, Leopold CARRON, Ivona BIOCANIN et. al.

Basic information

Original name

Histone H1 protects telomeric repeats from H3K27me3 invasion in Arabidopsis

Authors

TEANO, Gianluca, Lorenzo CONCIA, Lea WOLFF, Leopold CARRON, Ivona BIOCANIN, Kateřina ADAMUSOVÁ (203 Czech Republic, belonging to the institution), Miloslava FOJTOVÁ (203 Czech Republic, belonging to the institution), Michael BOURGE, Amira KRAMDI, Vincent COLOT, Ueli GROSSNIKLAUS, Chris BOWLER, Celia BAROUX, Alessandra CARBONE, Aline V PROBST, Petra PROCHÁZKOVÁ SCHRUMPFOVÁ (203 Czech Republic, belonging to the institution), Jiří FAJKUS (203 Czech Republic, belonging to the institution), Simon AMIARD, Stefan GROB, Clara BOURBOUSSE and Fredy BARNECHE (guarantor)

Edition

Cell Reports, Elsevier, 2023, 2211-1247

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10611 Plant sciences, botany

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 8.800 in 2022

RIV identification code

RIV/00216224:14740/23:00133328

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1016/j.celrep.2023.112894

UT WoS

001057847700001

Keywords in English

3D chromosome organization; Arabidopsis; chromatin accessibility; CP: Molecular biology; CP: Plants; H3K27me3; linker histone H1; Polycomb; telomere; Telomere Repeat Binding protein; TRB

Abstract

V originále

While the pivotal role of linker histone H1 in shaping nucleosome organization is well established, its func-tional interplays with chromatin factors along the epigenome are just starting to emerge. Here we show that, in Arabidopsis, as in mammals, H1 occupies Polycomb Repressive Complex 2 (PRC2) target genes where it favors chromatin condensation and H3K27me3 deposition. We further show that, contrasting with its conserved function in PRC2 activation at genes, H1 selectively prevents H3K27me3 accumulation at telo-meres and large pericentromeric interstitial telomeric repeat (ITR) domains by restricting DNA accessibility to Telomere Repeat Binding (TRB) proteins, a group of H1-related Myb factors mediating PRC2 cis recruitment. This study provides a mechanistic framework by which H1 avoids the formation of gigantic H3K27me3-rich domains at telomeric sequences and contributes to safeguard nucleus architecture.

Links

GX20-01331X, research and development project

Name: Biogeneze a evoluce telomerázy u rostlin

Investor: Czech Science Foundation

LTC20003, research and development project

Name: Dynamics of telomeres and rDNA loci in plant cell nuclei

Investor: Ministry of Education, Youth and Sports of the CR, INTER-COST

Citovat

TEANO, Gianluca, Lorenzo CONCIA, Lea WOLFF, Leopold CARRON, Ivona BIOCANIN, Kateřina ADAMUSOVÁ, Miloslava FOJTOVÁ, Michael BOURGE, Amira KRAMDI, Vincent COLOT, Ueli GROSSNIKLAUS, Chris BOWLER, Celia BAROUX, Alessandra CARBONE, Aline V PROBST, Petra PROCHÁZKOVÁ SCHRUMPFOVÁ, Jiří FAJKUS, Simon AMIARD, Stefan GROB, Clara BOURBOUSSE and Fredy BARNECHE. Histone H1 protects telomeric repeats from H3K27me3 invasion in Arabidopsis. Cell Reports. Elsevier, 2023, vol. 42, No 8, p. 1-23. ISSN 2211-1247. Available from: https://dx.doi.org/10.1016/j.celrep.2023.112894.

