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@article{2371178,
author = {Salon, Adam and Ciftci, Goektug Mert and Zubac, Damir and Simunic, Bostjan and Pisot, Rado and Narici, Marco and Fredriksen, Per Morten and NkehandChungag, Benedicta Ngwenchi and Sourij, Harald and Šerý, Omar and SchmidandZalaudek, Karin and Steuber, Bianca and Patrick, De Boever and Goswami, Nandu},
article_location = {Berlin},
article_number = {1},
doi = {http://dx.doi.org/10.1038/s41598-023-46177-x},
keywords = {BAROREFLEX CONTROL; PLASMA-VOLUME; BLOOD-FLOW; RISK; MICROGRAVITY; HYPERTENSION; RESPONSES; ATROPHY},
language = {eng},
issn = {2045-2322},
journal = {Nature Scientific Reports},
title = {Retinal venular vessel diameters are smaller during ten days of bed rest},
url = {https://www.nature.com/articles/s41598-023-46177-x},
volume = {13},
year = {2023}
}
TY - JOUR
ID - 2371178
AU - Salon, Adam - Ciftci, Goektug Mert - Zubac, Damir - Simunic, Bostjan - Pisot, Rado - Narici, Marco - Fredriksen, Per Morten - Nkeh-Chungag, Benedicta Ngwenchi - Sourij, Harald - Šerý, Omar - Schmid-Zalaudek, Karin - Steuber, Bianca - Patrick, De Boever - Goswami, Nandu
PY - 2023
TI - Retinal venular vessel diameters are smaller during ten days of bed rest
JF - Nature Scientific Reports
VL - 13
IS - 1
SP - 1-7
EP - 1-7
PB - Nature Research
SN - 20452322
KW - BAROREFLEX CONTROL
KW - PLASMA-VOLUME
KW - BLOOD-FLOW
KW - RISK
KW - MICROGRAVITY
KW - HYPERTENSION
KW - RESPONSES
KW - ATROPHY
UR - https://www.nature.com/articles/s41598-023-46177-x
N2 - Older individuals experience cardiovascular dysfunction during extended bedridden hospital or care home stays. Bed rest is also used as a model to simulate accelerated vascular deconditioning occurring during spaceflight. This study investigates changes in retinal microcirculation during a ten-day bed rest protocol. Ten healthy young males (22.9 ± 4.7 years; body mass index: 23.6 ± 2.5 kg·m–2) participated in a strictly controlled repeated-measures bed rest study lasting ten days. High-resolution images were obtained using a hand-held fundus camera at baseline, daily during the 10 days of bed rest, and 1 day after re-ambulation. Retinal vessel analysis was performed using a semi-automated software system to obtain metrics for retinal arteriolar and venular diameters, central retinal artery equivalent and central retinal vein equivalent, respectively. Data analysis employed a mixed linear model. At the end of the bed rest period, a significant decrease in retinal venular diameter was observed, indicated by a significantly lower central retinal vein equivalent (from 226.1 µm, CI 8.90, to 211.4 µm, CI 8.28, p = .026), while no significant changes in central retinal artery equivalent were noted. Prolonged bed rest confinement resulted in a significant (up to 6.5%) reduction in retinal venular diameter. These findings suggest that the changes in retinal venular diameter during bedrest may be attributed to plasma volume losses and reflect overall (cardio)-vascular deconditioning.
ER -
SALON, Adam, Goektug Mert CIFTCI, Damir ZUBAC, Bostjan SIMUNIC, Rado PISOT, Marco NARICI, Per Morten FREDRIKSEN, Benedicta Ngwenchi NKEH-CHUNGAG, Harald SOURIJ, Omar ŠERÝ, Karin SCHMID-ZALAUDEK, Bianca STEUBER, De Boever PATRICK a Nandu GOSWAMI. Retinal venular vessel diameters are smaller during ten days of bed rest. \textit{Nature Scientific Reports}. Berlin: Nature Research, 2023, roč.~13, č.~1, s.~1-7. ISSN~2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-023-46177-x.
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