RETRO-POPE: A Retrospective, Multicenter, Real-World Study of
All-Cause Mortality in COPD

J 2023

RETRO-POPE: A Retrospective, Multicenter, Real-World Study of All-Cause Mortality in COPD

KOBLIZEK, Vladimir, Branislava MILENKOVIC, Michal SVOBODA, Jana KOCIANOVA, Stanislav HOLUB et. al.

Basic information

Original name

RETRO-POPE: A Retrospective, Multicenter, Real-World Study of All-Cause Mortality in COPD

Authors

KOBLIZEK, Vladimir (203 Czech Republic), Branislava MILENKOVIC (203 Czech Republic), Michal SVOBODA (203 Czech Republic, belonging to the institution), Jana KOCIANOVA (203 Czech Republic), Stanislav HOLUB (203 Czech Republic), Vladimir ZINDR (203 Czech Republic), Miroslav ILIC (203 Czech Republic), Jelena JANKOVIC (203 Czech Republic), Vojislav CUPURDIJA, Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution), Boris POPOV and Arschang VALIPOUR

Edition

International Journal of chronic obstructive pulmonary disease, Albany, Dove Medical Press Ltd. 2023, 1178-2005

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30203 Respiratory systems

Country of publisher

New Zealand

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.800 in 2022

RIV identification code

RIV/00216224:14110/23:00133349

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.2147/COPD.S426919

UT WoS

001109137500001

Keywords in English

COPD; survival; mortality; Central and Eastern Europe; respiratory; clinical phenotype; cluster

Abstract

V originále

Purpose: The Phenotypes of COPD in Central and Eastern Europe (POPE) study assessed the prevalence and clinical characteristics of four clinical COPD phenotypes, but not mortality. This retrospective analysis of the POPE study (RETRO-POPE) investigated the relationship between all-cause mortality and patient characteristics using two grouping methods: clinical phenotyping (as in POPE) and Burgel clustering, to better identify high-risk patients.Patients and Methods: The two largest POPE study patient cohorts (Czech Republic and Serbia) were categorized into one of four clinical phenotypes (acute exacerbators [with/without chronic bronchitis], non-exacerbators, asthma-COPD overlap), and one of five Burgel clusters based on comorbidities, lung function, age, body mass index (BMI) and dyspnea (very severe comorbid, very severe respiratory, moderate-to-severe respiratory, moderate-to-severe comorbid/obese, and mild respiratory). Patients were followed-up for approximately 7 years for survival status.Results: Overall, 801 of 1,003 screened patients had sufficient data for analysis. Of these, 440 patients (54.9%) were alive and 361 (45.1%) had died at the end of follow-up. Analysis of survival by clinical phenotype showed no significant differences between the phenotypes (P=0.211). However, Burgel clustering demonstrated significant differences in survival between clusters (P<0.001), with patients in the "very severe comorbid" and "very severe respiratory" clusters most likely to die. Overall survival was not significantly different between Serbia and the Czech Republic after adjustment for age, BMI, comorbidities and forced expiratory volume in 1 second (hazard ratio [HR] 0.80, 95% confidence interval [CI] 0.65-0.99; P=0.036 [unadjusted]; HR 0.88, 95% CI 0.7-1.1; P=0.257 [adjusted]). The most common causes of death were respiratory-related (36.8%), followed by cardiovascular (25.2%) then neoplasm (15.2%).Conclusion: Patient clusters based on comorbidities, lung function, age, BMI and dyspnea were more likely to show differences in COPD mortality risk than phenotypes defined by exacerbation history and presence/absence of chronic bronchitis and/or asthmatic features.

Citovat

KOBLIZEK, Vladimir, Branislava MILENKOVIC, Michal SVOBODA, Jana KOCIANOVA, Stanislav HOLUB, Vladimir ZINDR, Miroslav ILIC, Jelena JANKOVIC, Vojislav CUPURDIJA, Jiří JARKOVSKÝ, Boris POPOV and Arschang VALIPOUR. RETRO-POPE: A Retrospective, Multicenter, Real-World Study of All-Cause Mortality in COPD. International Journal of chronic obstructive pulmonary disease. Albany: Dove Medical Press Ltd., 2023, vol. 18, November 2023, p. 2661-2672. ISSN 1178-2005. Available from: https://dx.doi.org/10.2147/COPD.S426919.

