| WILLIEM, Ereny S., Ahmed B. M. IBRAHIM, S. ABD ELKHALIK, Jaromír MAREK and S. M. ABBAS. In vitro biological activity of cobalt(II) complexes with salicylaldimine ligands in microbial and cancer cells. Future Medicinal Chemistry. Newlands Press Ltd, 2023, vol. 15, No 15, p. 1415-1426. ISSN 1756-8919. Available from: https://dx.doi.org/10.4155/fmc-2023-0190. |
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@article{2368527,
author = {Williem, Ereny S. and Ibrahim, Ahmed B. M. and Abd Elkhalik, S. and Marek, Jaromír and Abbas, S. M.},
article_number = {15},
doi = {http://dx.doi.org/10.4155/fmc-2023-0190},
keywords = {anionic ligands; breast cells; Candida albicans; Schiff bases; Staphylococcus aureus; tetrahedral},
language = {eng},
issn = {1756-8919},
journal = {Future Medicinal Chemistry},
title = {In vitro biological activity of cobalt(II) complexes with salicylaldimine ligands in microbial and cancer cells},
url = {https://www.future-science.com/doi/full/10.4155/fmc-2023-0190},
volume = {15},
year = {2023}
}
TY - JOUR
ID - 2368527
AU - Williem, Ereny S. - Ibrahim, Ahmed B. M. - Abd Elkhalik, S. - Marek, Jaromír - Abbas, S. M.
PY - 2023
TI - In vitro biological activity of cobalt(II) complexes with salicylaldimine ligands in microbial and cancer cells
JF - Future Medicinal Chemistry
VL - 15
IS - 15
SP - 1415-1426
EP - 1415-1426
PB - Newlands Press Ltd
SN - 17568919
KW - anionic ligands
KW - breast cells
KW - Candida albicans
KW - Schiff bases
KW - Staphylococcus aureus
KW - tetrahedral
UR - https://www.future-science.com/doi/full/10.4155/fmc-2023-0190
N2 - Background: More studies using cobalt complexes as drugs are needed. Results: The drug action of two cobalt salicylaldimines was determined. The complexes and amphotericin B (20 mg/ml) inhibited Candida albicans at 9–15 and 21 mm. This concentration of both ligands inhibited Staphylococcus aureus at 10 mm and one ligand inhibited Escherichia coli at 9 mm, but the complexes and ampicillin inhibited four bacteria at 9–20 and 21–26 mm. The ligands were inactive against cancer and normal cells, but the complexes and doxorubicin provided IC50 values of 28.18–54.19 and 9.66 μM against MCF-7 cells and 15.76–20.49 and 36.42 μM against BHK cells. Conclusion: The ligands' activity was much improved by complexation, although they remained substandard.
ER -
WILLIEM, Ereny S., Ahmed B. M. IBRAHIM, S. ABD ELKHALIK, Jaromír MAREK and S. M. ABBAS. In vitro biological activity of cobalt(II) complexes with salicylaldimine ligands in microbial and cancer cells. \textit{Future Medicinal Chemistry}. Newlands Press Ltd, 2023, vol.~15, No~15, p.~1415-1426. ISSN~1756-8919. Available from: https://dx.doi.org/10.4155/fmc-2023-0190.
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