Songbirds avoid the oxidative stress costs of high blood
glucose levels: a comparative study

J 2024

Songbirds avoid the oxidative stress costs of high blood glucose levels: a comparative study

VÁGÁSI, Csongor I., Orsolya VINCZE, Marie KOTASOVÁ ADÁMKOVÁ, Tereza KAUZÁLOVÁ, Ádám Z. LENDVAI et. al.

Basic information

Original name

Songbirds avoid the oxidative stress costs of high blood glucose levels: a comparative study

Authors

VÁGÁSI, Csongor I., Orsolya VINCZE, Marie KOTASOVÁ ADÁMKOVÁ (203 Czech Republic, belonging to the institution), Tereza KAUZÁLOVÁ (203 Czech Republic), Ádám Z. LENDVAI, Laura I. PATRAS, Janka PÉNZES, Péter L. PAP, Tomáš ALBRECHT (203 Czech Republic) and Oldřich TOMÁŠEK (203 Czech Republic, belonging to the institution)

Edition

The Journal of Experimental Biology, Company of Biologists Ltd, 2024, 0022-0949

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10615 Ornithology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL URL

Impact factor

Impact factor: 2.800 in 2022

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1242/jeb.246848

UT WoS

001214515700010

Keywords in English

Antioxidants; Glucose; Hyperglycaemia; Lipid peroxidation; Phylogenetic comparison; Physiological ecology

Abstract

V originále

Chronically high blood glucose levels (hyperglycaemia) can compromise healthy ageing and lifespan at the individual level. Elevated oxidative stress can play a central role in hyperglycaemia-induced pathologies. Nevertheless, the lifespan of birds shows no species-level association with blood glucose. This suggests that the potential pathologies of high blood glucose levels can be avoided by adaptations in oxidative physiology at the macroevolutionary scale. However, this hypothesis remains unexplored. Here, we examined this hypothesis using comparative analyses controlled for phylogeny, allometry and fecundity based on data from 51 songbird species (681 individuals with blood glucose data and 1021 individuals with oxidative state data). We measured blood glucose at baseline and after stress stimulus and computed glucose stress reactivity as the magnitude of change between the two time points. We also measured three parameters of non-enzymatic antioxidants (uric acid, total antioxidants and glutathione) and a marker of oxidative lipid damage (malondialdehyde). We found no clear evidence for blood glucose concentration being correlated with either antioxidant or lipid damage levels at the macroevolutionary scale, as opposed to the hypothesis postulating that high blood glucose levels entail oxidative costs. The only exception was the moderate evidence for species with a stronger stress-induced increase in blood glucose concentration evolving moderately lower investment into antioxidant defence (uric acid and glutathione). Neither baseline nor stress-induced glucose levels were associated with oxidative physiology. Our findings support the hypothesis that birds evolved adaptations preventing the (glyc)oxidative costs of high blood glucose observed at the within-species level. Such adaptations may explain the decoupled evolution of glycaemia and lifespan in birds and possibly the paradoxical combination of long lifespan and high blood glucose levels relative to mammals.

Links

GA21-22160S, research and development project

Name: Diverzita a fyziologické mechanizmy stárnutí v populaci volně žijícího pěvce

Investor: Czech Science Foundation

Citovat

VÁGÁSI, Csongor I., Orsolya VINCZE, Marie KOTASOVÁ ADÁMKOVÁ, Tereza KAUZÁLOVÁ, Ádám Z. LENDVAI, Laura I. PATRAS, Janka PÉNZES, Péter L. PAP, Tomáš ALBRECHT and Oldřich TOMÁŠEK. Songbirds avoid the oxidative stress costs of high blood glucose levels: a comparative study. The Journal of Experimental Biology. Company of Biologists Ltd, 2024, vol. 227, No 1, p. jeb246848, 8 pp. ISSN 0022-0949. Available from: https://dx.doi.org/10.1242/jeb.246848.

