Clinical Efficacy of Hyaluronic Acid with Iodine in
Hard-to-Heal Wounds

J 2023

Clinical Efficacy of Hyaluronic Acid with Iodine in Hard-to-Heal Wounds

PECOVÁ, Jana, Vladimíra ROHLÍKOVÁ, Markéta ŠMOLDASOVÁ and Jan MAREK

Basic information

Original name

Clinical Efficacy of Hyaluronic Acid with Iodine in Hard-to-Heal Wounds

Authors

PECOVÁ, Jana (203 Czech Republic, guarantor, belonging to the institution), Vladimíra ROHLÍKOVÁ (203 Czech Republic), Markéta ŠMOLDASOVÁ (203 Czech Republic) and Jan MAREK (203 Czech Republic)

Edition

PHARMACEUTICS, SWITZERLAND, MDPI, 2023, 1999-4923

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30202 Endocrinology and metabolism

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Fulltext na stránkách vydavatele

Impact factor

Impact factor: 5.400 in 2022

RIV identification code

RIV/00216224:14110/23:00133477

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3390/pharmaceutics15092268

UT WoS

001074547300001

Keywords in English

chronic wounds; ulcer; treatment; hyaluronic acid; iodine

Abstract

V originále

Hard-to-heal wounds do not heal spontaneously and need long-term care provided by specialists. That burdens the patients as well as the healthcare systems. Such wounds arise from several pathologies, which result in venous leg ulcers (VLU), diabetic foot ulcers (DFU), pressure ulcers (PU), or ulcers originating from post-surgical wounds (pSW). Given the complex nature of hard-to-heal wounds, novel treatments are sought to enable wound healing. We tested the clinical efficacy and applicability of fluid comprising hyaluronic acid and iodine complex (HA-I) in the treatment of hard-to-heal wounds. Patients (n = 56) with VLU, DFU, PU, or pSW hospitalised in multiple wound-care centres in the Czech Republic were treated with HA-I. Wound size, classically visible signs of infection, exudation, pain, and wound bed appearance were monitored for 12 weeks. The highest healing rate was in DFU (71.4%), followed by pSW (62.5%), VLU (55.6%), and PU (44.4%). Classical visible signs of infection were resolved within 8 weeks in all types of wounds. Wound bed appearance improved most noticeably in pSW and then in VLU. Exudation was lowered most significantly in DFU and pSW. The highest decrease in pain was in pSW and DFU. The treatment with HA-I successfully led to either complete closure or significant improvement in the wound’s healing. Therefore, the complex of hyaluronic acid and iodine is suitable for the treatment of hard-to-heal wounds of various aetiologies

Citovat

PECOVÁ, Jana, Vladimíra ROHLÍKOVÁ, Markéta ŠMOLDASOVÁ and Jan MAREK. Clinical Efficacy of Hyaluronic Acid with Iodine in Hard-to-Heal Wounds. PHARMACEUTICS. SWITZERLAND: MDPI, 2023, vol. 15, No 9, p. 1-12. ISSN 1999-4923. Available from: https://dx.doi.org/10.3390/pharmaceutics15092268.

@article{2370984,
   author = {Pecová, Jana and Rohlíková, Vladimíra and Šmoldasová, Markéta and Marek, Jan},
   article_location = {SWITZERLAND},
   article_number = {9},
   doi = {http://dx.doi.org/10.3390/pharmaceutics15092268},
   keywords = {chronic wounds; ulcer; treatment; hyaluronic acid; iodine},
   language = {eng},
   issn = {1999-4923},
   journal = {PHARMACEUTICS},
   title = {Clinical Efficacy of Hyaluronic Acid with Iodine in Hard-to-Heal Wounds},
   url = {https://www.mdpi.com/1999-4923/15/9/2268},
   volume = {15},
   year = {2023}
}

TY  - JOUR
ID  - 2370984
AU  - Pecová, Jana - Rohlíková, Vladimíra - Šmoldasová, Markéta - Marek, Jan
PY  - 2023
TI  - Clinical Efficacy of Hyaluronic Acid with Iodine in Hard-to-Heal Wounds
JF  - PHARMACEUTICS
VL  - 15
IS  - 9
SP  - 1-12
EP  - 1-12
PB  - MDPI
SN  - 19994923
KW  - chronic wounds
KW  - ulcer
KW  - treatment
KW  - hyaluronic acid
KW  - iodine
UR  - https://www.mdpi.com/1999-4923/15/9/2268
N2  - Hard-to-heal wounds do not heal spontaneously and need long-term care provided by specialists. That burdens the patients as well as the healthcare systems. Such wounds arise from several pathologies, which result in venous leg ulcers (VLU), diabetic foot ulcers (DFU), pressure ulcers (PU), or ulcers originating from post-surgical wounds (pSW). Given the complex nature of hard-to-heal wounds, novel treatments are sought to enable wound healing. We tested the clinical efficacy and applicability of fluid comprising hyaluronic acid and iodine complex (HA-I) in the treatment of hard-to-heal wounds. Patients (n = 56) with VLU, DFU, PU, or pSW hospitalised in multiple wound-care centres in the Czech Republic were treated with HA-I. Wound size, classically visible signs of infection, exudation, pain, and wound bed appearance were monitored for 12 weeks. The highest healing rate was in DFU (71.4%), followed by pSW (62.5%), VLU (55.6%), and PU (44.4%). Classical visible signs of infection were resolved within 8 weeks in all types of wounds. Wound bed appearance improved most noticeably in pSW and then in VLU. Exudation was lowered most significantly in DFU and pSW. The highest decrease in pain was in pSW and DFU. The treatment with HA-I successfully led to either complete closure or significant improvement in the wound’s healing. Therefore, the complex of hyaluronic acid and iodine is suitable for the treatment of hard-to-heal wounds of various aetiologies
ER  -

PECOVÁ, Jana, Vladimíra ROHLÍKOVÁ, Markéta ŠMOLDASOVÁ and Jan MAREK. Clinical Efficacy of Hyaluronic Acid with Iodine in Hard-to-Heal Wounds. \textit{PHARMACEUTICS}. SWITZERLAND: MDPI, 2023, vol.~15, No~9, p.~1-12. ISSN~1999-4923. Available from: https://dx.doi.org/10.3390/pharmaceutics15092268.

Detailed Information on Publication Record