Detailed Information on Publication Record
2023
Ketamine disrupts locomotion and electrolocation in a novel model of schizophrenia, Gnathonemus petersii fish
LANGOVA, Veronika, Petra HORKA, Jan HUBENY, Tomas NOVAK, Karel VALES et. al.Basic information
Original name
Ketamine disrupts locomotion and electrolocation in a novel model of schizophrenia, Gnathonemus petersii fish
Authors
LANGOVA, Veronika, Petra HORKA, Jan HUBENY, Tomas NOVAK, Karel VALES, Petr ADAMEK, Katerina HOLUBOVA and Jiri HORACEK
Edition
Journal of Neuroscience Research, HOBOKEN, WILEY, 2023, 0360-4012
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30230 Other clinical medicine subjects
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 4.200 in 2022
RIV identification code
RIV/00216224:90249/23:00133574
UT WoS
000943024600001
Keywords (in Czech)
electrolocation; Gnathonemus petersii; positive symptoms; schizophrenia model; weakly electric fish
Keywords in English
electrolocation; Gnathonemus petersii; positive symptoms; schizophrenia model; weakly electric fish
Tags
Tags
International impact, Reviewed
Změněno: 12/4/2024 13:04, Mgr. Michal Petr
Abstract
V originále
The present study aimed to examine a weakly electric fish Gnathonemus petersii (G. petersii) as a candidate model organism of glutamatergic theory of schizophrenia. The idea of G. petersii elevating the modeling of schizophrenia symptoms is based on the fish's electrolocation and electrocommunication abilities. Fish were exposed to the NMDA antagonist ketamine in two distinct series differing in the dose of ketamine. The main finding revealed ketamine-induced disruption of the relationship between electric signaling and behavior indicating impairment of fish navigation. Moreover, lower doses of ketamine significantly increased locomotion and erratic movement and higher doses of ketamine reduced the number of electric organ discharges indicating successful induction of positive schizophrenia-like symptoms and disruption of fish navigation. Additionally, a low dose of haloperidol was used to test the normalization of the positive symptoms to suggest a predictive validity of the model. However, although successfully induced, positive symptoms were not normalized using the low dose of haloperidol; hence, more doses of the typical antipsychotic haloperidol and probably also of a representative of atypical antipsychotic drugs need to be examined to confirm the predictive validity of the model.
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