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@article{2372277,
author = {Negi, Deepika and Granak, Simon and Shorter, Susan and Leary, Valerie B and Rektor, Ivan and Ovsepian, Saak V},
article_location = {UNITED STATES},
article_number = {3},
doi = {http://dx.doi.org/10.1007/s13311-023-01355-7},
keywords = {Epileptic seizures; Neurodegeneration; Fluid biomarkers; Neurofilament light chain; Tau protein; Axonal degeneration; Neurogranin},
language = {eng},
issn = {1933-7213},
journal = {NEUROTHERAPEUTICS},
title = {Molecular Biomarkers of Neuronal Injury in Epilepsy Shared with Neurodegenerative Diseases},
url = {https://www.sciencedirect.com/science/article/pii/S1878747923000156?via%3Dihub},
volume = {20},
year = {2023}
}
TY - JOUR
ID - 2372277
AU - Negi, Deepika - Granak, Simon - Shorter, Susan - Leary, Valerie B - Rektor, Ivan - Ovsepian, Saak V
PY - 2023
TI - Molecular Biomarkers of Neuronal Injury in Epilepsy Shared with Neurodegenerative Diseases
JF - NEUROTHERAPEUTICS
VL - 20
IS - 3
SP - 767-778
EP - 767-778
PB - SPRINGER
SN - 19337213
KW - Epileptic seizures
KW - Neurodegeneration
KW - Fluid biomarkers
KW - Neurofilament light chain
KW - Tau protein
KW - Axonal degeneration
KW - Neurogranin
UR - https://www.sciencedirect.com/science/article/pii/S1878747923000156?via%3Dihub
N2 - In neurodegenerative diseases, changes in neuronal proteins in the cerebrospinal fluid and blood are viewed as potential biomarkers of the primary pathology in the central nervous system (CNS). Recent reports suggest, however, that level of neuronal proteins in fluids also alters in several types of epilepsy in various age groups, including children. With increasing evidence supporting clinical and sub-clinical seizures in Alzheimer's disease, Lewy body dementia, Parkinson's disease, and in other less common neurodegenerative conditions, these findings call into question the specificity of neuronal protein response to neurodegenerative process and urge analysis of the effects of concomitant epilepsy and other comorbidities. In this article, we revisit the evidence for alterations in neuronal proteins in the blood and cerebrospinal fluid associated with epilepsy with and without neurodegenerative diseases. We discuss shared and distinctive characteristics of changes in neuronal markers, review their neurobiological mechanisms, and consider the emerging opportunities and challenges for their future research and diagnostic use.
ER -
NEGI, Deepika, Simon GRANAK, Susan SHORTER, Valerie B LEARY, Ivan REKTOR and Saak V OVSEPIAN. Molecular Biomarkers of Neuronal Injury in Epilepsy Shared with Neurodegenerative Diseases. \textit{NEUROTHERAPEUTICS}. UNITED STATES: SPRINGER, 2023, vol.~20, No~3, p.~767-778. ISSN~1933-7213. Available from: https://dx.doi.org/10.1007/s13311-023-01355-7.
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