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@article{2372479,
author = {Belbasi, Zeynab and Petr, Jan and Ševčík, Juraj and Jirovsky, David and Hrbáč, Jan},
article_location = {WASHINGTON},
article_number = {4},
doi = {http://dx.doi.org/10.1021/acsomega.3c09474},
keywords = {Carbon fiber; Electrodes; High-performance liquid chromatography; Metal oxide nanoparticles; Modification},
language = {eng},
issn = {2470-1343},
journal = {ACS Omega},
title = {Electrochemical HPLC Determination of Piperazine Antihistamine Drugs Employing a Spark-Generated Nickel Oxide Nanoparticle-Modified Carbon Fiber Microelectrode},
url = {https://pubs.acs.org/doi/10.1021/acsomega.3c09474},
volume = {9},
year = {2024}
}
TY - JOUR
ID - 2372479
AU - Belbasi, Zeynab - Petr, Jan - Ševčík, Juraj - Jirovsky, David - Hrbáč, Jan
PY - 2024
TI - Electrochemical HPLC Determination of Piperazine Antihistamine Drugs Employing a Spark-Generated Nickel Oxide Nanoparticle-Modified Carbon Fiber Microelectrode
JF - ACS Omega
VL - 9
IS - 4
SP - 5038-5045
EP - 5038-5045
PB - American Chemical Society
SN - 24701343
KW - Carbon fiber
KW - Electrodes
KW - High-performance liquid chromatography
KW - Metal oxide nanoparticles
KW - Modification
UR - https://pubs.acs.org/doi/10.1021/acsomega.3c09474
N2 - In this work, we demonstrate a sensitive high-performance liquid chromatography (HPLC) method for the determination of piperazine antihistamine drugs employing innovative electrochemical detection based on a spark-generated nickel oxide nanoparticle-modified carbon fiber microelectrode built into a miniaturized electrochemical detector. The direct carbon fiber-to-nickel plate electrode spark discharge, carried at 0.8 kV DC, with the nickel electrode connected to the negative pole of the high-voltage power supply, provides extremely fast (1 s) in situ tailoring of the carbon fiber microelectrode surface by nickel oxide nanoparticles. It has been found that nickel oxide nanoparticles exhibit an electrocatalytic effect toward the piperazine moiety electrooxidation process, as confirmed by voltammetric experiments, revealing the shift in the peak potential from 1.25 to 1.09 V versus Ag/AgCl. Cetirizine, cyclizine, chlorcyclizine, flunarizine, meclizine, and buclizine were selected as sample piperazine antihistamine drugs, while diclofenac served as an internal standard. The isocratic reversed-phase separation of the above set was achieved within 15 min using an ARION-CN 3 mu m column with a binary mobile phase consisting of 50 mM phosphate buffer (pH 3) and methanol (45/55, v/v). The limits of detection (LOD) were within the range of 3.8-120 nM (for cyclizine and buclizine) at E = +1500 mV (vs Ag/AgCl), while the response was linear within the concentration range measured up to 5 mu mol L-1. The method was successfully applied to the determination of piperazine antihistamine drugs in spiked plasma samples.
ER -
BELBASI, Zeynab, Jan PETR, Juraj ŠEVČÍK, David JIROVSKY and Jan HRBÁČ. Electrochemical HPLC Determination of Piperazine Antihistamine Drugs Employing a Spark-Generated Nickel Oxide Nanoparticle-Modified Carbon Fiber Microelectrode. \textit{ACS Omega}. WASHINGTON: American Chemical Society, 2024, vol.~9, No~4, p.~5038-5045. ISSN~2470-1343. Available from: https://dx.doi.org/10.1021/acsomega.3c09474.
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