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@article{2375897,
author = {Weiss, Viktor and Kokošová, Viktória and Valenta, Zdenek and Doležalová, Irena and Baláž, Marek and Mangia, Silvia and Michaeli, Shalom and Vojtíšek, Lubomír and Nestrasil, Igor and Herzig, Roman and Filip, Pavel},
article_location = {San Diego},
article_number = {January 2024},
doi = {http://dx.doi.org/10.1016/j.neuroimage.2023.120502},
keywords = {Quantitative MRI; Relaxometry; Diffusion weighted imaging; Resting -state functional MRI; Arterial distance},
language = {eng},
issn = {1053-8119},
journal = {Neuroimage},
title = {Distance from main arteries influences microstructural and functional brain tissue characteristics},
url = {https://www.sciencedirect.com/science/article/pii/S1053811923006523?via%3Dihub},
volume = {285},
year = {2024}
}
TY - JOUR
ID - 2375897
AU - Weiss, Viktor - Kokošová, Viktória - Valenta, Zdenek - Doležalová, Irena - Baláž, Marek - Mangia, Silvia - Michaeli, Shalom - Vojtíšek, Lubomír - Nestrasil, Igor - Herzig, Roman - Filip, Pavel
PY - 2024
TI - Distance from main arteries influences microstructural and functional brain tissue characteristics
JF - Neuroimage
VL - 285
IS - January 2024
SP - 1-7
EP - 1-7
PB - ACADEMIC PRESS INC ELSEVIER SCIENCE
SN - 10538119
KW - Quantitative MRI
KW - Relaxometry
KW - Diffusion weighted imaging
KW - Resting -state functional MRI
KW - Arterial distance
UR - https://www.sciencedirect.com/science/article/pii/S1053811923006523?via%3Dihub
N2 - Given the substantial dependence of neurons on continuous supply of energy, the distribution of major cerebral arteries opens a question whether the distance from the main supply arteries constitutes a modulating factor for the microstructural and functional properties of brain tissue. To tackle this question, multimodal MRI acquisitions of 102 healthy volunteers over the full adult age span were utilised. Relaxation along a fictitious field in the rotating frame of rank n = 4 (RAFF4), adiabatic T1p, T2p, and intracellular volume fraction (fICVF) derived from diffusion-weighted imaging were implemented to quantify microstructural (cellularity, myelin density, iron concentration) tissue characteristics and degree centrality and fractional amplitude of low-frequency fluctuations to probe for functional metrics. Inverse correlation of arterial distance with robust homogeneity was detected for T1p, T2p and RAFF4 for cortical grey matter and white matter, showing substantial complex microstructural differences between brain tissue close and farther from main arterial trunks. Albeit with wider variability, functional metrics pointed to increased connectivity and neuronal activity in areas farther from main arteries. Surprisingly, multiple of these microstructural and functional distance-based gradients diminished with higher age, pointing to uniformization of brain tissue with ageing. All in all, this pilot study provides a novel insight on brain regionalisation based on artery distance, which merits further investigation to validate its biological underpinnings.
ER -
WEISS, Viktor, Viktória KOKOŠOVÁ, Zdenek VALENTA, Irena DOLEŽALOVÁ, Marek BALÁŽ, Silvia MANGIA, Shalom MICHAELI, Lubomír VOJTÍŠEK, Igor NESTRASIL, Roman HERZIG and Pavel FILIP. Distance from main arteries influences microstructural and functional brain tissue characteristics. \textit{Neuroimage}. San Diego: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2024, vol.~285, January 2024, p.~1-7. ISSN~1053-8119. Available from: https://dx.doi.org/10.1016/j.neuroimage.2023.120502.
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