@article{2374390,
   author = {Vágási, Csongor I. and Vincze, Orsolya and Kotasová Adámková, Marie and Kauzálová, Tereza and Lendvai, Ádám Z. and Patras, Laura I. and Pénzes, Janka and Pap, Péter L. and Albrecht, Tomáš and Tomášek, Oldřich},
   article_number = {1},
   doi = {http://dx.doi.org/10.1242/jeb.246848},
   keywords = {Antioxidants; Glucose; Hyperglycaemia; Lipid peroxidation; Phylogenetic comparison; Physiological ecology},
   language = {eng},
   issn = {0022-0949},
   journal = {The Journal of Experimental Biology},
   title = {Songbirds avoid the oxidative stress costs of high blood glucose levels: a comparative study},
   url = {https://journals.biologists.com/jeb/article-abstract/227/1/jeb246848/340680/Songbirds-avoid-the-oxidative-stress-costs-of-high?redirectedFrom=fulltext},
   volume = {227},
   year = {2024}
}

TY  - JOUR
ID  - 2374390
AU  - Vágási, Csongor I. - Vincze, Orsolya - Kotasová Adámková, Marie - Kauzálová, Tereza - Lendvai, Ádám Z. - Patras, Laura I. - Pénzes, Janka - Pap, Péter L. - Albrecht, Tomáš - Tomášek, Oldřich
PY  - 2024
TI  - Songbirds avoid the oxidative stress costs of high blood glucose levels: a comparative study
JF  - The Journal of Experimental Biology
VL  - 227
IS  - 1
SP  - jeb246848
EP  - jeb246848
PB  - Company of Biologists Ltd
SN  - 00220949
KW  - Antioxidants
KW  - Glucose
KW  - Hyperglycaemia
KW  - Lipid peroxidation
KW  - Phylogenetic comparison
KW  - Physiological ecology
UR  - https://journals.biologists.com/jeb/article-abstract/227/1/jeb246848/340680/Songbirds-avoid-the-oxidative-stress-costs-of-high?redirectedFrom=fulltext
N2  - Chronically high blood glucose levels (hyperglycaemia) can compromise healthy ageing and lifespan at the individual level. Elevated oxidative stress can play a central role in hyperglycaemia-induced pathologies. Nevertheless, the lifespan of birds shows no species-level association with blood glucose. This suggests that the potential pathologies of high blood glucose levels can be avoided by adaptations in oxidative physiology at the macroevolutionary scale. However, this hypothesis remains unexplored. Here, we examined this hypothesis using comparative analyses controlled for phylogeny, allometry and fecundity based on data from 51 songbird species (681 individuals with blood glucose data and 1021 individuals with oxidative state data). We measured blood glucose at baseline and after stress stimulus and computed glucose stress reactivity as the magnitude of change between the two time points. We also measured three parameters of non-enzymatic antioxidants (uric acid, total antioxidants and glutathione) and a marker of oxidative lipid damage (malondialdehyde). We found no clear evidence for blood glucose concentration being correlated with either antioxidant or lipid damage levels at the macroevolutionary scale, as opposed to the hypothesis postulating that high blood glucose levels entail oxidative costs. The only exception was the moderate evidence for species with a stronger stress-induced increase in blood glucose concentration evolving moderately lower investment into antioxidant defence (uric acid and glutathione). Neither baseline nor stress-induced glucose levels were associated with oxidative physiology. Our findings support the hypothesis that birds evolved adaptations preventing the (glyc)oxidative costs of high blood glucose observed at the within-species level. Such adaptations may explain the decoupled evolution of glycaemia and lifespan in birds and possibly the paradoxical combination of long lifespan and high blood glucose levels relative to mammals.
ER  -

VÁGÁSI, Csongor I., Orsolya VINCZE, Marie KOTASOVÁ ADÁMKOVÁ, Tereza KAUZÁLOVÁ, Ádám Z. LENDVAI, Laura I. PATRAS, Janka PÉNZES, Péter L. PAP, Tomáš ALBRECHT and Oldřich TOMÁŠEK. Songbirds avoid the oxidative stress costs of high blood glucose levels: a comparative study. \textit{The Journal of Experimental Biology}. Company of Biologists Ltd, 2024, vol.~227, No~1, p.~jeb246848, 8 pp. ISSN~0022-0949. Available from: https://dx.doi.org/10.1242/jeb.246848.

Detailed Information on Publication Record