J 2023

Ketamine disrupts locomotion and electrolocation in a novel model of schizophrenia, Gnathonemus petersii fish

LANGOVA, Veronika, Petra HORKA, Jan HUBENY, Tomas NOVAK, Karel VALES et. al.

Basic information

Original name

Ketamine disrupts locomotion and electrolocation in a novel model of schizophrenia, Gnathonemus petersii fish

Authors

LANGOVA, Veronika, Petra HORKA, Jan HUBENY, Tomas NOVAK, Karel VALES, Petr ADAMEK, Katerina HOLUBOVA and Jiri HORACEK

Edition

Journal of Neuroscience Research, HOBOKEN, WILEY, 2023, 0360-4012

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30230 Other clinical medicine subjects

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 4.200 in 2022

RIV identification code

RIV/00216224:90249/23:00133574

UT WoS

000943024600001

Keywords (in Czech)

electrolocation; Gnathonemus petersii; positive symptoms; schizophrenia model; weakly electric fish

Keywords in English

electrolocation; Gnathonemus petersii; positive symptoms; schizophrenia model; weakly electric fish

Tags

International impact, Reviewed
Změněno: 12/4/2024 13:04, Mgr. Michal Petr

Abstract

V originále

The present study aimed to examine a weakly electric fish Gnathonemus petersii (G. petersii) as a candidate model organism of glutamatergic theory of schizophrenia. The idea of G. petersii elevating the modeling of schizophrenia symptoms is based on the fish's electrolocation and electrocommunication abilities. Fish were exposed to the NMDA antagonist ketamine in two distinct series differing in the dose of ketamine. The main finding revealed ketamine-induced disruption of the relationship between electric signaling and behavior indicating impairment of fish navigation. Moreover, lower doses of ketamine significantly increased locomotion and erratic movement and higher doses of ketamine reduced the number of electric organ discharges indicating successful induction of positive schizophrenia-like symptoms and disruption of fish navigation. Additionally, a low dose of haloperidol was used to test the normalization of the positive symptoms to suggest a predictive validity of the model. However, although successfully induced, positive symptoms were not normalized using the low dose of haloperidol; hence, more doses of the typical antipsychotic haloperidol and probably also of a representative of atypical antipsychotic drugs need to be examined to confirm the predictive validity of the model.

Links

90249, large research infrastructures
Name: CZECRIN IV