Screening for dysphagia in patients with relapsing-remitting
multiple sclerosis

J 2024

Screening for dysphagia in patients with relapsing-remitting multiple sclerosis

KOČICA, Jan, Naděžda LASOTOVÁ, Jan KOLČAVA, Monika SVOBODOVÁ, Magdaléna HLADÍKOVÁ et. al.

Basic information

Original name

Screening for dysphagia in patients with relapsing-remitting multiple sclerosis

Name in Czech

Skríning poruch polykání u pacientů s relaps remitentní roztroušenou sklerózou

Authors

KOČICA, Jan (203 Czech Republic, belonging to the institution), Naděžda LASOTOVÁ (203 Czech Republic, belonging to the institution), Jan KOLČAVA (203 Czech Republic, belonging to the institution), Monika SVOBODOVÁ (203 Czech Republic, belonging to the institution), Magdaléna HLADÍKOVÁ (203 Czech Republic, belonging to the institution), Pavel ŠTOURAČ (203 Czech Republic, belonging to the institution), Josef BEDNAŘÍK (203 Czech Republic, belonging to the institution) and Eva VLČKOVÁ (203 Czech Republic, belonging to the institution)

Edition

Multiple Sclerosis and Related Disorders, London, ELSEVIER SCI LTD, 2024, 2211-0348

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.000 in 2022

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.msard.2023.105418

UT WoS

001176891300001

Keywords in English

Multiple sclerosis; Dysphagia; Patient reported outcome measures; Questionnaire; Deglutition

Abstract

V originále

Background: In multiple sclerosis (MS), dysphagia is an important and common clinical symptom. Although often overlooked and underdiagnosed, it can have a significant impact on a patient's life, including social integration, and it can lead to malnutrition, aspiration pneumonia, and suffocation, i.e., life -threatening complications. Early detection of dysphagia is essential to prevent these risks. However, the optimal screening method and the interrelationship between different methods used for dysphagia screening are not clear. The aim of this study was to compare the diagnostic performance of a simple question about swallowing problems, the DYsphagia in MUltiple Sclerosis (DYMUS) swallowing questionnaire, and the Timed Water Swallowing Test (TWST) to detect dysphagia in people with relapsing -remitting MS (RRMS). Methods: Patients with MS were asked about subjective swallowing difficulties and, regardless of their response, completed the DYMUS questionnaire and underwent the TWST at their routine follow-up visit. Patients with at least one positive screening method were offered an objective assessment of swallowing function using the Fiberoptic Endoscopic Evaluation of Swallowing (FEES). The results were statistically analyzed and correlated with demographic and MS -related parameters. Results: Of the 304 people with RRMS enrolled in the study, 46 (15.1 %) reported having subjective difficulty swallowing when asked a simple question. The DYMUS questionnaire was positive in 59 (19.4 %) of the 304 patients; 51 (16.8 %) had an abnormality on the TWST. A clear correlation (r = 0.351, p < 0.01) was found between the DYMUS and TWST results, but a significant proportion of patients (about half) had an abnormality on only one of these tests. The positivity of at least one of the screening methods used (DYMUS or TWST) had a better chance of identifying a patient with dysphagia than a simple question (p < 0.001). Of the patients with a positive result for difficulty swallowing, 37 underwent FEES, which confirmed dysphagia in 94.6% of this subgroup. Patients with higher Expanded Disability Status Scale (EDSS) scores, female gender, and older age were at higher risk of developing dysphagia. Conclusion: The DYMUS questionnaire and TWST had a confirmed potential to identify more patients with dysphagia than a simple question about swallowing problems. However, our study found only a partial overlap between DYMUS and TWST; a combination of these two methods was more sensitive in identifying patients with MS at risk of dysphagia. Furthermore, the screening showed excellent specificity: almost 95 % of the positively screened patients had dysphagia confirmed by objective methods. Age, female gender, and a higher EDSS score appear to be potential risk factors for dysphagia in patients with MS.

Links

MUNI/A/1186/2022, interní kód MU

Name: Diagnostika a patofyziologie neuropatické bolesti a dalších symptomů a komorbidit neurologických onemocnění

Investor: Masaryk University

Citovat

KOČICA, Jan, Naděžda LASOTOVÁ, Jan KOLČAVA, Monika SVOBODOVÁ, Magdaléna HLADÍKOVÁ, Pavel ŠTOURAČ, Josef BEDNAŘÍK and Eva VLČKOVÁ. Screening for dysphagia in patients with relapsing-remitting multiple sclerosis. Multiple Sclerosis and Related Disorders. London: ELSEVIER SCI LTD, 2024, vol. 83, March 2024, p. 1-7. ISSN 2211-0348. Available from: https://dx.doi.org/10.1016/j.msard.2023.105418.

