Ideal marker for targeted axillary dissection (IMTAD): a
prospective multicentre trial

J 2023

Ideal marker for targeted axillary dissection (IMTAD): a prospective multicentre trial

ZATECKY, Jan, Oldřich COUFAL, Ondřej ZAPLETAL, Otakar KUBALA, Marketa KEPICOVA et. al.

Basic information

Original name

Ideal marker for targeted axillary dissection (IMTAD): a prospective multicentre trial

Authors

ZATECKY, Jan (203 Czech Republic, guarantor), Oldřich COUFAL (203 Czech Republic), Ondřej ZAPLETAL (203 Czech Republic, belonging to the institution), Otakar KUBALA (203 Czech Republic), Marketa KEPICOVA (203 Czech Republic), Adela FARIDOVA (203 Czech Republic), Karel RAUS (203 Czech Republic), Jiri GATEK (203 Czech Republic), Peter KOSAC (203 Czech Republic) and Matus PETEJA (203 Czech Republic)

Edition

World Journal of Surgical Oncology, London, BioMed Central, 2023, 1477-7819

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30212 Surgery

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.200 in 2022

RIV identification code

RIV/00216224:14110/23:00133385

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1186/s12957-023-03147-x

UT WoS

001049914600002

Keywords in English

Targeted axillary dissection; Breast cancer; Magnetic seed; Iodine seed; Clip; Carbon suspension

Abstract

V originále

BackgroundTargeted axillary dissection (TAD) is an established method for axillary staging in patients with breast cancer after neoadjuvant chemotherapy (NAC). TAD consists of sentinel lymph node biopsy and initially pathological lymph node excision, which must be marked by a reliable marker before NAC.MethodsThe IMTAD study is a prospective multicentre trial comparing three localisation markers for lymph node localisation (clip + iodine seed, magnetic seed, carbon suspension) facilitating subsequent surgical excision in the form of TAD. The primary outcome was to prospectively compare the reliability, accuracy, and safety according to complication rate during marker implantation and detection and marker dislodgement.ResultsOne hundred eighty-nine patients were included in the study-in 135 patients clip + iodine seed was used, in 30 patients magnetic seed and in 24 patients carbon suspension. The complication rate during the marker implantation and detection were not statistically significant between individual markers (p = 0.263; p = 0.117). Marker dislodgement was reported in 4 patients with clip + iodine seed localisation (3.0%), dislodgement did not occur in other localisation methods (p = 0.999). The false-negativity of sentinel lymph node (SLN) was observed in 8 patients, the false-negativity of targeted lymph nodes (TLN) wasn & PRIME;t observed at all, the false-negativity rate (FNR) from the subcohort of ypN + patients for SLN is 9.6% and for TLN 0.0%.ConclusionThe IMTAD study indicated, that clip + iodine seed, magnetic seed and carbon suspension are statistically comparable in terms of complications during marker implantation and detection and marker dislodgement proving their safety, accuracy, and reliability in TAD. The study confirmed, that the FNR of the TLN was lower than the FNR of the SLN proving that the TLN is a better marker for axillary lymph node status after NAC.

Citovat

ZATECKY, Jan, Oldřich COUFAL, Ondřej ZAPLETAL, Otakar KUBALA, Marketa KEPICOVA, Adela FARIDOVA, Karel RAUS, Jiri GATEK, Peter KOSAC and Matus PETEJA. Ideal marker for targeted axillary dissection (IMTAD): a prospective multicentre trial. World Journal of Surgical Oncology. London: BioMed Central, 2023, vol. 21, No 1, p. 1-9. ISSN 1477-7819. Available from: https://dx.doi.org/10.1186/s12957-023-03147-x.

@article{2368680,
   author = {Zatecky, Jan and Coufal, Oldřich and Zapletal, Ondřej and Kubala, Otakar and Kepicova, Marketa and Faridova, Adela and Raus, Karel and Gatek, Jiri and Kosac, Peter and Peteja, Matus},
   article_location = {London},
   article_number = {1},
   doi = {http://dx.doi.org/10.1186/s12957-023-03147-x},
   keywords = {Targeted axillary dissection; Breast cancer; Magnetic seed; Iodine seed; Clip; Carbon suspension},
   language = {eng},
   issn = {1477-7819},
   journal = {World Journal of Surgical Oncology},
   title = {Ideal marker for targeted axillary dissection (IMTAD): a prospective multicentre trial},
   url = {https://wjso.biomedcentral.com/articles/10.1186/s12957-023-03147-x},
   volume = {21},
   year = {2023}
}

TY  - JOUR
ID  - 2368680
AU  - Zatecky, Jan - Coufal, Oldřich - Zapletal, Ondřej - Kubala, Otakar - Kepicova, Marketa - Faridova, Adela - Raus, Karel - Gatek, Jiri - Kosac, Peter - Peteja, Matus
PY  - 2023
TI  - Ideal marker for targeted axillary dissection (IMTAD): a prospective multicentre trial
JF  - World Journal of Surgical Oncology
VL  - 21
IS  - 1
SP  - 1-9
EP  - 1-9
PB  - BioMed Central
SN  - 14777819
KW  - Targeted axillary dissection
KW  - Breast cancer
KW  - Magnetic seed
KW  - Iodine seed
KW  - Clip
KW  - Carbon suspension
UR  - https://wjso.biomedcentral.com/articles/10.1186/s12957-023-03147-x
N2  - BackgroundTargeted axillary dissection (TAD) is an established method for axillary staging in patients with breast cancer after neoadjuvant chemotherapy (NAC). TAD consists of sentinel lymph node biopsy and initially pathological lymph node excision, which must be marked by a reliable marker before NAC.MethodsThe IMTAD study is a prospective multicentre trial comparing three localisation markers for lymph node localisation (clip + iodine seed, magnetic seed, carbon suspension) facilitating subsequent surgical excision in the form of TAD. The primary outcome was to prospectively compare the reliability, accuracy, and safety according to complication rate during marker implantation and detection and marker dislodgement.ResultsOne hundred eighty-nine patients were included in the study-in 135 patients clip + iodine seed was used, in 30 patients magnetic seed and in 24 patients carbon suspension. The complication rate during the marker implantation and detection were not statistically significant between individual markers (p = 0.263; p = 0.117). Marker dislodgement was reported in 4 patients with clip + iodine seed localisation (3.0%), dislodgement did not occur in other localisation methods (p = 0.999). The false-negativity of sentinel lymph node (SLN) was observed in 8 patients, the false-negativity of targeted lymph nodes (TLN) wasn & PRIME;t observed at all, the false-negativity rate (FNR) from the subcohort of ypN + patients for SLN is 9.6% and for TLN 0.0%.ConclusionThe IMTAD study indicated, that clip + iodine seed, magnetic seed and carbon suspension are statistically comparable in terms of complications during marker implantation and detection and marker dislodgement proving their safety, accuracy, and reliability in TAD. The study confirmed, that the FNR of the TLN was lower than the FNR of the SLN proving that the TLN is a better marker for axillary lymph node status after NAC.
ER  -

ZATECKY, Jan, Oldřich COUFAL, Ondřej ZAPLETAL, Otakar KUBALA, Marketa KEPICOVA, Adela FARIDOVA, Karel RAUS, Jiri GATEK, Peter KOSAC and Matus PETEJA. Ideal marker for targeted axillary dissection (IMTAD): a prospective multicentre trial. \textit{World Journal of Surgical Oncology}. London: BioMed Central, 2023, vol.~21, No~1, p.~1-9. ISSN~1477-7819. Available from: https://dx.doi.org/10.1186/s12957-023-03147-x.

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