The Simulation Centre (SIMU) of the Faculty of Medicine of Masaryk University is one of the largest (covering more than 8,000 square metres in total) and the most modern simulation centres in Central Europe. SIMU represents a unique teaching complex which combines theoretical and practical education and covers a comprehensive spectrum of simulation teaching methods. Great emphasis is put on developing students’ soft skills, such as communication skills, decision-making skills, critical thinking, crisis communication and teamwork. SIMU focuses on the innovation of various medical programmes at Masaryk University by integrating advanced elements of simulation medicine into regular teaching. The SIMU team of experts provides the methodological, pedagogical and technical background for practical improvements in the General Medicine and Dentistry study programmes. The SIMU project addresses the following domains: (i) interactive clinical training, (ii) development of curriculum materials, (iii) standardisation of teaching and its continuous evaluation, (iv) implementation of objective structured clinical examination, (v) technology-enhanced learning.