| FERNANDES, Soraia, La Cruz Jorge OLIVER-DE, Sofia MORAZZO, Francesco NIRO, Helena DURIKOVA, Marco CASSANI, Alessio CARAVELLA, Piergiuseppe FIORE, Giulia AZZATO, De Marco GIUSEPPE, Agostino LAURIA, Valerio IZZI, Veronika BOSÁKOVÁ, Jan FRIC, Petr FILIPENSKY and Giancarlo FORTE. TGF-β induces matrisome pathological alterations and EMT in patient-derived prostate cancer tumoroids. Matrix Biology. AMSTERDAM: Elsevier, 2024, vol. 125, January 2024, p. 12-30. ISSN 0945-053X. Available from: https://dx.doi.org/10.1016/j.matbio.2023.11.001. |
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@article{2368960,
author = {Fernandes, Soraia and OliverandDe, La Cruz Jorge and Morazzo, Sofia and Niro, Francesco and Durikova, Helena and Cassani, Marco and Caravella, Alessio and Fiore, Piergiuseppe and Azzato, Giulia and Giuseppe, De Marco and Lauria, Agostino and Izzi, Valerio and Bosáková, Veronika and Fric, Jan and Filipensky, Petr and Forte, Giancarlo},
article_location = {AMSTERDAM},
article_number = {January 2024},
doi = {http://dx.doi.org/10.1016/j.matbio.2023.11.001},
keywords = {Cancer; Tumour; Extracellular matrix (ECM); Tumoroids; Prostate; Epithelial-to-mesenchymal transition (EMT); Transforming growth factor (TGF)},
language = {eng},
issn = {0945-053X},
journal = {Matrix Biology},
title = {TGF-β induces matrisome pathological alterations and EMT in patient-derived prostate cancer tumoroids},
url = {https://www.sciencedirect.com/science/article/pii/S0945053X23001130?via%3Dihub},
volume = {125},
year = {2024}
}
TY - JOUR
ID - 2368960
AU - Fernandes, Soraia - Oliver-De, La Cruz Jorge - Morazzo, Sofia - Niro, Francesco - Durikova, Helena - Cassani, Marco - Caravella, Alessio - Fiore, Piergiuseppe - Azzato, Giulia - Giuseppe, De Marco - Lauria, Agostino - Izzi, Valerio - Bosáková, Veronika - Fric, Jan - Filipensky, Petr - Forte, Giancarlo
PY - 2024
TI - TGF-β induces matrisome pathological alterations and EMT in patient-derived prostate cancer tumoroids
JF - Matrix Biology
VL - 125
IS - January 2024
SP - 12-30
EP - 12-30
PB - Elsevier
SN - 0945053X
KW - Cancer
KW - Tumour
KW - Extracellular matrix (ECM)
KW - Tumoroids
KW - Prostate
KW - Epithelial-to-mesenchymal transition (EMT)
KW - Transforming growth factor (TGF)
UR - https://www.sciencedirect.com/science/article/pii/S0945053X23001130?via%3Dihub
N2 - Extracellular matrix (ECM) tumorigenic alterations resulting in high matrix deposition and stiffening are hallmarks of adenocarcinomas and are collectively defined as desmoplasia. Here, we thoroughly analysed primary prostate cancer tissues obtained from numerous patients undergoing radical prostatectomy to highlight reproducible structural changes in the ECM leading to the loss of the glandular architecture. Starting from patient cells, we established prostate cancer tumoroids (PCTs) and demonstrated they require TGF-beta signalling pathway activity to preserve phenotypical and structural similarities with the tissue of origin. By modulating TGF-beta signalling pathway in PCTs, we unveiled its role in ECM accumulation and remodelling in prostate cancer. We also found that TGF-beta-induced ECM remodelling is responsible for the initiation of prostate cell epithelial-tomesenchymal transition (EMT) and the acquisition of a migratory, invasive phenotype. Our findings highlight the cooperative role of TGF-beta signalling and ECM desmoplasia in prompting prostate cell EMT and promoting tumour progression and dissemination.
ER -
FERNANDES, Soraia, La Cruz Jorge OLIVER-DE, Sofia MORAZZO, Francesco NIRO, Helena DURIKOVA, Marco CASSANI, Alessio CARAVELLA, Piergiuseppe FIORE, Giulia AZZATO, De Marco GIUSEPPE, Agostino LAURIA, Valerio IZZI, Veronika BOSÁKOVÁ, Jan FRIC, Petr FILIPENSKY and Giancarlo FORTE. TGF-β induces matrisome pathological alterations and EMT in patient-derived prostate cancer tumoroids. \textit{Matrix Biology}. AMSTERDAM: Elsevier, 2024, vol.~125, January 2024, p.~12-30. ISSN~0945-053X. Available from: https://dx.doi.org/10.1016/j.matbio.2023.11.001.
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