@article{2373737,
   author = {Kočica, Jan and Lasotová, Naděžda and Kolčava, Jan and Svobodová, Monika and Hladíková, Magdaléna and Štourač, Pavel and Bednařík, Josef and Vlčková, Eva},
   article_location = {London},
   article_number = {March 2024},
   doi = {http://dx.doi.org/10.1016/j.msard.2023.105418},
   keywords = {Multiple sclerosis; Dysphagia; Patient reported outcome measures; Questionnaire; Deglutition},
   language = {eng},
   issn = {2211-0348},
   journal = {Multiple Sclerosis and Related Disorders},
   title = {Screening for dysphagia in patients with relapsing-remitting multiple sclerosis},
   url = {https://www.sciencedirect.com/science/article/pii/S2211034823009173?via%3Dihub},
   volume = {83},
   year = {2024}
}

TY  - JOUR
ID  - 2373737
AU  - Kočica, Jan - Lasotová, Naděžda - Kolčava, Jan - Svobodová, Monika - Hladíková, Magdaléna - Štourač, Pavel - Bednařík, Josef - Vlčková, Eva
PY  - 2024
TI  - Screening for dysphagia in patients with relapsing-remitting multiple sclerosis
JF  - Multiple Sclerosis and Related Disorders
VL  - 83
IS  - March 2024
SP  - 1-7
EP  - 1-7
PB  - ELSEVIER SCI LTD
SN  - 22110348
KW  - Multiple sclerosis
KW  - Dysphagia
KW  - Patient reported outcome measures
KW  - Questionnaire
KW  - Deglutition
UR  - https://www.sciencedirect.com/science/article/pii/S2211034823009173?via%3Dihub
N2  - Background: In multiple sclerosis (MS), dysphagia is an important and common clinical symptom. Although often overlooked and underdiagnosed, it can have a significant impact on a patient's life, including social integration, and it can lead to malnutrition, aspiration pneumonia, and suffocation, i.e., life -threatening complications. Early detection of dysphagia is essential to prevent these risks. However, the optimal screening method and the interrelationship between different methods used for dysphagia screening are not clear. The aim of this study was to compare the diagnostic performance of a simple question about swallowing problems, the DYsphagia in MUltiple Sclerosis (DYMUS) swallowing questionnaire, and the Timed Water Swallowing Test (TWST) to detect dysphagia in people with relapsing -remitting MS (RRMS). Methods: Patients with MS were asked about subjective swallowing difficulties and, regardless of their response, completed the DYMUS questionnaire and underwent the TWST at their routine follow-up visit. Patients with at least one positive screening method were offered an objective assessment of swallowing function using the Fiberoptic Endoscopic Evaluation of Swallowing (FEES). The results were statistically analyzed and correlated with demographic and MS -related parameters. Results: Of the 304 people with RRMS enrolled in the study, 46 (15.1 %) reported having subjective difficulty swallowing when asked a simple question. The DYMUS questionnaire was positive in 59 (19.4 %) of the 304 patients; 51 (16.8 %) had an abnormality on the TWST. A clear correlation (r = 0.351, p < 0.01) was found between the DYMUS and TWST results, but a significant proportion of patients (about half) had an abnormality on only one of these tests. The positivity of at least one of the screening methods used (DYMUS or TWST) had a better chance of identifying a patient with dysphagia than a simple question (p < 0.001). Of the patients with a positive result for difficulty swallowing, 37 underwent FEES, which confirmed dysphagia in 94.6% of this subgroup. Patients with higher Expanded Disability Status Scale (EDSS) scores, female gender, and older age were at higher risk of developing dysphagia. Conclusion: The DYMUS questionnaire and TWST had a confirmed potential to identify more patients with dysphagia than a simple question about swallowing problems. However, our study found only a partial overlap between DYMUS and TWST; a combination of these two methods was more sensitive in identifying patients with MS at risk of dysphagia. Furthermore, the screening showed excellent specificity: almost 95 % of the positively screened patients had dysphagia confirmed by objective methods. Age, female gender, and a higher EDSS score appear to be potential risk factors for dysphagia in patients with MS.
ER  -

KOČICA, Jan, Naděžda LASOTOVÁ, Jan KOLČAVA, Monika SVOBODOVÁ, Magdaléna HLADÍKOVÁ, Pavel ŠTOURAČ, Josef BEDNAŘÍK and Eva VLČKOVÁ. Screening for dysphagia in patients with relapsing-remitting multiple sclerosis. \textit{Multiple Sclerosis and Related Disorders}. London: ELSEVIER SCI LTD, 2024, vol.~83, March 2024, p.~1-7. ISSN~2211-0348. Available from: https://dx.doi.org/10.1016/j.msard.2023.105418.

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