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@article{2375338,
author = {RodriguezandGalan, Ana and Dosil, Sara G and Vlčková, Anna and FernandezandMessina, Lola and Feketová, Zuzana and Pokorná, Julie and FernandezandDelgado, Irene and Camafeita, Emilio and Gomez, Manuel Jose and RamirezandHuesca, Marta and GutierrezandVazquez, Cristina and SanchezandCabo, Fatima and Vazquez, Jesus and Vaňáčová, Štěpánka and SanchezandMadrid, Francisco},
article_location = {BASEL},
article_number = {9},
doi = {http://dx.doi.org/10.1007/s00018-023-04925-2},
keywords = {Exonuclease; T cell; Immunoregulatory},
language = {eng},
issn = {1420-682X},
journal = {Cellular and molecular life sciences},
title = {ISG20L2: an RNA nuclease regulating T cell activation},
url = {https://link.springer.com/article/10.1007/s00018-023-04925-2},
volume = {80},
year = {2023}
}
TY - JOUR
ID - 2375338
AU - Rodriguez-Galan, Ana - Dosil, Sara G - Vlčková, Anna - Fernandez-Messina, Lola - Feketová, Zuzana - Pokorná, Julie - Fernandez-Delgado, Irene - Camafeita, Emilio - Gomez, Manuel Jose - Ramirez-Huesca, Marta - Gutierrez-Vazquez, Cristina - Sanchez-Cabo, Fatima - Vazquez, Jesus - Vaňáčová, Štěpánka - Sanchez-Madrid, Francisco
PY - 2023
TI - ISG20L2: an RNA nuclease regulating T cell activation
JF - Cellular and molecular life sciences
VL - 80
IS - 9
SP - 1-19
EP - 1-19
PB - BIRKHAUSER VERLAG AG
SN - 1420682X
KW - Exonuclease
KW - T cell
KW - Immunoregulatory
UR - https://link.springer.com/article/10.1007/s00018-023-04925-2
N2 - ISG20L2, a 3' to 5' exoribonuclease previously associated with ribosome biogenesis, is identified here in activated T cells as an enzyme with a preferential affinity for uridylated miRNA substrates. This enzyme is upregulated in T lymphocytes upon TCR and IFN type I stimulation and appears to be involved in regulating T cell function. ISG20L2 silencing leads to an increased basal expression of CD69 and induces greater IL2 secretion. However, ISG20L2 absence impairs CD25 upregula-tion, CD3 synaptic accumulation and MTOC translocation towards the antigen-presenting cell during immune synapsis. Remarkably, ISG20L2 controls the expression of immunoregulatory molecules, such as AHR, NKG2D, CTLA-4, CD137, TIM-3, PD-L1 or PD-1, which show increased levels in ISG20L2 knockout T cells. The dysregulation observed in these key molecules for T cell responses support a role for this exonuclease as a novel RNA-based regulator of T cell function.
ER -
RODRIGUEZ-GALAN, Ana, Sara G DOSIL, Anna VLČKOVÁ, Lola FERNANDEZ-MESSINA, Zuzana FEKETOVÁ, Julie POKORNÁ, Irene FERNANDEZ-DELGADO, Emilio CAMAFEITA, Manuel Jose GOMEZ, Marta RAMIREZ-HUESCA, Cristina GUTIERREZ-VAZQUEZ, Fatima SANCHEZ-CABO, Jesus VAZQUEZ, Štěpánka VAŇÁČOVÁ and Francisco SANCHEZ-MADRID. ISG20L2: an RNA nuclease regulating T cell activation. \textit{Cellular and molecular life sciences}. BASEL: BIRKHAUSER VERLAG AG, 2023, vol.~80, No~9, p.~1-19. ISSN~1420-682X. Available from: https://dx.doi.org/10.1007/s00018-023-04925-2.
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