Molecular Characterization and Phylogenetic Analysis of
Hepatitis E Virus (HEV) Strains from Pigs Farmed in Eight
European Countries between 2020 and 2022

J 2023

Molecular Characterization and Phylogenetic Analysis of Hepatitis E Virus (HEV) Strains from Pigs Farmed in Eight European Countries between 2020 and 2022

LUCA, De Sabato, Giovanni IANIRO, Giovanni L ALBORALI, Annelies KRONEMAN, Sylvia S GRIERSON et. al.

Basic information

Original name

Molecular Characterization and Phylogenetic Analysis of Hepatitis E Virus (HEV) Strains from Pigs Farmed in Eight European Countries between 2020 and 2022

Authors

LUCA, De Sabato, Giovanni IANIRO, Giovanni L ALBORALI, Annelies KRONEMAN, Sylvia S GRIERSON, Gergana Lyubomirova KRUMOVA-VALCHEVA, der Honing Renate W HAKZE-VAN, Reimar JOHNE, Ivana KOLÁČKOVÁ (203 Czech Republic, belonging to the institution), Iwona KOZYRA, Eva GYUROVA, Enrico PAVONI, Katharina REISP, Elena Lucia SASSU, Katja SCHILLING-LOEFFLER, Richard Piers SMITH, Petra VASICKOVA, Jacek ZMUDZKI, Artur RZEZUTKA and Di Bartolo ILARIA

Edition

Transboundary and Emerging Diseases, Hoboken, Wiley-Blackwell, 2023, 1865-1674

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30303 Infectious Diseases

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.300 in 2022

RIV identification code

RIV/00216224:14110/23:00133539

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1155/2023/2806835

UT WoS

001129293100001

Keywords in English

Hepatitis E Virus

Abstract

V originále

In high-income countries, the hepatitis E virus (HEV) is considered an emerging threat causing autochthonous acute hepatitis in humans, with an increased number of reported cases over the last 10 years and related increased burden of chronic hepatitis in immunocompromised and transplant patients. Pigs are the main reservoir of the HEV-3 genotype, which is the most common in Europe, and can be transmitted to humans through the consumption of raw and undercooked pork products. Extensive sequencing revealed the existence of several HEV-3 subtypes in both humans and pigs, confirming a broad heterogeneity of the virus, with some subtypes, such as 3e, 3f, and 3c, which are predominant in Europe. In this study, 291 HEV sequences were obtained from pig feces sampled in more than 74 farms located in Austria, Bulgaria, Czech Republic, Germany, Italy, Poland, the United Kingdom, as well as an unknown number of farms in Netherlands. Of the 99 nonidentical sequences (99/291), 90 were assigned to seven established HEV-3 subtypes: 3a, 3c, 3e, 3f, 3g (here named 3g-like), 3i, and 3l (named 3l-like), already described in Europe, while nine sequences of HEV-3 could not be assigned to any existing subtype (here named 3 *). The 3e subtype was the most common, detected in six out of eight countries, followed by 3f and 3c, which were also present in several countries; 3g-like, 3i, and 3l-like subtypes showed only a limited circulation. The distribution of frequently (3e, 3f, and 3c) and rarely (3g-like, 3i, and 3l-like) detected HEV-3 subtypes in pigs was correlated with their detection rates in human patients in Europe. The results from this study confirm the wide circulation of several HEV-3 strains in European pigs and confirm that sequencing is needed to monitor the different strains and to identify possible zoonotic transmission paths.

Citovat

LUCA, De Sabato, Giovanni IANIRO, Giovanni L ALBORALI, Annelies KRONEMAN, Sylvia S GRIERSON, Gergana Lyubomirova KRUMOVA-VALCHEVA, der Honing Renate W HAKZE-VAN, Reimar JOHNE, Ivana KOLÁČKOVÁ, Iwona KOZYRA, Eva GYUROVA, Enrico PAVONI, Katharina REISP, Elena Lucia SASSU, Katja SCHILLING-LOEFFLER, Richard Piers SMITH, Petra VASICKOVA, Jacek ZMUDZKI, Artur RZEZUTKA and Di Bartolo ILARIA. Molecular Characterization and Phylogenetic Analysis of Hepatitis E Virus (HEV) Strains from Pigs Farmed in Eight European Countries between 2020 and 2022. Transboundary and Emerging Diseases. Hoboken: Wiley-Blackwell, 2023, vol. 2023, December 2023, p. 1-12. ISSN 1865-1674. Available from: https://dx.doi.org/10.1155/2023/2806835.

