A preliminary choroid plexus volumetric study in individuals
with psychosis

J 2023

A preliminary choroid plexus volumetric study in individuals with psychosis

SENAY, Olcay, Magdalena SEETHALER, Nikos MAKRIS, Edward YETERIAN, Jarrett RUSHMORE et. al.

Basic information

Original name

A preliminary choroid plexus volumetric study in individuals with psychosis

Authors

SENAY, Olcay, Magdalena SEETHALER, Nikos MAKRIS, Edward YETERIAN, Jarrett RUSHMORE, Kang Ik K CHO, Elizabeth RIZZONI, Carina HELLER, Ofer PASTERNAK, Filip SZCZEPANKIEWICZ, Carl-Frederik WESTIN, Jan LOŠÁK (203 Czech Republic, belonging to the institution), Libor USTOHAL (203 Czech Republic, belonging to the institution), Josef TOMANDL (203 Czech Republic, belonging to the institution), Lubomír VOJTÍŠEK (203 Czech Republic, belonging to the institution), Petr KUDLIČKA (203 Czech Republic, belonging to the institution), Zora KIKINIS, Daphne HOLT, Kathryn E LEWANDOWSKI, Paulo LIZANO, Matcheri S KESHAVAN, Dost ONGUR, Tomáš KAŠPÁREK (203 Czech Republic, belonging to the institution), Alan BREIER, Martha E SHENTON, Johanna SEITZ-HOLLAND and Marek KUBICKI (guarantor)

Edition

Human Brain mapping, Hoboken, WILEY-BLACKWELL, 2023, 1065-9471

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.800 in 2022

RIV identification code

RIV/00216224:14110/23:00133568

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1002/hbm.26224

UT WoS

000928827400001

Keywords in English

cerebrospinal fluid; manual segmentation; neuroinflammation; perivascular space; schizophrenia; ventricle

Abstract

V originále

The choroid plexus (ChP) is part of the blood-cerebrospinal fluid barrier, regulating brain homeostasis and the brain's response to peripheral events. Its upregulation and enlargement are considered essential in psychosis. However, the timing of the ChP enlargement has not been established. This study introduces a novel magnetic resonance imaging-based segmentation method to examine ChP volumes in two cohorts of individuals with psychosis. The first sample consists of 41 individuals with early course psychosis (mean duration of illness = 1.78 years) and 30 healthy individuals. The second sample consists of 30 individuals with chronic psychosis (mean duration of illness = 7.96 years) and 34 healthy individuals. We utilized manual segmentation to measure ChP volumes. We applied ANCOVAs to compare normalized ChP volumes between groups and partial correlations to investigate the relationship between ChP, LV volumes, and clinical characteristics. Our segmentation demonstrated good reliability (.87). We further showed a significant ChP volume increase in early psychosis (left: p < .00010, right: p < .00010) and a significant positive correlation between higher ChP and higher LV volumes in chronic psychosis (left: r = .54, p = .0030, right: r = .68; p < .0010). Our study suggests that ChP enlargement may be a marker of acute response around disease onset. It might also play a modulatory role in the chronic enlargement of lateral ventricles, often reported in psychosis. Future longitudinal studies should investigate the dynamics of ChP enlargement as a promising marker for novel therapeutic strategies.

Links

90129, large research infrastructures

Name: Czech-BioImaging II

Citovat

SENAY, Olcay, Magdalena SEETHALER, Nikos MAKRIS, Edward YETERIAN, Jarrett RUSHMORE, Kang Ik K CHO, Elizabeth RIZZONI, Carina HELLER, Ofer PASTERNAK, Filip SZCZEPANKIEWICZ, Carl-Frederik WESTIN, Jan LOŠÁK, Libor USTOHAL, Josef TOMANDL, Lubomír VOJTÍŠEK, Petr KUDLIČKA, Zora KIKINIS, Daphne HOLT, Kathryn E LEWANDOWSKI, Paulo LIZANO, Matcheri S KESHAVAN, Dost ONGUR, Tomáš KAŠPÁREK, Alan BREIER, Martha E SHENTON, Johanna SEITZ-HOLLAND and Marek KUBICKI. A preliminary choroid plexus volumetric study in individuals with psychosis. Human Brain mapping. Hoboken: WILEY-BLACKWELL, 2023, vol. 44, No 6, p. 2465-2478. ISSN 1065-9471. Available from: https://dx.doi.org/10.1002/hbm.26224.