@article{2367721,
   author = {Teano, Gianluca and Concia, Lorenzo and Wolff, Lea and Carron, Leopold and Biocanin, Ivona and Adamusová, Kateřina and Fojtová, Miloslava and Bourge, Michael and Kramdi, Amira and Colot, Vincent and Grossniklaus, Ueli and Bowler, Chris and Baroux, Celia and Carbone, Alessandra and Probst, Aline V and Procházková Schrumpfová, Petra and Fajkus, Jiří and Amiard, Simon and Grob, Stefan and Bourbousse, Clara and Barneche, Fredy},
   article_number = {8},
   doi = {http://dx.doi.org/10.1016/j.celrep.2023.112894},
   keywords = {3D chromosome organization; Arabidopsis; chromatin accessibility; CP: Molecular biology; CP: Plants; H3K27me3; linker histone H1; Polycomb; telomere; Telomere Repeat Binding protein; TRB},
   language = {eng},
   issn = {2211-1247},
   journal = {Cell Reports},
   title = {Histone H1 protects telomeric repeats from H3K27me3 invasion in Arabidopsis},
   url = {https://www.sciencedirect.com/science/article/pii/S2211124723009051},
   volume = {42},
   year = {2023}
}

TY  - JOUR
ID  - 2367721
AU  - Teano, Gianluca - Concia, Lorenzo - Wolff, Lea - Carron, Leopold - Biocanin, Ivona - Adamusová, Kateřina - Fojtová, Miloslava - Bourge, Michael - Kramdi, Amira - Colot, Vincent - Grossniklaus, Ueli - Bowler, Chris - Baroux, Celia - Carbone, Alessandra - Probst, Aline V - Procházková Schrumpfová, Petra - Fajkus, Jiří - Amiard, Simon - Grob, Stefan - Bourbousse, Clara - Barneche, Fredy
PY  - 2023
TI  - Histone H1 protects telomeric repeats from H3K27me3 invasion in Arabidopsis
JF  - Cell Reports
VL  - 42
IS  - 8
SP  - 1-23
EP  - 1-23
PB  - Elsevier
SN  - 22111247
KW  - 3D chromosome organization
KW  - Arabidopsis
KW  - chromatin accessibility
KW  - CP: Molecular biology
KW  - CP: Plants
KW  - H3K27me3
KW  - linker histone H1
KW  - Polycomb
KW  - telomere
KW  - Telomere Repeat Binding protein
KW  - TRB
UR  - https://www.sciencedirect.com/science/article/pii/S2211124723009051
N2  - While the pivotal role of linker histone H1 in shaping nucleosome organization is well established, its func-tional interplays with chromatin factors along the epigenome are just starting to emerge. Here we show that, in Arabidopsis, as in mammals, H1 occupies Polycomb Repressive Complex 2 (PRC2) target genes where it favors chromatin condensation and H3K27me3 deposition. We further show that, contrasting with its conserved function in PRC2 activation at genes, H1 selectively prevents H3K27me3 accumulation at telo-meres and large pericentromeric interstitial telomeric repeat (ITR) domains by restricting DNA accessibility to Telomere Repeat Binding (TRB) proteins, a group of H1-related Myb factors mediating PRC2 cis recruitment. This study provides a mechanistic framework by which H1 avoids the formation of gigantic H3K27me3-rich domains at telomeric sequences and contributes to safeguard nucleus architecture.
ER  -

TEANO, Gianluca, Lorenzo CONCIA, Lea WOLFF, Leopold CARRON, Ivona BIOCANIN, Kateřina ADAMUSOVÁ, Miloslava FOJTOVÁ, Michael BOURGE, Amira KRAMDI, Vincent COLOT, Ueli GROSSNIKLAUS, Chris BOWLER, Celia BAROUX, Alessandra CARBONE, Aline V PROBST, Petra PROCHÁZKOVÁ SCHRUMPFOVÁ, Jiří FAJKUS, Simon AMIARD, Stefan GROB, Clara BOURBOUSSE and Fredy BARNECHE. Histone H1 protects telomeric repeats from H3K27me3 invasion in Arabidopsis. \textit{Cell Reports}. Elsevier, 2023, vol.~42, No~8, p.~1-23. ISSN~2211-1247. Available from: https://dx.doi.org/10.1016/j.celrep.2023.112894.

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