Decellularization of lung to yield three-dimensional scaffold for pulmonary tissue engineering

ČIMBOROVÁ, Katarína, Vendula PELKOVÁ, Hana KOTASOVÁ, Veronika SEDLÁKOVÁ and Aleš HAMPL. Decellularization of lung to yield three-dimensional scaffold for pulmonary tissue engineering. In BIOCEV Regeneration III, 2023. 2023.

Basic information

Original name

Decellularization of lung to yield three-dimensional scaffold for pulmonary tissue engineering

Name (in English)

Decellularization of lung to yield three-dimensional scaffold for pulmonary tissue engineering

Authors

ČIMBOROVÁ, Katarína, Vendula PELKOVÁ, Hana KOTASOVÁ, Veronika SEDLÁKOVÁ and Aleš HAMPL

Edition

BIOCEV Regeneration III, 2023, 2023

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Other information

Type of outcome

Konferenční abstrakt

Confidentiality degree

není předmětem státního či obchodního tajemství

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International impact

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Abstract

V originále

The structural and physiological features of the lungs make the success of engineering an artificial lung model in vitro a challenge. From a slew of approaches utilized in pulmonary tissue engineering, this work focuses on the detergent-based decellularization method for obtaining a well-preserved human, pig, and mouse lung tissue scaffold. Decellularization is a method based on removing cells and the entire genetic material from a preexisting organ or tissue while preserving the composition, 3D microarchitecture, and biochemical and biophysical properties of the pulmonary tissue. These scaffolds may serve as in vitro near-to-native 3D pulmonary models, hydrogels, or bio-inks for 3D printing which hold a valuable opportunity for disease modeling, drug testing, and regeneration.