@article{2374284,
   author = {Luca, De Sabato and Ianiro, Giovanni and Alborali, Giovanni L and Kroneman, Annelies and Grierson, Sylvia S and KrumovaandValcheva, Gergana Lyubomirova and Hakzeandvan, der Honing Renate W and Johne, Reimar and Koláčková, Ivana and Kozyra, Iwona and Gyurova, Eva and Pavoni, Enrico and Reisp, Katharina and Sassu, Elena Lucia and SchillingandLoeffler, Katja and Smith, Richard Piers and Vasickova, Petra and Zmudzki, Jacek and Rzezutka, Artur and Ilaria, Di Bartolo},
   article_location = {Hoboken},
   article_number = {December 2023},
   doi = {http://dx.doi.org/10.1155/2023/2806835},
   keywords = {Hepatitis E Virus},
   language = {eng},
   issn = {1865-1674},
   journal = {Transboundary and Emerging Diseases},
   title = {Molecular Characterization and Phylogenetic Analysis of Hepatitis E Virus (HEV) Strains from Pigs Farmed in Eight European Countries between 2020 and 2022},
   url = {https://www.hindawi.com/journals/tbed/2023/2806835/},
   volume = {2023},
   year = {2023}
}

TY  - JOUR
ID  - 2374284
AU  - Luca, De Sabato - Ianiro, Giovanni - Alborali, Giovanni L - Kroneman, Annelies - Grierson, Sylvia S - Krumova-Valcheva, Gergana Lyubomirova - Hakze-van, der Honing Renate W - Johne, Reimar - Koláčková, Ivana - Kozyra, Iwona - Gyurova, Eva - Pavoni, Enrico - Reisp, Katharina - Sassu, Elena Lucia - Schilling-Loeffler, Katja - Smith, Richard Piers - Vasickova, Petra - Zmudzki, Jacek - Rzezutka, Artur - Ilaria, Di Bartolo
PY  - 2023
TI  - Molecular Characterization and Phylogenetic Analysis of Hepatitis E Virus (HEV) Strains from Pigs Farmed in Eight European Countries between 2020 and 2022
JF  - Transboundary and Emerging Diseases
VL  - 2023
IS  - December 2023
SP  - 1-12
EP  - 1-12
PB  - Wiley-Blackwell
SN  - 18651674
KW  - Hepatitis E Virus
UR  - https://www.hindawi.com/journals/tbed/2023/2806835/
N2  - In high-income countries, the hepatitis E virus (HEV) is considered an emerging threat causing autochthonous acute hepatitis in humans, with an increased number of reported cases over the last 10 years and related increased burden of chronic hepatitis in immunocompromised and transplant patients. Pigs are the main reservoir of the HEV-3 genotype, which is the most common in Europe, and can be transmitted to humans through the consumption of raw and undercooked pork products. Extensive sequencing revealed the existence of several HEV-3 subtypes in both humans and pigs, confirming a broad heterogeneity of the virus, with some subtypes, such as 3e, 3f, and 3c, which are predominant in Europe. In this study, 291 HEV sequences were obtained from pig feces sampled in more than 74 farms located in Austria, Bulgaria, Czech Republic, Germany, Italy, Poland, the United Kingdom, as well as an unknown number of farms in Netherlands. Of the 99 nonidentical sequences (99/291), 90 were assigned to seven established HEV-3 subtypes: 3a, 3c, 3e, 3f, 3g (here named 3g-like), 3i, and 3l (named 3l-like), already described in Europe, while nine sequences of HEV-3 could not be assigned to any existing subtype (here named 3 *). The 3e subtype was the most common, detected in six out of eight countries, followed by 3f and 3c, which were also present in several countries; 3g-like, 3i, and 3l-like subtypes showed only a limited circulation. The distribution of frequently (3e, 3f, and 3c) and rarely (3g-like, 3i, and 3l-like) detected HEV-3 subtypes in pigs was correlated with their detection rates in human patients in Europe. The results from this study confirm the wide circulation of several HEV-3 strains in European pigs and confirm that sequencing is needed to monitor the different strains and to identify possible zoonotic transmission paths.
ER  -

LUCA, De Sabato, Giovanni IANIRO, Giovanni L ALBORALI, Annelies KRONEMAN, Sylvia S GRIERSON, Gergana Lyubomirova KRUMOVA-VALCHEVA, der Honing Renate W HAKZE-VAN, Reimar JOHNE, Ivana KOLÁČKOVÁ, Iwona KOZYRA, Eva GYUROVA, Enrico PAVONI, Katharina REISP, Elena Lucia SASSU, Katja SCHILLING-LOEFFLER, Richard Piers SMITH, Petra VASICKOVA, Jacek ZMUDZKI, Artur RZEZUTKA and Di Bartolo ILARIA. Molecular Characterization and Phylogenetic Analysis of Hepatitis E Virus (HEV) Strains from Pigs Farmed in Eight European Countries between 2020 and 2022. \textit{Transboundary and Emerging Diseases}. Hoboken: Wiley-Blackwell, 2023, vol.~2023, December 2023, p.~1-12. ISSN~1865-1674. Available from: https://dx.doi.org/10.1155/2023/2806835.

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