@article{2368111,
   author = {Koblizek, Vladimir and Milenkovic, Branislava and Svoboda, Michal and Kocianova, Jana and Holub, Stanislav and Zindr, Vladimir and Ilic, Miroslav and Jankovic, Jelena and Cupurdija, Vojislav and Jarkovský, Jiří and Popov, Boris and Valipour, Arschang},
   article_location = {Albany},
   article_number = {November 2023},
   doi = {http://dx.doi.org/10.2147/COPD.S426919},
   keywords = {COPD; survival; mortality; Central and Eastern Europe; respiratory; clinical phenotype; cluster},
   language = {eng},
   issn = {1178-2005},
   journal = {International Journal of chronic obstructive pulmonary disease},
   title = {RETRO-POPE: A Retrospective, Multicenter, Real-World Study of All-Cause Mortality in COPD},
   url = {https://www.dovepress.com/retro-pope-a-retrospective-multicenter-real-world-study-of-all-cause-m-peer-reviewed-fulltext-article-COPD},
   volume = {18},
   year = {2023}
}

TY  - JOUR
ID  - 2368111
AU  - Koblizek, Vladimir - Milenkovic, Branislava - Svoboda, Michal - Kocianova, Jana - Holub, Stanislav - Zindr, Vladimir - Ilic, Miroslav - Jankovic, Jelena - Cupurdija, Vojislav - Jarkovský, Jiří - Popov, Boris - Valipour, Arschang
PY  - 2023
TI  - RETRO-POPE: A Retrospective, Multicenter, Real-World Study of All-Cause Mortality in COPD
JF  - International Journal of chronic obstructive pulmonary disease
VL  - 18
IS  - November 2023
SP  - 2661-2672
EP  - 2661-2672
PB  - Dove Medical Press Ltd.
SN  - 11782005
KW  - COPD
KW  - survival
KW  - mortality
KW  - Central and Eastern Europe
KW  - respiratory
KW  - clinical phenotype
KW  - cluster
UR  - https://www.dovepress.com/retro-pope-a-retrospective-multicenter-real-world-study-of-all-cause-m-peer-reviewed-fulltext-article-COPD
N2  - Purpose: The Phenotypes of COPD in Central and Eastern Europe (POPE) study assessed the prevalence and clinical characteristics of four clinical COPD phenotypes, but not mortality. This retrospective analysis of the POPE study (RETRO-POPE) investigated the relationship between all-cause mortality and patient characteristics using two grouping methods: clinical phenotyping (as in POPE) and Burgel clustering, to better identify high-risk patients.Patients and Methods: The two largest POPE study patient cohorts (Czech Republic and Serbia) were categorized into one of four clinical phenotypes (acute exacerbators [with/without chronic bronchitis], non-exacerbators, asthma-COPD overlap), and one of five Burgel clusters based on comorbidities, lung function, age, body mass index (BMI) and dyspnea (very severe comorbid, very severe respiratory, moderate-to-severe respiratory, moderate-to-severe comorbid/obese, and mild respiratory). Patients were followed-up for approximately 7 years for survival status.Results: Overall, 801 of 1,003 screened patients had sufficient data for analysis. Of these, 440 patients (54.9%) were alive and 361 (45.1%) had died at the end of follow-up. Analysis of survival by clinical phenotype showed no significant differences between the phenotypes (P=0.211). However, Burgel clustering demonstrated significant differences in survival between clusters (P<0.001), with patients in the "very severe comorbid" and "very severe respiratory" clusters most likely to die. Overall survival was not significantly different between Serbia and the Czech Republic after adjustment for age, BMI, comorbidities and forced expiratory volume in 1 second (hazard ratio [HR] 0.80, 95% confidence interval [CI] 0.65-0.99; P=0.036 [unadjusted]; HR 0.88, 95% CI 0.7-1.1; P=0.257 [adjusted]). The most common causes of death were respiratory-related (36.8%), followed by cardiovascular (25.2%) then neoplasm (15.2%).Conclusion: Patient clusters based on comorbidities, lung function, age, BMI and dyspnea were more likely to show differences in COPD mortality risk than phenotypes defined by exacerbation history and presence/absence of chronic bronchitis and/or asthmatic features.
ER  -

KOBLIZEK, Vladimir, Branislava MILENKOVIC, Michal SVOBODA, Jana KOCIANOVA, Stanislav HOLUB, Vladimir ZINDR, Miroslav ILIC, Jelena JANKOVIC, Vojislav CUPURDIJA, Jiří JARKOVSKÝ, Boris POPOV and Arschang VALIPOUR. RETRO-POPE: A Retrospective, Multicenter, Real-World Study of All-Cause Mortality in COPD. \textit{International Journal of chronic obstructive pulmonary disease}. Albany: Dove Medical Press Ltd., 2023, vol.~18, November 2023, p.~2661-2672. ISSN~1178-2005. Available from: https://dx.doi.org/10.2147/COPD.S426919.

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