@article{2375397,
   author = {Senay, Olcay and Seethaler, Magdalena and Makris, Nikos and Yeterian, Edward and Rushmore, Jarrett and Cho, Kang Ik K and Rizzoni, Elizabeth and Heller, Carina and Pasternak, Ofer and Szczepankiewicz, Filip and Westin, CarlandFrederik and Lošák, Jan and Ustohal, Libor and Tomandl, Josef and Vojtíšek, Lubomír and Kudlička, Petr and Kikinis, Zora and Holt, Daphne and Lewandowski, Kathryn E and Lizano, Paulo and Keshavan, Matcheri S and Ongur, Dost and Kašpárek, Tomáš and Breier, Alan and Shenton, Martha E and SeitzandHolland, Johanna and Kubicki, Marek},
   article_location = {Hoboken},
   article_number = {6},
   doi = {http://dx.doi.org/10.1002/hbm.26224},
   keywords = {cerebrospinal fluid; manual segmentation; neuroinflammation; perivascular space; schizophrenia; ventricle},
   language = {eng},
   issn = {1065-9471},
   journal = {Human Brain mapping},
   title = {A preliminary choroid plexus volumetric study in individuals with psychosis},
   url = {https://onlinelibrary.wiley.com/doi/10.1002/hbm.26224},
   volume = {44},
   year = {2023}
}

TY  - JOUR
ID  - 2375397
AU  - Senay, Olcay - Seethaler, Magdalena - Makris, Nikos - Yeterian, Edward - Rushmore, Jarrett - Cho, Kang Ik K - Rizzoni, Elizabeth - Heller, Carina - Pasternak, Ofer - Szczepankiewicz, Filip - Westin, Carl-Frederik - Lošák, Jan - Ustohal, Libor - Tomandl, Josef - Vojtíšek, Lubomír - Kudlička, Petr - Kikinis, Zora - Holt, Daphne - Lewandowski, Kathryn E - Lizano, Paulo - Keshavan, Matcheri S - Ongur, Dost - Kašpárek, Tomáš - Breier, Alan - Shenton, Martha E - Seitz-Holland, Johanna - Kubicki, Marek
PY  - 2023
TI  - A preliminary choroid plexus volumetric study in individuals with psychosis
JF  - Human Brain mapping
VL  - 44
IS  - 6
SP  - 2465-2478
EP  - 2465-2478
PB  - WILEY-BLACKWELL
SN  - 10659471
KW  - cerebrospinal fluid
KW  - manual segmentation
KW  - neuroinflammation
KW  - perivascular space
KW  - schizophrenia
KW  - ventricle
UR  - https://onlinelibrary.wiley.com/doi/10.1002/hbm.26224
N2  - The choroid plexus (ChP) is part of the blood-cerebrospinal fluid barrier, regulating brain homeostasis and the brain's response to peripheral events. Its upregulation and enlargement are considered essential in psychosis. However, the timing of the ChP enlargement has not been established. This study introduces a novel magnetic resonance imaging-based segmentation method to examine ChP volumes in two cohorts of individuals with psychosis. The first sample consists of 41 individuals with early course psychosis (mean duration of illness = 1.78 years) and 30 healthy individuals. The second sample consists of 30 individuals with chronic psychosis (mean duration of illness = 7.96 years) and 34 healthy individuals. We utilized manual segmentation to measure ChP volumes. We applied ANCOVAs to compare normalized ChP volumes between groups and partial correlations to investigate the relationship between ChP, LV volumes, and clinical characteristics. Our segmentation demonstrated good reliability (.87). We further showed a significant ChP volume increase in early psychosis (left: p < .00010, right: p < .00010) and a significant positive correlation between higher ChP and higher LV volumes in chronic psychosis (left: r = .54, p = .0030, right: r = .68; p < .0010). Our study suggests that ChP enlargement may be a marker of acute response around disease onset. It might also play a modulatory role in the chronic enlargement of lateral ventricles, often reported in psychosis. Future longitudinal studies should investigate the dynamics of ChP enlargement as a promising marker for novel therapeutic strategies.
ER  -

SENAY, Olcay, Magdalena SEETHALER, Nikos MAKRIS, Edward YETERIAN, Jarrett RUSHMORE, Kang Ik K CHO, Elizabeth RIZZONI, Carina HELLER, Ofer PASTERNAK, Filip SZCZEPANKIEWICZ, Carl-Frederik WESTIN, Jan LOŠÁK, Libor USTOHAL, Josef TOMANDL, Lubomír VOJTÍŠEK, Petr KUDLIČKA, Zora KIKINIS, Daphne HOLT, Kathryn E LEWANDOWSKI, Paulo LIZANO, Matcheri S KESHAVAN, Dost ONGUR, Tomáš KAŠPÁREK, Alan BREIER, Martha E SHENTON, Johanna SEITZ-HOLLAND and Marek KUBICKI. A preliminary choroid plexus volumetric study in individuals with psychosis. \textit{Human Brain mapping}. Hoboken: WILEY-BLACKWELL, 2023, vol.~44, No~6, p.~2465-2478. ISSN~1065-9471. Available from: https://dx.doi.org/10.1002/hbm.26224.

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