ČIMBOROVÁ, Katarína, Vendula PELKOVÁ, Hana KOTASOVÁ, Veronika SEDLÁKOVÁ and Aleš HAMPL. Decellularization of lung to yield three-dimensional scaffold for pulmonary tissue engineering. In BIOCEV Regeneration III, 2023. 2023.
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Basic information
Original name Decellularization of lung to yield three-dimensional scaffold for pulmonary tissue engineering
Name (in English) Decellularization of lung to yield three-dimensional scaffold for pulmonary tissue engineering
Authors ČIMBOROVÁ, Katarína, Vendula PELKOVÁ, Hana KOTASOVÁ, Veronika SEDLÁKOVÁ and Aleš HAMPL.
Edition BIOCEV Regeneration III, 2023, 2023.
Other information
Type of outcome Conference abstract
Confidentiality degree is not subject to a state or trade secret
WWW URL
Tags International impact
Changed by Changed by: Mgr. Katarína Čimborová, učo 474481. Changed: 12/2/2024 15:33.
Abstract
The structural and physiological features of the lungs make the success of engineering an artificial lung model in vitro a challenge. From a slew of approaches utilized in pulmonary tissue engineering, this work focuses on the detergent-based decellularization method for obtaining a well-preserved human, pig, and mouse lung tissue scaffold. Decellularization is a method based on removing cells and the entire genetic material from a preexisting organ or tissue while preserving the composition, 3D microarchitecture, and biochemical and biophysical properties of the pulmonary tissue. These scaffolds may serve as in vitro near-to-native 3D pulmonary models, hydrogels, or bio-inks for 3D printing which hold a valuable opportunity for disease modeling, drug testing, and regeneration.
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