Clinical and laboratory diversity of diffuse large B-cell
lymphomas in children with Nijmegen breakage syndrome

J 2023

Clinical and laboratory diversity of diffuse large B-cell lymphomas in children with Nijmegen breakage syndrome

PASTORCZAK, Agata, Bartosz SZMYD, Marcin BRAUN, Joanna MADZIO, Kamila WYPYSZCZAK et. al.

Basic information

Original name

Clinical and laboratory diversity of diffuse large B-cell lymphomas in children with Nijmegen breakage syndrome

Authors

PASTORCZAK, Agata (guarantor), Bartosz SZMYD, Marcin BRAUN, Joanna MADZIO, Kamila WYPYSZCZAK, Pawel SZTROMWASSER, Wojciech FENDLER, Marzena WOJTASZEWSKA, Jedrzej CHRZANOWSKI, Wieslawa GRAJKOWSKA, Hanna GREGOREK, Anna WAKULINSKA, Bernarda KAZANOWSKA, Zdenka KŘENOVÁ (203 Czech Republic, belonging to the institution), Dilys D WEIJERS, Roland P KUIPER and Wojciech MLYNARSKI

Edition

Haematologica, PAVIA, FERRATA STORTI FOUNDATION, 2023, 0390-6078

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

Italy

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 10.100 in 2022

RIV identification code

RIV/00216224:14110/23:00133398

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3324/haematol.2022.282325

UT WoS

001109389400020

Keywords in English

large B-cell lymphomas; children

Abstract

V originále

Nijmegen breakage syndrome (NBS) is an inherited DNA repair disorder characterized by a high predisposition to develop lymphoid malignancies during childhood, with diffuse large B-cell lymphoma (DLBCL) being one of the leading types. Due to concomitant immunodeficiency and an increased risk of chemotherapy-induced toxicity, NBS patients often require modified and individualized cancer treatment. Nevertheless, they rarely achieve progressionand relapse-free long-term survival rates without hematopoietic stem cell transplantation. Unfavorable outcome of lymphomas in NBS may result not only from the reduction of drug dosages but could be associated with molecular aberrations occurring on the background of chromosomal instability. Therefore, we aimed to investigate clinical outcome, histopathological features, and genomic alterations of DLBCL in pediatric patients with NBS.

Links

MUNI/A/1395/2022, interní kód MU

Name: Personalizovaná léčba v dětské onkologii: multimodální theranostický přístup a „N-of-1 clinical trials“

Investor: Masaryk University

Citovat

PASTORCZAK, Agata, Bartosz SZMYD, Marcin BRAUN, Joanna MADZIO, Kamila WYPYSZCZAK, Pawel SZTROMWASSER, Wojciech FENDLER, Marzena WOJTASZEWSKA, Jedrzej CHRZANOWSKI, Wieslawa GRAJKOWSKA, Hanna GREGOREK, Anna WAKULINSKA, Bernarda KAZANOWSKA, Zdenka KŘENOVÁ, Dilys D WEIJERS, Roland P KUIPER and Wojciech MLYNARSKI. Clinical and laboratory diversity of diffuse large B-cell lymphomas in children with Nijmegen breakage syndrome. Haematologica. PAVIA: FERRATA STORTI FOUNDATION, 2023, vol. 108, No 10, p. 2808-2813. ISSN 0390-6078. Available from: https://dx.doi.org/10.3324/haematol.2022.282325.

@article{2368922,
   author = {Pastorczak, Agata and Szmyd, Bartosz and Braun, Marcin and Madzio, Joanna and Wypyszczak, Kamila and Sztromwasser, Pawel and Fendler, Wojciech and Wojtaszewska, Marzena and Chrzanowski, Jedrzej and Grajkowska, Wieslawa and Gregorek, Hanna and Wakulinska, Anna and Kazanowska, Bernarda and Křenová, Zdenka and Weijers, Dilys D and Kuiper, Roland P and Mlynarski, Wojciech},
   article_location = {PAVIA},
   article_number = {10},
   doi = {http://dx.doi.org/10.3324/haematol.2022.282325},
   keywords = {large B-cell lymphomas; children},
   language = {eng},
   issn = {0390-6078},
   journal = {Haematologica},
   title = {Clinical and laboratory diversity of diffuse large B-cell lymphomas in children with Nijmegen breakage syndrome},
   url = {https://haematologica.org/article/view/haematol.2022.282325},
   volume = {108},
   year = {2023}
}

TY  - JOUR
ID  - 2368922
AU  - Pastorczak, Agata - Szmyd, Bartosz - Braun, Marcin - Madzio, Joanna - Wypyszczak, Kamila - Sztromwasser, Pawel - Fendler, Wojciech - Wojtaszewska, Marzena - Chrzanowski, Jedrzej - Grajkowska, Wieslawa - Gregorek, Hanna - Wakulinska, Anna - Kazanowska, Bernarda - Křenová, Zdenka - Weijers, Dilys D - Kuiper, Roland P - Mlynarski, Wojciech
PY  - 2023
TI  - Clinical and laboratory diversity of diffuse large B-cell lymphomas in children with Nijmegen breakage syndrome
JF  - Haematologica
VL  - 108
IS  - 10
SP  - 2808-2813
EP  - 2808-2813
PB  - FERRATA STORTI FOUNDATION
SN  - 03906078
KW  - large B-cell lymphomas
KW  - children
UR  - https://haematologica.org/article/view/haematol.2022.282325
N2  - Nijmegen breakage syndrome (NBS) is an inherited DNA repair disorder characterized by a high predisposition to develop lymphoid malignancies during childhood, with diffuse large B-cell lymphoma (DLBCL) being one of the leading types. Due to concomitant immunodeficiency and an increased risk of chemotherapy-induced toxicity, NBS patients often require modified and individualized cancer treatment. Nevertheless, they rarely achieve progressionand relapse-free long-term survival rates without hematopoietic stem cell transplantation. Unfavorable outcome of lymphomas in NBS may result not only from the reduction of drug dosages but could be associated with molecular aberrations occurring on the background of chromosomal instability. Therefore, we aimed to investigate clinical outcome, histopathological features, and genomic alterations of DLBCL in pediatric patients with NBS.
ER  -

PASTORCZAK, Agata, Bartosz SZMYD, Marcin BRAUN, Joanna MADZIO, Kamila WYPYSZCZAK, Pawel SZTROMWASSER, Wojciech FENDLER, Marzena WOJTASZEWSKA, Jedrzej CHRZANOWSKI, Wieslawa GRAJKOWSKA, Hanna GREGOREK, Anna WAKULINSKA, Bernarda KAZANOWSKA, Zdenka KŘENOVÁ, Dilys D WEIJERS, Roland P KUIPER and Wojciech MLYNARSKI. Clinical and laboratory diversity of diffuse large B-cell lymphomas in children with Nijmegen breakage syndrome. \textit{Haematologica}. PAVIA: FERRATA STORTI FOUNDATION, 2023, vol.~108, No~10, p.~2808-2813. ISSN~0390-6078. Available from: https://dx.doi.org/10.3324/haematol.2022.282325.

Detailed Information on Publication Record