Decreased quality of life in Duchenne muscular disease patients
related to functional neurological and cardiac impairment

J 2024

Decreased quality of life in Duchenne muscular disease patients related to functional neurological and cardiac impairment

JUŘÍKOVÁ, Lenka, Lucia MASÁROVÁ, Roman PANOVSKÝ, Martin PEŠL, Kamila ŽONDRA REVENDOVÁ et. al.

Basic information

Original name

Decreased quality of life in Duchenne muscular disease patients related to functional neurological and cardiac impairment

Authors

JUŘÍKOVÁ, Lenka (203 Czech Republic, belonging to the institution), Lucia MASÁROVÁ (703 Slovakia, belonging to the institution), Roman PANOVSKÝ (203 Czech Republic, belonging to the institution), Martin PEŠL (203 Czech Republic, belonging to the institution), Kamila ŽONDRA REVENDOVÁ (203 Czech Republic), Ondřej VOLNÝ (203 Czech Republic, belonging to the institution), Věra FEITOVÁ (203 Czech Republic, belonging to the institution), Tomáš HOLEČEK (203 Czech Republic, belonging to the institution), Vladimír KINCL (203 Czech Republic, belonging to the institution), Pavlína DANHOFER (203 Czech Republic, belonging to the institution), Stanislav VOHÁŇKA (203 Czech Republic, belonging to the institution), Jana HABERLOVÁ (203 Czech Republic) and Podolská KAROLÍNA (203 Czech Republic)

Edition

Frontiers in Neurology, LAUSANNE, FRONTIERS MEDIA SA, 2024, 1664-2295

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.400 in 2022

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3389/fneur.2024.1360385

UT WoS

001169112400001

Keywords in English

quality of life; Duchenne muscular dystrophy; cardiac magnetic resonance; neurological status; cardiac impairment

Abstract

V originále

In this prospective study involving 37 Duchenne muscular dystrophy (DMD) patients aged 8–18 years and older, we examined the impact of neurological and cardiac factors on quality of life (QoL). Our findings revealed a negative correlation between upper limb movement and overall mobility, self-service, and usual activities. Ambulatory and non-ambulatory DMD patients showed significant differences in mobility-related parameters. Cardiac evaluations demonstrated associations between mitral annular plane systolic excursion (MAPSE) and mobility-related aspects. The PEDSQL 3.0 neuromuscular model questionnaire further highlighted age-related and movement-related correlations with QoL. The loss of ambulatory status and reduced upper limb movement were negatively associated with QoL, while upper limb movement positively correlated with septal MAPSE. However, no significant associations were found between MAPSE and anxiety/depression. These findings underscore the multifaceted impact of DMD on QoL and emphasize the importance of considering both neurological and cardiac factors in comprehensive patient care.

Links

MUNI/A/1624/2023, interní kód MU

Name: Srdeční selhání, jeho komorbidity a etiologické příčiny

Investor: Masaryk University, Heart failure, its comorbidities and etiological causes

Citovat

JUŘÍKOVÁ, Lenka, Lucia MASÁROVÁ, Roman PANOVSKÝ, Martin PEŠL, Kamila ŽONDRA REVENDOVÁ, Ondřej VOLNÝ, Věra FEITOVÁ, Tomáš HOLEČEK, Vladimír KINCL, Pavlína DANHOFER, Stanislav VOHÁŇKA, Jana HABERLOVÁ and Podolská KAROLÍNA. Decreased quality of life in Duchenne muscular disease patients related to functional neurological and cardiac impairment. Frontiers in Neurology. LAUSANNE: FRONTIERS MEDIA SA, 2024, vol. 15, February 2024, p. 1-11. ISSN 1664-2295. Available from: https://dx.doi.org/10.3389/fneur.2024.1360385.

@article{2374257,
   author = {Juříková, Lenka and Masárová, Lucia and Panovský, Roman and Pešl, Martin and Žondra Revendová, Kamila and Volný, Ondřej and Feitová, Věra and Holeček, Tomáš and Kincl, Vladimír and Danhofer, Pavlína and Voháňka, Stanislav and Haberlová, Jana and Karolína, Podolská},
   article_location = {LAUSANNE},
   article_number = {February 2024},
   doi = {http://dx.doi.org/10.3389/fneur.2024.1360385},
   keywords = {quality of life; Duchenne muscular dystrophy; cardiac magnetic resonance; neurological status; cardiac impairment},
   language = {eng},
   issn = {1664-2295},
   journal = {Frontiers in Neurology},
   title = {Decreased quality of life in Duchenne muscular disease patients related to functional neurological and cardiac impairment},
   url = {https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1360385/full?utm_source=F-NTF&utm_medium=EMLX&utm_campaign=PRD_FEOPS_20170000_ARTICLE},
   volume = {15},
   year = {2024}
}

TY  - JOUR
ID  - 2374257
AU  - Juříková, Lenka - Masárová, Lucia - Panovský, Roman - Pešl, Martin - Žondra Revendová, Kamila - Volný, Ondřej - Feitová, Věra - Holeček, Tomáš - Kincl, Vladimír - Danhofer, Pavlína - Voháňka, Stanislav - Haberlová, Jana - Karolína, Podolská
PY  - 2024
TI  - Decreased quality of life in Duchenne muscular disease patients related to functional neurological and cardiac impairment
JF  - Frontiers in Neurology
VL  - 15
IS  - February 2024
SP  - 1-11
EP  - 1-11
PB  - FRONTIERS MEDIA SA
SN  - 16642295
KW  - quality of life
KW  - Duchenne muscular dystrophy
KW  - cardiac magnetic resonance
KW  - neurological status
KW  - cardiac impairment
UR  - https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1360385/full?utm_source=F-NTF&utm_medium=EMLX&utm_campaign=PRD_FEOPS_20170000_ARTICLE
N2  - In this prospective study involving 37 Duchenne muscular dystrophy (DMD) patients aged 8–18 years and older, we examined the impact of neurological and cardiac factors on quality of life (QoL). Our findings revealed a negative correlation between upper limb movement and overall mobility, self-service, and usual activities. Ambulatory and non-ambulatory DMD patients showed significant differences in mobility-related parameters. Cardiac evaluations demonstrated associations between mitral annular plane systolic excursion (MAPSE) and mobility-related aspects. The PEDSQL 3.0 neuromuscular model questionnaire further highlighted age-related and movement-related correlations with QoL. The loss of ambulatory status and reduced upper limb movement were negatively associated with QoL, while upper limb movement positively correlated with septal MAPSE. However, no significant associations were found between MAPSE and anxiety/depression. These findings underscore the multifaceted impact of DMD on QoL and emphasize the importance of considering both neurological and cardiac factors in comprehensive patient care.
ER  -

JUŘÍKOVÁ, Lenka, Lucia MASÁROVÁ, Roman PANOVSKÝ, Martin PEŠL, Kamila ŽONDRA REVENDOVÁ, Ondřej VOLNÝ, Věra FEITOVÁ, Tomáš HOLEČEK, Vladimír KINCL, Pavlína DANHOFER, Stanislav VOHÁŇKA, Jana HABERLOVÁ and Podolská KAROLÍNA. Decreased quality of life in Duchenne muscular disease patients related to functional neurological and cardiac impairment. \textit{Frontiers in Neurology}. LAUSANNE: FRONTIERS MEDIA SA, 2024, vol.~15, February 2024, p.~1-11. ISSN~1664-2295. Available from: https://dx.doi.org/10.3389/fneur.2024.1360385.

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