J 2023

Early-onset pancreatic cancer: A national cancer registry study from the Czech Republic and review of the literature

WHITLEY, Adam, Petr KOCIAN, Andrej NIKOV, Denisa KREJČÍ, Lucie KŮSOVÁ et. al.

Basic information

Original name

Early-onset pancreatic cancer: A national cancer registry study from the Czech Republic and review of the literature

Authors

WHITLEY, Adam, Petr KOCIAN (203 Czech Republic, guarantor), Andrej NIKOV, Denisa KREJČÍ (203 Czech Republic, belonging to the institution), Lucie KŮSOVÁ (203 Czech Republic, belonging to the institution), Milan BLAHA (203 Czech Republic, belonging to the institution), Ladislav DUŠEK (203 Czech Republic, belonging to the institution) and Robert GURLICH (203 Czech Republic)

Edition

JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES, Hoboken, WILEY, 2023, 1868-6974

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30219 Gastroenterology and hepatology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 3.000 in 2022

RIV identification code

RIV/00216224:14110/23:00133339

Organization unit

Faculty of Medicine

DOI

UT WoS

001073545100001

Keywords in English

adult; pancreatic neoplasms; population register; survival; young adult

Tags

Tags

International impact, Reviewed
Změněno: 5/4/2024 09:23, Mgr. Tereza Miškechová

Abstract

V originále

Background: The aim of this study was to compare trends in mortality and incidence, clinicopathological features and survival of patients diagnosed with pancreatic ductal adenocarcinoma under 50 years of age (early-onset pancreatic cancer [EOPC]) with patients diagnosed over 50 years of age (late-onset pancreatic cancer [LOPC]).Methods: The national oncological registry of the Czech Republic was reviewed to identify all patients with histologically confirmed pancreatic ductal adenocarcinoma diagnosed between the years 1985 and 2015. Incidence, mortality, clinicopathological and survival data were analyzed and compared between patients with EOPC and LOPC.Results: From a total of 18 888 patients included in the study, 1324 patients were under the age of 50 years (7.0%). The average annual percentage changes (AAPC) in incidence of all patients with EOPC was -1.0%. The APPC for male patients with EOPC was -2.0% and for female patients was +0.6%. The AAPC in incidence for LOPC was +1.3%. There were no differences in tumor stage, grade or location between EOPC and LOPC. Young patients were more frequently male (64.4% vs. 52.9%), more frequently underwent treatment and had better overall survival. The median survival interval for EOPC was 5.9 months and for LOPC was 4.5 months (p < .001).Conclusions: The clinicopathological features of pancreatic ductal adenocarcinoma were similar in patients under and over the age of 50 years. Patients with EOPC survived longer than patients with LOPC. Continued efforts should be made to diagnose early and treat young patients aggressively.