Distance from main arteries influences microstructural and
functional brain tissue characteristics

J 2024

Distance from main arteries influences microstructural and functional brain tissue characteristics

WEISS, Viktor, Viktória KOKOŠOVÁ, Zdenek VALENTA, Irena DOLEŽALOVÁ, Marek BALÁŽ et. al.

Basic information

Original name

Distance from main arteries influences microstructural and functional brain tissue characteristics

Authors

WEISS, Viktor (203 Czech Republic, belonging to the institution), Viktória KOKOŠOVÁ (703 Slovakia, belonging to the institution), Zdenek VALENTA (203 Czech Republic), Irena DOLEŽALOVÁ (203 Czech Republic, belonging to the institution), Marek BALÁŽ (703 Slovakia, belonging to the institution), Silvia MANGIA, Shalom MICHAELI, Lubomír VOJTÍŠEK (203 Czech Republic, belonging to the institution), Igor NESTRASIL (203 Czech Republic), Roman HERZIG (203 Czech Republic) and Pavel FILIP (703 Slovakia, guarantor)

Edition

Neuroimage, San Diego, ACADEMIC PRESS INC ELSEVIER SCIENCE, 2024, 1053-8119

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.700 in 2022

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.neuroimage.2023.120502

UT WoS

001139614000001

Keywords in English

Quantitative MRI; Relaxometry; Diffusion weighted imaging; Resting -state functional MRI; Arterial distance

Abstract

V originále

Given the substantial dependence of neurons on continuous supply of energy, the distribution of major cerebral arteries opens a question whether the distance from the main supply arteries constitutes a modulating factor for the microstructural and functional properties of brain tissue. To tackle this question, multimodal MRI acquisitions of 102 healthy volunteers over the full adult age span were utilised. Relaxation along a fictitious field in the rotating frame of rank n = 4 (RAFF4), adiabatic T1p, T2p, and intracellular volume fraction (fICVF) derived from diffusion-weighted imaging were implemented to quantify microstructural (cellularity, myelin density, iron concentration) tissue characteristics and degree centrality and fractional amplitude of low-frequency fluctuations to probe for functional metrics. Inverse correlation of arterial distance with robust homogeneity was detected for T1p, T2p and RAFF4 for cortical grey matter and white matter, showing substantial complex microstructural differences between brain tissue close and farther from main arterial trunks. Albeit with wider variability, functional metrics pointed to increased connectivity and neuronal activity in areas farther from main arteries. Surprisingly, multiple of these microstructural and functional distance-based gradients diminished with higher age, pointing to uniformization of brain tissue with ageing. All in all, this pilot study provides a novel insight on brain regionalisation based on artery distance, which merits further investigation to validate its biological underpinnings.

Links

LM2018129, research and development project

Name: Národní infrastruktura pro biologické a medicínské zobrazování Czech-BioImaging

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

WEISS, Viktor, Viktória KOKOŠOVÁ, Zdenek VALENTA, Irena DOLEŽALOVÁ, Marek BALÁŽ, Silvia MANGIA, Shalom MICHAELI, Lubomír VOJTÍŠEK, Igor NESTRASIL, Roman HERZIG and Pavel FILIP. Distance from main arteries influences microstructural and functional brain tissue characteristics. Neuroimage. San Diego: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2024, vol. 285, January 2024, p. 1-7. ISSN 1053-8119. Available from: https://dx.doi.org/10.1016/j.neuroimage.2023.120502.

@article{2375897,
   author = {Weiss, Viktor and Kokošová, Viktória and Valenta, Zdenek and Doležalová, Irena and Baláž, Marek and Mangia, Silvia and Michaeli, Shalom and Vojtíšek, Lubomír and Nestrasil, Igor and Herzig, Roman and Filip, Pavel},
   article_location = {San Diego},
   article_number = {January 2024},
   doi = {http://dx.doi.org/10.1016/j.neuroimage.2023.120502},
   keywords = {Quantitative MRI; Relaxometry; Diffusion weighted imaging; Resting -state functional MRI; Arterial distance},
   language = {eng},
   issn = {1053-8119},
   journal = {Neuroimage},
   title = {Distance from main arteries influences microstructural and functional brain tissue characteristics},
   url = {https://www.sciencedirect.com/science/article/pii/S1053811923006523?via%3Dihub},
   volume = {285},
   year = {2024}
}

TY  - JOUR
ID  - 2375897
AU  - Weiss, Viktor - Kokošová, Viktória - Valenta, Zdenek - Doležalová, Irena - Baláž, Marek - Mangia, Silvia - Michaeli, Shalom - Vojtíšek, Lubomír - Nestrasil, Igor - Herzig, Roman - Filip, Pavel
PY  - 2024
TI  - Distance from main arteries influences microstructural and functional brain tissue characteristics
JF  - Neuroimage
VL  - 285
IS  - January 2024
SP  - 1-7
EP  - 1-7
PB  - ACADEMIC PRESS INC ELSEVIER SCIENCE
SN  - 10538119
KW  - Quantitative MRI
KW  - Relaxometry
KW  - Diffusion weighted imaging
KW  - Resting -state functional MRI
KW  - Arterial distance
UR  - https://www.sciencedirect.com/science/article/pii/S1053811923006523?via%3Dihub
N2  - Given the substantial dependence of neurons on continuous supply of energy, the distribution of major cerebral arteries opens a question whether the distance from the main supply arteries constitutes a modulating factor for the microstructural and functional properties of brain tissue. To tackle this question, multimodal MRI acquisitions of 102 healthy volunteers over the full adult age span were utilised. Relaxation along a fictitious field in the rotating frame of rank n = 4 (RAFF4), adiabatic T1p, T2p, and intracellular volume fraction (fICVF) derived from diffusion-weighted imaging were implemented to quantify microstructural (cellularity, myelin density, iron concentration) tissue characteristics and degree centrality and fractional amplitude of low-frequency fluctuations to probe for functional metrics. Inverse correlation of arterial distance with robust homogeneity was detected for T1p, T2p and RAFF4 for cortical grey matter and white matter, showing substantial complex microstructural differences between brain tissue close and farther from main arterial trunks. Albeit with wider variability, functional metrics pointed to increased connectivity and neuronal activity in areas farther from main arteries. Surprisingly, multiple of these microstructural and functional distance-based gradients diminished with higher age, pointing to uniformization of brain tissue with ageing. All in all, this pilot study provides a novel insight on brain regionalisation based on artery distance, which merits further investigation to validate its biological underpinnings.
ER  -

WEISS, Viktor, Viktória KOKOŠOVÁ, Zdenek VALENTA, Irena DOLEŽALOVÁ, Marek BALÁŽ, Silvia MANGIA, Shalom MICHAELI, Lubomír VOJTÍŠEK, Igor NESTRASIL, Roman HERZIG and Pavel FILIP. Distance from main arteries influences microstructural and functional brain tissue characteristics. \textit{Neuroimage}. San Diego: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2024, vol.~285, January 2024, p.~1-7. ISSN~1053-8119. Available from: https://dx.doi.org/10.1016/j.neuroimage.2023.120502.

Detailed Information on Publication Record