WEISS, Viktor, Viktória KOKOŠOVÁ, Zdenek VALENTA, Irena DOLEŽALOVÁ, Marek BALÁŽ, Silvia MANGIA, Shalom MICHAELI, Lubomír VOJTÍŠEK, Igor NESTRASIL, Roman HERZIG and Pavel FILIP. Distance from main arteries influences microstructural and functional brain tissue characteristics. Neuroimage. San Diego: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2024, vol. 285, January 2024, p. 1-7. ISSN 1053-8119. Available from: https://dx.doi.org/10.1016/j.neuroimage.2023.120502.
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Basic information
Original name Distance from main arteries influences microstructural and functional brain tissue characteristics
Authors WEISS, Viktor (203 Czech Republic, belonging to the institution), Viktória KOKOŠOVÁ (703 Slovakia, belonging to the institution), Zdenek VALENTA (203 Czech Republic), Irena DOLEŽALOVÁ (203 Czech Republic, belonging to the institution), Marek BALÁŽ (703 Slovakia, belonging to the institution), Silvia MANGIA, Shalom MICHAELI, Lubomír VOJTÍŠEK (203 Czech Republic, belonging to the institution), Igor NESTRASIL (203 Czech Republic), Roman HERZIG (203 Czech Republic) and Pavel FILIP (703 Slovakia, guarantor).
Edition Neuroimage, San Diego, ACADEMIC PRESS INC ELSEVIER SCIENCE, 2024, 1053-8119.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30210 Clinical neurology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 5.700 in 2022
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1016/j.neuroimage.2023.120502
UT WoS 001139614000001
Keywords in English Quantitative MRI; Relaxometry; Diffusion weighted imaging; Resting -state functional MRI; Arterial distance
Tags 14110127, 14110221, CF MAFIL, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Eva Dubská, učo 77638. Changed: 9/3/2024 14:52.
Abstract
Given the substantial dependence of neurons on continuous supply of energy, the distribution of major cerebral arteries opens a question whether the distance from the main supply arteries constitutes a modulating factor for the microstructural and functional properties of brain tissue. To tackle this question, multimodal MRI acquisitions of 102 healthy volunteers over the full adult age span were utilised. Relaxation along a fictitious field in the rotating frame of rank n = 4 (RAFF4), adiabatic T1p, T2p, and intracellular volume fraction (fICVF) derived from diffusion-weighted imaging were implemented to quantify microstructural (cellularity, myelin density, iron concentration) tissue characteristics and degree centrality and fractional amplitude of low-frequency fluctuations to probe for functional metrics. Inverse correlation of arterial distance with robust homogeneity was detected for T1p, T2p and RAFF4 for cortical grey matter and white matter, showing substantial complex microstructural differences between brain tissue close and farther from main arterial trunks. Albeit with wider variability, functional metrics pointed to increased connectivity and neuronal activity in areas farther from main arteries. Surprisingly, multiple of these microstructural and functional distance-based gradients diminished with higher age, pointing to uniformization of brain tissue with ageing. All in all, this pilot study provides a novel insight on brain regionalisation based on artery distance, which merits further investigation to validate its biological underpinnings.
Links
LM2018129, research and development projectName: Národní infrastruktura pro biologické a medicínské zobrazování Czech-BioImaging
Investor: Ministry of Education, Youth and Sports of the CR
PrintDisplayed: 15/6/2024 19:02