Structural conservation of antibiotic interaction with
ribosomes

J 2023

Structural conservation of antibiotic interaction with ribosomes

PATERNOGA, Helge, Caillan CROWE-MCAULIFFE, Lars V BOCK, Timm O KOLLER, Martino MORICI et. al.

Basic information

Original name

Structural conservation of antibiotic interaction with ribosomes

Authors

PATERNOGA, Helge, Caillan CROWE-MCAULIFFE, Lars V BOCK, Timm O KOLLER, Martino MORICI, Bertrand BECKERT, Alexander G MYASNIKOV, Helmut GRUBMUELLER, Jiří NOVÁČEK (203 Czech Republic, belonging to the institution) and Daniel N WILSON (guarantor)

Edition

NATURE STRUCTURAL & MOLECULAR BIOLOGY, NEW YORK, NATURE PUBLISHING GROUP, 2023, 1545-9993

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10608 Biochemistry and molecular biology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 16.800 in 2022

RIV identification code

RIV/00216224:14740/23:00133510

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1038/s41594-023-01047-y

UT WoS

001043691200001

Keywords in English

ribosome; antibiotics; CryoEM; antibiotic–ribosome interactions; RNA-targeting therapies

Abstract

V originále

Here the authors present the high-resolution structures of 17 antibiotics bound to Escherichia coli ribosomes, which may inform the development of new antibacterial agents. Their results unveil a conserved manner of antibiotic binding to the ribosome, including ordered water molecules.

Links

EF18_046/0015974, research and development project

Name: Modernizace České infrastruktury pro integrativní strukturní biologii

LM2023042, research and development project

Name: Česká infrastruktura pro integrativní strukturní biologii

Investor: Ministry of Education, Youth and Sports of the CR, CIISB - Czech Infrastructure for Integrative Structural Biology

871037, interní kód MU

Name: iNEXT-Discovery: Infrastructure for transnational access and discovery in integrated structural biology (Acronym: iNEXT- Discovery)

Investor: European Union, RI Research Infrastructures (Excellent Science)

Citovat

PATERNOGA, Helge, Caillan CROWE-MCAULIFFE, Lars V BOCK, Timm O KOLLER, Martino MORICI, Bertrand BECKERT, Alexander G MYASNIKOV, Helmut GRUBMUELLER, Jiří NOVÁČEK and Daniel N WILSON. Structural conservation of antibiotic interaction with ribosomes. NATURE STRUCTURAL & MOLECULAR BIOLOGY. NEW YORK: NATURE PUBLISHING GROUP, 2023, vol. 30, No 9, p. 1380-1414. ISSN 1545-9993. Available from: https://dx.doi.org/10.1038/s41594-023-01047-y.

@article{2372337,
   author = {Paternoga, Helge and CroweandMcAuliffe, Caillan and Bock, Lars V and Koller, Timm O and Morici, Martino and Beckert, Bertrand and Myasnikov, Alexander G and Grubmueller, Helmut and Nováček, Jiří and Wilson, Daniel N},
   article_location = {NEW YORK},
   article_number = {9},
   doi = {http://dx.doi.org/10.1038/s41594-023-01047-y},
   keywords = {ribosome; antibiotics; CryoEM; antibiotic–ribosome interactions; RNA-targeting therapies},
   language = {eng},
   issn = {1545-9993},
   journal = {NATURE STRUCTURAL & MOLECULAR BIOLOGY},
   title = {Structural conservation of antibiotic interaction with ribosomes},
   url = {https://www.nature.com/articles/s41594-023-01047-y},
   volume = {30},
   year = {2023}
}

TY  - JOUR
ID  - 2372337
AU  - Paternoga, Helge - Crowe-McAuliffe, Caillan - Bock, Lars V - Koller, Timm O - Morici, Martino - Beckert, Bertrand - Myasnikov, Alexander G - Grubmueller, Helmut - Nováček, Jiří - Wilson, Daniel N
PY  - 2023
TI  - Structural conservation of antibiotic interaction with ribosomes
JF  - NATURE STRUCTURAL & MOLECULAR BIOLOGY
VL  - 30
IS  - 9
SP  - 1380-1414
EP  - 1380-1414
PB  - NATURE PUBLISHING GROUP
SN  - 15459993
KW  - ribosome
KW  - antibiotics
KW  - CryoEM
KW  - antibiotic–ribosome interactions
KW  - RNA-targeting therapies
UR  - https://www.nature.com/articles/s41594-023-01047-y
N2  - Here the authors present the high-resolution structures of 17 antibiotics bound to Escherichia coli ribosomes, which may inform the development of new antibacterial agents. Their results unveil a conserved manner of antibiotic binding to the ribosome, including ordered water molecules.
ER  -

PATERNOGA, Helge, Caillan CROWE-MCAULIFFE, Lars V BOCK, Timm O KOLLER, Martino MORICI, Bertrand BECKERT, Alexander G MYASNIKOV, Helmut GRUBMUELLER, Jiří NOVÁČEK and Daniel N WILSON. Structural conservation of antibiotic interaction with ribosomes. \textit{NATURE STRUCTURAL \&{}amp; MOLECULAR BIOLOGY}. NEW YORK: NATURE PUBLISHING GROUP, 2023, vol.~30, No~9, p.~1380-1414. ISSN~1545-9993. Available from: https://dx.doi.org/10.1038/s41594-023-01047-y.

Detailed Information on Publication Record